NCT01229059|Completed
Free Fatty Acid Induced Insulin Resistance
FFAIR
Assessment of the Time Course of Lipid Induced Insulin Resistance
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FFAIR
Assessment of the Time Course of Lipid Induced Insulin Resistance
Sponsor study identifier
observational
55
1 country
1
Study Start
March 2010
Actual (reported)Primary Completion
November 2019
Actual (reported)Study Completion
November 2019
Actual (reported)This study aims to explore time-dependent effects of lipid infusion an intramyocellular lipid metabolites and the induction of impaired insulin signaling.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 2019
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2010
Actual (reported)March 20, 2010
Actual (reported)October 27, 2010
Actual (reported)November 2019
Actual (reported)November 2019
Actual (reported)intramyocellular lipid metabolites
Muscle biopsies are taken before, after 2.5 and 4 hours of lipid infusion
after 4 hours lipid infusion
muscle glucose flux
glycogen synthesis rate, glucose-6-phosphate
during lipid infusion
insulin resistance of glucose uptake and mitochondrial function
after 4 hours lipid infusion
healthy lean humans before and after lipid infusion
endurance trained atheletes
Lipid enriched infusions will be applied for 2-6 hours.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Healthy, lean non-diabetic humans
German Diabetes Center
Düsseldorf, North Rhine-Westphalia, 40225, Germany
Phielix E, Begovatz P, Gancheva S, Bierwagen A, Kornips E, Schaart G, Hesselink MKC, Schrauwen P, Roden M. Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion. JCI Insight. 2019 Nov 1;4(21):e127928. doi: 10.1172/jci.insight.127928.
Fritsch M, Koliaki C, Livingstone R, Phielix E, Bierwagen A, Meisinger M, Jelenik T, Strassburger K, Zimmermann S, Brockmann K, Wolff C, Hwang JH, Szendroedi J, Roden M. Time course of postprandial hepatic phosphorus metabolites in lean, obese, and type 2 diabetes patients. Am J Clin Nutr. 2015 Nov;102(5):1051-8. doi: 10.3945/ajcn.115.107599. Epub 2015 Sep 30.
muscle biopsies
Michael Roden, Prof., MD
German Diabetes Center
55 participants (actual enrollment reported by the registry).
First Submitted
March 20, 2010
First Posted
October 27, 2010
Study Start
March 2010
Actual (reported)Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.
Contact the study team to confirm eligibility.
Primary Completion
November 2019
Actual (reported)Study Completion
November 2019
Actual (reported)Last Updated
August 15, 2023
Record last verified: 2023-08
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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