NCT01099241

Brief Summary

Ultrasound may be useful for noninvasively determining the central venous pressure. We intend to compare the clinical examination of the neck veins; ultrasound delineation of the internal jugular vein; and the central venous pressure measured with an intravascular catheter.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
38

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Aug 2007

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2007

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2010

Completed
25 days until next milestone

First Submitted

Initial submission to the registry

March 26, 2010

Completed
11 days until next milestone

First Posted

Study publicly available on registry

April 6, 2010

Completed
Last Updated

April 6, 2010

Status Verified

March 1, 2010

Enrollment Period

2.6 years

First QC Date

March 26, 2010

Last Update Submit

April 5, 2010

Conditions

Central Venous Pressure

Keywords

CVPUSUltrasonography

Outcome Measures

Primary Outcomes (1)

  • Correlation of CVP measurement via ultrasound and central venous catheter

    CVP as determined non-invasively with the transcutaneous ultrasound probe will correlate with a high degree of accuracy to the measurement obtained invasively by the catheter and pressure transducer.

    At data collection: this is a physiologic study

Secondary Outcomes (1)

  • Correlation of CVP measurement via physical examination of IJV and EJV.

    At data collection: physiologic study

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients admitted to Intensive care unit.

You may qualify if:

  • adult medical or surgical ICU patients who have preexisting central venous (jugular/subclavian only) catheters.

You may not qualify if:

  • subjects with only a femoral venous catheter.
  • subjects whose CVP measurement by the indwelling catheter exceeds 20cm of water.
  • subjects younger than 18 years old.
  • inability to obtain informed consent from the subject or the subjects authorized representative.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Iowa

Iowa City, Iowa, 52246, United States

Location

Related Publications (9)

  • Baumann UA, Marquis C, Stoupis C, Willenberg TA, Takala J, Jakob SM. Estimation of central venous pressure by ultrasound. Resuscitation. 2005 Feb;64(2):193-9. doi: 10.1016/j.resuscitation.2004.08.015.

    PMID: 15680529BACKGROUND

  • Bazaral M, Harlan S. Ultrasonographic anatomy of the internal jugular vein relevant to percutaneous cannulation. Crit Care Med. 1981 Apr;9(4):307-10. doi: 10.1097/00003246-198104000-00004.

    PMID: 7214938BACKGROUND

  • Cook DJ. Clinical assessment of central venous pressure in the critically ill. Am J Med Sci. 1990 Mar;299(3):175-8. doi: 10.1097/00000441-199003000-00006.

    PMID: 2316561BACKGROUND

  • Davison R, Cannon R. Estimation of central venous pressure by examination of jugular veins. Am Heart J. 1974 Mar;87(3):279-82. doi: 10.1016/0002-8703(74)90064-7. No abstract available.

    PMID: 4812363BACKGROUND

  • Lipton B. Estimation of central venous pressure by ultrasound of the internal jugular vein. Am J Emerg Med. 2000 Jul;18(4):432-4. doi: 10.1053/ajem.2000.7335.

    PMID: 10919533BACKGROUND

  • Lipton BM. Determination of elevated jugular venous pressure by real-time ultrasound. Ann Emerg Med. 1999 Jul;34(1):115. doi: 10.1016/s0196-0644(99)70287-8. No abstract available.

    PMID: 10409088BACKGROUND

  • Rizvi K, Deboisblanc BP, Truwit JD, Dhillon G, Arroliga A, Fuchs BD, Guntupalli KK, Hite D, Hayden D; NIH/NHLBI ARDS Clinical Trials Network. Effect of airway pressure display on interobserver agreement in the assessment of vascular pressures in patients with acute lung injury and acute respiratory distress syndrome. Crit Care Med. 2005 Jan;33(1):98-103; discussion 243-4. doi: 10.1097/01.ccm.0000150650.70142.e9.

    PMID: 15644654BACKGROUND

  • Vinayak AG, Levitt J, Gehlbach B, Pohlman AS, Hall JB, Kress JP. Usefulness of the external jugular vein examination in detecting abnormal central venous pressure in critically ill patients. Arch Intern Med. 2006 Oct 23;166(19):2132-7. doi: 10.1001/archinte.166.19.2132.

    PMID: 17060544BACKGROUND

  • Deol GR, Collett N, Ashby A, Schmidt GA. Ultrasound accurately reflects the jugular venous examination but underestimates central venous pressure. Chest. 2011 Jan;139(1):95-100. doi: 10.1378/chest.10-1301. Epub 2010 Aug 26.

    PMID: 20798190DERIVED

Study Officials

  • Gregory A Schmidt

    Roy J. & Lucille A. Carver College of Medicine, University of Iowa

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

March 26, 2010

First Posted

April 6, 2010

Study Start

August 1, 2007

Primary Completion

March 1, 2010

Study Completion

March 1, 2010

Last Updated

April 6, 2010

Record last verified: 2010-03

Locations

US(1)