Two Cycling Off Modes in Pressure Support: Study of Respiratory Mechanics, Breathing Comfort and Asynchrony Patterns

NCT00910286 | Completed

• 1 other identifier: Two cycling off modes in psv
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: To compare termination criteria (TC) of pressure support ventilation (PSV). Design: Randomized cross-over clinical trial. Setting: Intensive Care Units. Patients: Sixteen patients on PSV with ability to answer a visual analog scale (VAS). Protocol and Measurements: Each patient was ventilated with two different TC ventilators, fixed and automatic, with measurements of ventilatory mechanic variables, breathing comfort and asynchrony patterns.

Conditions

Ventilator Weaning; Respiration, Artificial

Keywords

Pressure support ventilation; cycling off criteria; expiratory trigger; patient-ventilator interaction; patient comfort

Outcome Measures

Primary Outcomes (1)

• comfort

  30 minutes

Study Arms (1)

VENTILATOR WEANING

OTHER

Two ventilators with different flow termination criteria (TC) were compared: Servo 300 (Siemens-Elema, Sweden) with fixed TC (5% of peak inspiratory flow) and Newport E500 (Newport Medical Instruments, CA) with automatic TC (varies between 5% to 55%). Each patient remained three hours in the protocol, one hour in each ventilator, after been randomized to one of two sequences of 3 steps: Fixed 5% / Automatic / Fixed 5% or Automatic / Fixed 5% / Automatic . The PS, the positive end expiratory pressure (PEEP), the inspiratory oxygen fraction (FiO2) and the pressure trigger sensitivity levels were unchanged during the protocol.

Other: Pulmonary Ventilator

Interventions

Pulmonary Ventilator OTHER

The aim of the present study was to compare two different cycling off modes in PSV, a fixed and other automatic, about ventilatory mechanic variables, breathing comfort and patient-ventilator asynchrony patterns

Also known as: pressure support

VENTILATOR WEANING

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients under PSV for more than 24 hours,
• Age \> 18 years
• Ability to answer to a symptom visual analog scale (VAS)

You may not qualify if:

• Hemodynamic instability (use of vasoactive drugs like dopamine, dobutamine or norepinephrine)
• Bronchopleural fistula

Sponsors & Collaborators

• Hospital de Clinicas de Porto Alegre: lead

Study Sites (1)

Hospital Mae de Deus

Porto Alegre, Rio Grande do Sul, 91900580, Brazil

Location

Related Publications (2)

• Du HL, Yamada Y. Expiratory asynchrony. Respir Care Clin N Am. 2005 Jun;11(2):265-80. doi: 10.1016/j.rcc.2005.02.001.

  PMID: 15936693 BACKGROUND

• Hoff FC, Tucci MR, Amato MB, Santos LJ, Victorino JA. Cycling-off modes during pressure support ventilation: effects on breathing pattern, patient effort, and comfort. J Crit Care. 2014 Jun;29(3):380-5. doi: 10.1016/j.jcrc.2014.01.015. Epub 2014 Jan 29.

  PMID: 24612764 DERIVED

MeSH Terms

Conditions

Respiratory Aspiration

Interventions

Ventilators, Mechanical

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Equipment and Supplies

Study Officials

• josue a victorino, phd

  Hospital de Clinicas de Porto Alegre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 28, 2009
• First Posted: May 29, 2009
• Study Start: December 1, 2004
• Primary Completion: December 1, 2007
• Study Completion: June 1, 2008
• Last Updated: May 29, 2009

Record last verified: 2009-05

Locations

BR (1)