NCT01116609

Brief Summary

The purpose of this study is to define the local metabolic effects of epinephrine in the bilaterally perfused human leg.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for not_applicable healthy

Timeline
Completed

Started Oct 2004

Longer than P75 for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2004

Completed
5.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2009

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2010

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

April 9, 2010

Completed
26 days until next milestone

First Posted

Study publicly available on registry

May 5, 2010

Completed
Last Updated

November 7, 2011

Status Verified

November 1, 2011

Enrollment Period

5.1 years

First QC Date

April 9, 2010

Last Update Submit

November 4, 2011

Conditions

Healthy

Keywords

PhenylalaninePalmitatehyperinsulinemic-euglycemic-clampEffects of epinephrine in healthy volunteers

Outcome Measures

Primary Outcomes (1)

  • Arterio-Venous balances of metabolites

    Acute regional effect of epinephrine infusion in the femoral artery

    6 hours infusion

Interventions

EpinephrineDRUG

unilateral leg infusion of Epinephrine 0.4 micrograms/m2/min

Also known as: Adrenaline

Eligibility Criteria

Age18 Years - 50 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Male

You may not qualify if:

  • Comorbidity
  • Females

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Medical research laboratories, Aarhus University Hospital

Aarhus, 8000, Denmark

Location

MeSH Terms

Interventions

Epinephrine

Intervention Hierarchy (Ancestors)

EthanolaminesAmino AlcoholsAlcoholsOrganic ChemicalsAminesBiogenic MonoaminesBiogenic AminesCatecholaminesCatecholsPhenolsBenzene DerivativesHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbons

Study Officials

  • Niels Moller, Professor

    Medical Research Laboratories, Aarhus University, Denmark

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 9, 2010

First Posted

May 5, 2010

Study Start

October 1, 2004

Primary Completion

November 1, 2009

Study Completion

January 1, 2010

Last Updated

November 7, 2011

Record last verified: 2011-11

Locations

DK(1)