NCT00965354

Brief Summary

The ultimate goal of this collaborative, intensive study is to discover new and effective treatments and to develop better vaccines that can be used in future outbreaks of Influenza A. By integrating the information that we will gather, we will create a unique overview of how influenza causes illness and what might be done to improve patient management.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
131

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Dec 2009

Geographic Reach
1 country

8 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 24, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

August 25, 2009

Completed
3 months until next milestone

Study Start

First participant enrolled

December 1, 2009

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2011

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2011

Completed
13.6 years until next milestone

Results Posted

Study results publicly available

September 19, 2024

Completed
Last Updated

September 19, 2024

Status Verified

April 1, 2024

Enrollment Period

1.2 years

First QC Date

August 24, 2009

Results QC Date

October 25, 2023

Last Update Submit

April 16, 2024

Conditions

Influenza

Keywords

severeacuteinfluenzaconsortiumswinefluinfluenza AH1N1hospitaladmission

Outcome Measures

Primary Outcomes (1)

  • Number of Patients With Clinical Phenotype Presenting Also a Sequential Activation of Immune/Infammatory Pathways.

    Detailed clinical phenotype. Clinicopathological correlation will then be sought between the clinical phenotype and pathological parameters measured as per work packages.

    15 months

Study Arms (1)

Influenza diagnosis

Patients admitted to hospital with a suspected or confirmed influenza diagnosis on admission

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Hospital admissions

You may qualify if:

  • Any patient admitted to hospital with suspected or confirmed influenza infection

You may not qualify if:

  • Patients who do not give their consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (8)

Alder Hey Children's Foundation NHS Trust

Liverpool, L12 2AP, United Kingdom

Location

Royal Liverpool University Hospital

Liverpool, L7 8XP, United Kingdom

Location

Liverpool Women's NHS Foundation Trust

Liverpool, L8 7SS, United Kingdom

Location

Aintree Hospitals NHS Trust

Liverpool, L9 7AL, United Kingdom

Location

Chelsea and Westminster Hospital NHS Foundation Trust

London, SW10 9NH, United Kingdom

Location

Royal Brompton and Harefield NHS Foundation Trust

London, SW3 6NP, United Kingdom

Location

Imperial College Healthcare NHS Trust

London, W2 1PG, United Kingdom

Location

Wirral University Teaching Hospital NHS Foundation Trust

Metropolitan Borough of Wirral, CH49 5PE, United Kingdom

Location

Related Publications (2)

  • Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJM; MOSAIC Investigators. Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nat Immunol. 2018 Jun;19(6):625-635. doi: 10.1038/s41590-018-0111-5. Epub 2018 May 18.

    PMID: 29777224RESULT

  • Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ; MOSAIC Investigators; Moffatt MF, O'Garra A, Openshaw PJM. Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nat Immunol. 2019 Mar;20(3):373. doi: 10.1038/s41590-019-0328-y.

    PMID: 30728492RESULT

Biospecimen

Retention: SAMPLES WITH DNA

A) Swabs and secretions from the nose and throat B) Blood C) Sputum D) Urine E) Stool In addition, if the patients are having further respiratory sample collection as part of their routine care, for example tracheal aspirates, bronchial lavage and other samples then we would like to take an additional amount of these samples for our research.

MeSH Terms

Conditions

Influenza, HumanLymphoma, Follicular

Condition Hierarchy (Ancestors)

Respiratory Tract InfectionsInfectionsOrthomyxoviridae InfectionsRNA Virus InfectionsVirus DiseasesRespiratory Tract DiseasesLymphoma, Non-HodgkinLymphomaNeoplasms by Histologic TypeNeoplasmsLymphoproliferative DisordersLymphatic DiseasesHemic and Lymphatic DiseasesImmunoproliferative DisordersImmune System Diseases

Results Point of Contact

Title
Openshaw, Peter J M
Organization
Imperial College
p.openshaw@imperial.ac.uk
07973 820 801

Study Officials

  • Peter JM Openshaw

    Imperial College London

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 24, 2009

First Posted

August 25, 2009

Study Start

December 1, 2009

Primary Completion

February 1, 2011

Study Completion

February 1, 2011

Last Updated

September 19, 2024

Results First Posted

September 19, 2024

Record last verified: 2024-04

Data Sharing

IPD Sharing
Will not share

Locations

GB(8)