LOC387715/HTRA1 Variants in Polypoidal Choroidal Vasculopathy in a Korean Population
PCV
1 other identifier
interventional
215
1 country
1
Brief Summary
This study is to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy and whether they are associated with clinical patterns including angiographic phenotype in a Korean population.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Apr 2010
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2010
CompletedFirst Submitted
Initial submission to the registry
April 19, 2010
CompletedFirst Posted
Study publicly available on registry
April 21, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2011
CompletedAugust 30, 2011
August 1, 2011
4 months
April 19, 2010
August 28, 2011
Conditions
Outcome Measures
Primary Outcomes (1)
Genotyping of LOC387715/HTRA1 of PCV and control groups
to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy (PCV)
4weeks
Secondary Outcomes (2)
Indocyanine angiographic findings of polypoidal choroidal vasculopathy
20 minutes
Visual acuity using Snellen chart
2 x 5 minutes
Study Arms (2)
polypoidal choroidal vasculopathy
EXPERIMENTALpatients with polypoidal choroidal vasculopathy
control
ACTIVE COMPARATORcontrol group with no polypoidal choroidal vasculopathy
Interventions
Genomic DNA was extracted from whole blood by standard methods. Genotyping was performed using SNP Genotyping Assays.
Eligibility Criteria
You may qualify if:
- patients older than 60 years of age at onset
- polyp-like terminal aneurysmal dilations with or without branching vascular networks in indocyanine green angiography and subretinal reddish-orange protrusions corresponding to polyp-like lesions
You may not qualify if:
- eyes with pathologic myopia, angioid streaks, central serous chorioretinopathy, and other retinal or choroidal diseases
- Control group
- individuals without retinal diseases and without any signs of polypoidal choroidal vasculopathy or age-related macular degeneration on the bases of comprehensive ophthalmic examination results
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
In Taek Kim
Daegu, Kyungsangpookdo, 700-721, South Korea
Related Publications (1)
Gotoh N, Nakanishi H, Hayashi H, Yamada R, Otani A, Tsujikawa A, Yamashiro K, Tamura H, Saito M, Saito K, Iida T, Matsuda F, Yoshimura N. ARMS2 (LOC387715) variants in Japanese patients with exudative age-related macular degeneration and polypoidal choroidal vasculopathy. Am J Ophthalmol. 2009 Jun;147(6):1037-41, 1041.e1-2. doi: 10.1016/j.ajo.2008.12.036. Epub 2009 Mar 9.
PMID: 19268887BACKGROUND
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
In Taek Kim, M.D.
Kyungpook National University Hospital
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- clinical professor
Study Record Dates
First Submitted
April 19, 2010
First Posted
April 21, 2010
Study Start
April 1, 2010
Primary Completion
August 1, 2010
Study Completion
August 1, 2011
Last Updated
August 30, 2011
Record last verified: 2011-08