Knowledge Translation for Patients With Acute Coronary Syndromes

NCT02672137 | Completed

• 1 other identifier: DIREG_L_04201
• Study Type: interventional
• Target: 4,604
• Locations: 0 countries
• Sites: N/A

Brief Summary

Cluster randomized open-label experimental study multi-center of 24 hospitals to either knowledge translation vs usual care to improve care of patents hospitalized for acute coronary syndromes.

Conditions

Acute Coronary Syndromes

Keywords

myocardial infarction; knowledge transfer; acute coronary syndromes

Outcome Measures

Primary Outcomes (1)

• Proportion of patients who received evidence-based medical therapy at hospital discharge (mean of 4 days)

  Evidence-based medical therapy is defined as aspirin,dual-antiplaquelets, beta-blockers, statins.

  at hospital discharge (average of 4 days)

Secondary Outcomes (2)

• Discharge prescription of individual evidence-based medical therapy: aspirin, dual antiplatelets, beta-blockers

  at hospital discharge (average of 4 days)

• Safety endpoints (mortality, reinfarction, strokes and bleeding outcomes (TIMI major and minor bleeds))

  in-hospital (average of 4 days)

Study Arms (2)

knowledge translation

EXPERIMENTAL

knowledge translation 12-month multi-facet intensive knowledge translation measures that include: Community of practice, local gap analysis, opinion leaders, targeted interventions, performance feedback, reminders and local formation of ACS teams.

Behavioral: knowledge translation

Usual care

NO INTERVENTION

no intervention

Interventions

knowledge translation BEHAVIORAL

knowledge translation that include: Community of practice, local gap analysis, opinion leaders, targeted interventions, performance feedback, reminders and local formation of ACS teams.

knowledge translation

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Myocardial infarction with ST-segment elevation
• Myocardial infarction without ST-segment elevation
• Unstable angina
• Acute coronary syndromes -

You may not qualify if:

• Non-atherosclerotic coronary artery disease (as confirmed by coronary angiograms or other non-invasive tests such as stress test, coronary CT-scan, nuclear scans)
• Hospital stay of less than 48 hours -

Sponsors & Collaborators

• Montreal General Hospital: lead
• Sanofi: collaborator
• Canadian Institutes of Health Research (CIHR): collaborator
• Fonds de la Recherche en Santé du Québec: collaborator

Related Publications (1)

• Huynh T, Kouz S, Afilalo M, Rinfret S, Schampaert E, Mansour S, Montigny M, Eisenberg MJ, Lauzon C, Dery JP, Nguyen M, L'Allier P, Harvey R, Boudreault C, Tardif JC. Knowledge Translation to improve prescription of evidence-based medical therapy for patients admitted with acute coronary syndromes: insights from the AMI-OPTIMA study. Journal of the American College of Cardiology.J Am Coll Cardiol. 2015;65(10_S).

  RESULT

MeSH Terms

Conditions

Acute Coronary Syndrome; Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• thao huynh, md,msc,phd

  Montreal General Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Cardiologist, associate professor of medicine

Study Record Dates

• First Submitted: January 10, 2016
• First Posted: February 3, 2016
• Study Start: January 1, 2010
• Primary Completion: December 1, 2015
• Study Completion: January 1, 2016
• Last Updated: February 3, 2016

Record last verified: 2016-01

Data Sharing

• IPD Sharing: Will not share