NCT01134809|CompletedDMC
Skeletal Muscle Wasting and Insulin Resistance Following Surgical Stress
SIRSS
Does Surgical Stress Impair Skeletal Muscle Protein and Carbohydrate Metabolism?
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SIRSS
Does Surgical Stress Impair Skeletal Muscle Protein and Carbohydrate Metabolism?
Sponsor study identifier
observational
15
1 country
1
Study Start
May 2010
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
May 2013
Actual (reported)Study Completion
May 2013
Actual (reported)Background: Skeletal muscle wasting or decrease in muscle mass occurs as a result of alteration in the body's mechanisms to make or break muscle protein. In animal models, the pathway termed as 'ubiquitin-proteasome pathway' (UPP) is primarily responsible for the regulation of skeletal muscle protein loss in wasting conditions and during infection(sepsis). Skeletal muscle wasting is noticed in patients having major surgery due to the inflammatory reaction triggered by special group of proteins called cytokines (inflammatory proteins), resulting in reduced muscle strength, impaired capacity to fight infections, change in bowel function, increased clinical complications and prolonged recovery. Major surgery also leads to decreased sensitivity to hormone known as insulin, resulting in 'diabeteslike'state. We hypothesize that susceptibility of patients undergoing major abdominal surgery, to skeletal muscle wasting and insulin resistance, is determined by stress response to surgery over time, leading to changes in the pathways that make or break muscle protein, namely the Akt/Foxo signalling and UPP. Therefore, the aim of this study is to establish the underlying mechanisms of skeletal muscle wasting and insulin resistance in patients undergoing major abdominal surgery.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 2013
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 2010
Date type not reportedThis date has not been verified as actual or estimated.
May 28, 2010
Actual (reported)June 2, 2010
Actual (reported)May 2013
Actual (reported)May 2013
Actual (reported)postoperative insulin resistance
First week following surgery
Patients having major abdominal surgery
All adult patients having major abdominal surgery
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
All adult patients having major abdominal surgery
University Hospitals Nottingham Queen's Medical Centre
Nottingham, Nottingham, NG7 2UH, United Kingdom
Atkins R, Constantin-Teodosiu D, Varadhan KK, Constantin D, Lobo DN, Greenhaff PL. Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function. Clin Nutr. 2021 Mar;40(3):1046-1051. doi: 10.1016/j.clnu.2020.07.006. Epub 2020 Jul 14.
Varadhan KK, Constantin-Teodosiu D, Constantin D, Greenhaff PL, Lobo DN. Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery. Clin Nutr. 2018 Dec;37(6 Pt A):2178-2185. doi: 10.1016/j.clnu.2017.10.020. Epub 2017 Nov 2.
Dileep N Lobo, Professor
University of Notitngham
15 participants (actual enrollment reported by the registry).
First Submitted
May 28, 2010
First Posted
June 2, 2010
Study Start
May 2010
Date type not reportedThis date has not been verified as actual or estimated.
Skeletal Muscle Protein Metabolism and Insulin Sensitivity in Overweight Individuals: Effects of Meals With Various Fatty Acid Compositions
Contact the study team to confirm eligibility.
Primary Completion
May 2013
Actual (reported)Study Completion
May 2013
Actual (reported)Last Updated
June 9, 2015
Record last verified: 2015-06
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Source: ClinicalTrials.gov.
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