The Role of Influenza as a Trigger for Acute Myocardial Infarction: a CALIBER Study

NCT01106196 | Completed DMC

• 3 other identifiers: CALIBER 09-08Ref G0800689, no. 87420Ref 086091/Z/08/Z
• Study Type: observational
• Target: 11,208
• Locations: 1 country
• Sites: 2

Brief Summary

The purpose of this study is to examine the incidence of acute myocardial infarction (MI) occurring after an influenza-like illness using linked primary care and disease registry databases.

Conditions

Myocardial Infarction; Influenza

Keywords

Influenza, Human; Influenza, Human/complications; Myocardial infarction/etiology; Cardiovascular Diseases/mortality

Outcome Measures

Primary Outcomes (1)

• Incidence ratio for acute MI

  Incidence ratio for MI occurring in time periods after presentation to primary care with an acute respiratory illness compared to baseline time periods

  28 days

Study Arms (1)

MI plus respiratory illness

Patients with an incident myocardial infarction who also have a record of a visit to primary care with a respiratory tract infection

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with an incident myocardial infarction who also have a record of a visit to primary care with a respiratory tract infection occurring within the study period (01/01/99 - 31/12/2008)

You may qualify if:

• Participants must be registered with a GPRD 'up to standard' practice during the study period 01/01/1999-31/12/2008
• They must have a record of an incident myocardial infarction (defined by a Read codelist submitted to and agreed by GPRD) that occurs both within their registration and the study period
• They must have at least 6 months between their registration date and the date of the incident MI
• They must have accessed primary care on at least one occasion for a respiratory illness during the study period

You may not qualify if:

• Not fulfilling above criteria

Sponsors & Collaborators

• University College, London: lead
• London School of Hygiene and Tropical Medicine: collaborator
• Open University: collaborator

Study Sites (2)

University College London (UCL)

London, London, NW3 2PF, United Kingdom

Location

London School of Hygiene & Tropical Medicine

London, London, WC1E 7HT, United Kingdom

Location

Related Publications (1)

• Warren-Gash C, Hayward AC, Hemingway H, Denaxas S, Thomas SL, Timmis AD, Whitaker H, Smeeth L. Influenza infection and risk of acute myocardial infarction in England and Wales: a CALIBER self-controlled case series study. J Infect Dis. 2012 Dec 1;206(11):1652-9. doi: 10.1093/infdis/jis597. Epub 2012 Oct 9.

  PMID: 23048170 DERIVED

MeSH Terms

Conditions

Myocardial Infarction; Influenza, Human; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Respiratory Tract Infections; Infections; Orthomyxoviridae Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases

Study Officials

• Harry Hemingway, FRCP

  UCL

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: April 16, 2010
• First Posted: April 19, 2010
• Study Start: April 1, 2010
• Primary Completion: October 1, 2012
• Study Completion: October 1, 2012
• Last Updated: December 2, 2014

Record last verified: 2014-12

Locations

GB (2)