Etiology of Uncomplicated Fever in Children <5 in Rural Zanzibar

NCT01094431 | Completed DMC

• 1 other identifier: Fever 2010
• Study Type: observational
• Target: 690
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to study the most common etiologies of uncomplicated fever diseases among children under five years of age in rural Zanzibar.

Conditions

Fever; Infectious Disease

Keywords

Fever; Etiology; Children under five years of age; IMCI

Outcome Measures

Primary Outcomes (1)

• relative frequency of febrile diseases etiology

  Five months

Eligibility Criteria

• Age: 2 Months - 59 Months
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Kivunge Primary Health Care Center (PHCC) in North A District in Zanzibar

You may qualify if:

• Patients between 2-59 months of age with confirmed fever, with a measured axillary temperature of ≥37.5˚C, or history of fever within the preceding 24 hours.
• Presenting at the health facility from 8.00 to 16.00 Monday to Friday.
• Informed consent.
• Able and willing to complete stipulated follow-up.

You may not qualify if:

• Decision by the clinician to refer the patient to another health facility than the PHCC where the study is conducted.
• Symptoms/ signs of severe disease that requires immediate referral from the PHCC as defined by the clinicians. These symptoms/signs of severe disease are according to the IMCI guidelines.

Sponsors & Collaborators

• Karolinska University Hospital: lead
• Zanzibar Malaria Control Programme: collaborator
• World Health Organization: collaborator
• Göteborg University: collaborator
• Queen Silvia Children's Hospital, Gothenburg, Sweden: collaborator

Study Sites (1)

Facility: Primary health care center (PHCC), Kivunge, North A district, Zanzibar

Kivunge, Zanzibar, Tanzania

Location

Related Publications (1)

• Elfving K, Stromberg LG, Geravandi S, Andersson M, Bachelard M, Msellem M, Shakely D, Trollfors B, Norden R, Martensson A, Bjorkman A, Lindh M. Pneumococcal concentration and serotype distribution in preschool children with radiologically confirmed pneumonia compared to healthy controls prior to introduction of pneumococcal vaccination in Zanzibar: an observational study. BMC Infect Dis. 2022 Dec 10;22(1):925. doi: 10.1186/s12879-022-07902-5.

  PMID: 36496395 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Urine collected in deep ager Frozen Nasopharyngeal secretions

MeSH Terms

Conditions

Fever; Communicable Diseases

Condition Hierarchy (Ancestors)

Body Temperature Changes; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Infections; Disease Attributes; Pathologic Processes

Study Officials

• Anders Björkman, Professor

  Karolinska University Hopsital

  PRINCIPAL INVESTIGATOR

• Magnus Lindh, Professor

  Sahlgrenska University Hospital

  PRINCIPAL INVESTIGATOR

• Mwinyi Msellem, MSc

  Zanzibar Malaria Control Programme

  PRINCIPAL INVESTIGATOR

• Abdullah S. Ali, Manager

  Zanzibar Malaria Control Programme

  PRINCIPAL INVESTIGATOR

• Birger Trollfors, Professor

  Sahlgrenska University Hospital

  PRINCIPAL INVESTIGATOR

• Andreas Mårtensson, MD, PhD,

  Karolinska University Hospital

  PRINCIPAL INVESTIGATOR

• Kristina Elfving, M.D.

  Sahlgrenska University Hospital

  PRINCIPAL INVESTIGATOR

• Deler Shakely, M.D.

  Karolinska University Hopsital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 26, 2010
• First Posted: March 29, 2010
• Study Start: April 1, 2011
• Primary Completion: July 1, 2011
• Study Completion: July 1, 2011
• Last Updated: December 3, 2014

Record last verified: 2014-12

Locations

TA (1)