Effects of Stevia on Satiety and Eating Attitudes in Healthy, Overweight and Obese Adults

NCT01115088 | Completed

• 1 other identifier: PBRC 25030
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to test the effects that three different types of sweeteners have on food intake, hunger and satiety levels, as well as insulin and glucose measures. The study of whether food or beverages containing Stevia influence food intake to a greater extent than food or beverages sweetened with Aspartame or Sucrose. Also, examining whether taste preference and taste sensitivity influence food intake.

Conditions

Obesity; Type 2 Diabetes

Outcome Measures

Primary Outcomes (1)

• Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels.

  Test whether preloads of tea and crackers with cream cheese sweetened with Stevia lover postprandial insulin levels compared to preloads of tea and crackers with cream cheese sweetened with Sucrose or Aspartame by measuring blood insulin and glucose levels immediately prior to the lunch preload,immediately before lunch test meal, and at thirty minutes, one hour, and two hours after the lunch test meal.

  24 hours

Secondary Outcomes (2)

• Hedonic ratings (appearance, aroma, flavor, texture and palatability)with Stevia sweetener compared to Sucrose or Aspartame

  24 hours

• Satiating effects by examining food consumption

  24 Hours

Study Arms (3)

Aspartame

EXPERIMENTAL

Food or beverages containing Aspartame in comparison to Stevia or Sucrose

Dietary Supplement: Aspartame

Sucrose

EXPERIMENTAL

Food or beverages containing Sucrose in comparison to Aspartame or Stevia

Dietary Supplement: Sucrose

Stevia

EXPERIMENTAL

Food or beverages containing Stevia in comparison to Aspartame or Sucrose

Dietary Supplement: Stevia

Interventions

Aspartame DIETARY_SUPPLEMENT

The morning breakfast after a 12-h fast and consumed a standard 469 kcal breakfast consisting of cereal, milk, toast with butter, and orange juice. Tea and crackers with cream cheese sweetened with stevia Whole Foods 365 Brand, aspartame equal sweetener, or sucrose participants consumed this preload 20 min before their test lunch and dinner meals. The Test lunch meal consisted of sandwiches, potato chips, and cookies, and the test dinner meal was a self-selected buffet-type meal (I.e., Macronutrient Self-Selection Paradigm) Geiselman et al,. 1998)

Also known as: equal sweetener

Aspartame

Sucrose DIETARY_SUPPLEMENT

The morning breakfast after a 12-h fast and consumed a standard 469 kcal breakfast consisting of cereal, milk, toast with butter, and orange juice. Tea and crackers with cream cheese sweetened with stevia Whole Foods 365 Brand, aspartame equal sweetener, or sucrose participants consumed this preload 20 min before their test lunch and dinner meals. The Test lunch meal consisted of sandwiches, potato chips, and cookies, and the test dinner meal was a self-selected buffet-type meal (I.e., Macronutrient Self-Selection Paradigm) Geiselman et al,. 1998)

Sucrose

Stevia DIETARY_SUPPLEMENT

The morning breakfast after a 12-h fast and consumed a standard 469 kcal breakfast consisting of cereal, milk, toast with butter, and orange juice. Tea and crackers with cream cheese sweetened with stevia Whole Foods 365 Brand, aspartame equal sweetener, or sucrose participants consumed this preload 20 min before their test lunch and dinner meals. The Test lunch meal consisted of sandwiches, potato chips, and cookies, and the test dinner meal was a self-selected buffet-type meal (I.e., Macronutrient Self-Selection Paradigm) Geiselman et al,. 1998)

Stevia

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy and have a body mass index \> 30 kg/m2 and \< 39.9 kg/m2, or have a body mass index \> 20 kg/m2 and \< 24.9 kg/m2
• If BMI is between 30 and 39.9, waist circumference must be \> 36 for women and \> 40 for men.
• Age 18 to 45 years
• Nonsmokers
• Willing to consume meat products
• Women on monophasic oral contraceptives or who have physiologically controlled cycles

You may not qualify if:

• A history of diabetes, cardiovascular disease, or other chronic illnesses
• Presence of an eating disorder including Anorexia and/or Bulimia Nervosa
• Other health problems that might interfere with your ability to participate in the study
• Taking medications, other than monophasic birth control or monophasic (same dose every day) hormone replacement therapy and allergy medication
• Taking allergy medication for a period of time less than 6 months
• Dislike of or allergy to foods/sweeteners (Sucrose, Stevia, or Aspartame) used in test meals
• Smokers
• High scores on the Dietary Restraint, Disinhibition, and Perceived Hunger scales of the Three Factor Eating Questionnaire
• Use of oral contraceptives other than monophasic (same dose every day) contraceptives

Sponsors & Collaborators

• Pennington Biomedical Research Center: lead

Study Sites (1)

Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States

Location

MeSH Terms

Conditions

Obesity; Diabetes Mellitus, Type 2

Interventions

Aspartame; Sucrose; stevioside

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Dipeptides; Oligopeptides; Peptides; Amino Acids, Peptides, and Proteins; Disaccharides; Oligosaccharides; Polysaccharides; Carbohydrates; Sugars

Study Officials

• Stephen D. Anton, PhD

  Pennington Biomedical Research Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Executive Director

Study Record Dates

• First Submitted: April 29, 2010
• First Posted: May 4, 2010
• Study Start: January 1, 2006
• Primary Completion: April 1, 2010
• Study Completion: April 1, 2010
• Last Updated: February 12, 2016

Record last verified: 2016-02

Locations

US (1)