Effectiveness Of Rapid Diagnostic Tests in the New Context of Low Malaria Endemicity in Zanzibar
RDTACT
Rapid Malaria Diagnostic Tests in Fever Patients Attending Primary Health Care Facilities in Zanzibar - Effectiveness as Diagnostic and Surveillance Tool in the New Context of Low Malaria Endemicity
1 other identifier
observational
3,890
1 country
1
Brief Summary
The purpose of this study is to study the effectiveness of wide scale RDT use at the primary health care level in previously high malaria endemic area during malaria pre-elimination phase for improved targeting of anti-malarial drugs, malaria surveillance and epidemic alertness.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2010
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 26, 2009
CompletedFirst Posted
Study publicly available on registry
October 27, 2009
CompletedStudy Start
First participant enrolled
May 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2011
CompletedNovember 15, 2011
November 1, 2011
5 months
October 26, 2009
November 14, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Adherence to Rapid diagnostic tests (RDT) result
Five months
Eligibility Criteria
Primary health care units (PHCUs) and Primary health care centres (PHCCs) in North A and Micheweni Districts in Zanzibar
You may qualify if:
- All patients \>2 months of age with confirmed fever, with a measured axillary temperature of ≥37.5˚C, or history of fever within the preceding 24 hours
- Presenting to the health facility from 8.00 to 16.00 Monday to Friday.
- Informed consent
You may not qualify if:
- Previous enrolment in the study within the last 28 days.
- Severe disease that requires immediate referral as defined by the clinician
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Karolinska University Hospitallead
- Zanzibar Malaria Control Programmecollaborator
- World Health Organizationcollaborator
Study Sites (1)
Primary health care centers (PHCC)s and Primary health care units (PHCUs)
Kivunge and Micheweni, Zanzibar, Tanzania
Related Publications (1)
Shakely D, Elfving K, Aydin-Schmidt B, Msellem MI, Morris U, Omar R, Weiping X, Petzold M, Greenhouse B, Baltzell KA, Ali AS, Bjorkman A, Martensson A. The usefulness of rapid diagnostic tests in the new context of low malaria transmission in Zanzibar. PLoS One. 2013 Sep 4;8(9):e72912. doi: 10.1371/journal.pone.0072912. eCollection 2013.
PMID: 24023791DERIVED
Biospecimen
Whole blood collected on Rapid diagnostic tests (RDT)s and Filter paper (FP)
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Anders Björkman, Professor
Karolinska University Hopsital
- PRINCIPAL INVESTIGATOR
Andreas Mårtensson, Ph.D, M.D.
Karolinska University Hospital
- PRINCIPAL INVESTIGATOR
Kristina Elfving, M.D.
Karolinska University Hospital
- PRINCIPAL INVESTIGATOR
Mwinyi Msellem, MSc
Zanzibar Malaria Control Programme
- PRINCIPAL INVESTIGATOR
Delér Shakely, M.D.
Karolinska University Hopsital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
October 26, 2009
First Posted
October 27, 2009
Study Start
May 1, 2010
Primary Completion
October 1, 2010
Study Completion
February 1, 2011
Last Updated
November 15, 2011
Record last verified: 2011-11