Clinical, Histological and Biochemical Characterization of Hyperpigmented Lesion
2 other identifiers
observational
160
1 country
1
Brief Summary
Hypothesis - The developments of solar lentigine and melasma are due to mutations in keratinocytes that drive the production and transfer of pigment from melanocytes to keratinocytes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jun 2008
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2008
CompletedFirst Submitted
Initial submission to the registry
June 2, 2010
CompletedFirst Posted
Study publicly available on registry
June 3, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2015
CompletedJanuary 28, 2014
January 1, 2014
6.9 years
June 2, 2010
January 26, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Characterization and classification of lentigines and melasma
Characterize and classify lentigines and mealsma from a clinical and physiological point of view. This will better understand the cellular processes leading to the development of lentigines (also referred to as Senile or Solar Lentigo). Proper characterization and classification of lentigines and melasma would facilitate the development of models to study and find solutions to treat these lesions.
3 years
Study Arms (1)
Subjects with hyper-pigmented spots
Subjects age 21 to 80 year old, who have elected to undergo a plastic surgery will be enrolled. Subjects will be from Chinese, Malay, Indian or Caucasian ancestry. Subjects will be female or male with a hyper-pigmented spots.
Eligibility Criteria
Subjects age 21 to 80 year old, who have elected to undergo a plastic surgery will be enrolled. Patients will be from Chinese, Malay, Indian or Caucasian ancestry. Patients will be female or male with hyper-pigmented spots.
You may qualify if:
- Solar Lentigines and/or Melasma on facial, or neck areas
- Ethnic background: Chinese, Malay, Indian, Caucasian
- Age 21 - 80 years old
- Ability to provide informed consent
You may not qualify if:
- Pregnant and lactating women
- Children under the age of 20
- Neoplasm (past or present) in excised area
- Patients with communicable disease
- Immuno-compromised patients
- Current treatment with an investigational drug
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National University Hospital, Singapore
Singapore, Singapore, 119074, Singapore
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Thiam Chye Lim, MD
National University Hospital, Singapore
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
June 2, 2010
First Posted
June 3, 2010
Study Start
June 1, 2008
Primary Completion
May 1, 2015
Study Completion
May 1, 2015
Last Updated
January 28, 2014
Record last verified: 2014-01