Effects Of Unilateral Vibration On Contralateral Forearm Muscle Activity

NCT01097122 | Completed DMC

• 1 other identifier: VGEAH FTR-3
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This study hypothesize that radius subjecting to mechanical loading may affect excitability of alpha motor neuron innervating muscle, based on its bone mineral density or bone mineral content. A total of 80 voluntaries are planned to include in this study. Vibration will be applied the right forearm. Muscle electrical activity will be measured on ipsilateral and contralateral flexor carpi radialis (FCR) muscle at rest as EMGrms by surface electromyography (EMG). The rest-EMGrms will be measured at before and during vibration. An increase in muscle electrical activity at rest indicates an increase in motor neuron pool activation. The right distal radius bone mineral content (BMC) and density will be measured by dual energy X-ray absorptiometry (DXA). The right radius bone mineral density (BMD) and BMC will be evaluated by bone densitometer (GE-LUNAR DPX PRO). Motor unit potentials will be measured by electromyography at left flexor carpi radialis. Neurotrac ETS device will be used.

Conditions

Osteoporosis; Excitability

Keywords

bone; motor neuron excitability; forearm vibration; mechanical loading; muscle electrical activity

Outcome Measures

Primary Outcomes (1)

• Changes in rest muscle electrical activity in the contralateral untrained flexor carpi radialis during the right forearm vibration

  Rest muscle electrical activity changes will be examined in the contralateral untrained flexor carpi radialis during the right forearm vibration

  2 or 3 weeks

Study Arms (1)

Healthy young adult subjects

EXPERIMENTAL

Forearm vibration will be applied in healthy young adult subjects

Procedure: Forearm vibration

Interventions

Forearm vibration PROCEDURE

Mechanical loading with forearm vibration will be applied right radius in all groups

Also known as: Cyclic mechanical loading

Healthy young adult subjects

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy subjects
• Right handed
• Young adult women and men

You may not qualify if:

• secondary osteoporosis
• neuropathy (central or peripheral)
• myopathy
• systemic diseases (arthritis, endocrine-metabolic diseases, bone diseases)
• professional sportswoman/sportsman
• subjects doing regular sports activities
• tendinopathy
• amputee, endoprosthesis, metal implants

Sponsors & Collaborators

• Vakif Gureba Training and Research Hospital: lead

Study Sites (1)

Vakif Gureba Training & Research Hospital

Istanbul, 34000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Osteoporosis

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• ILHAN KARACAN, MD

  Vakif Gureba Training & Research Hospital

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ILHAN KARACAN

Study Record Dates

• First Submitted: March 27, 2010
• First Posted: April 1, 2010
• Study Start: March 1, 2010
• Primary Completion: June 1, 2010
• Study Completion: July 1, 2010
• Last Updated: February 27, 2012

Record last verified: 2012-02

Locations

TU (1)