Mindfulness Based Relapse Prevention for Stimulant Users

NCT01094223 | Completed DMC

• 1 other identifier: MBRP1R21DA029255-01
• Study Type: interventional
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

The broad, long-term objective of the current research is to improve treatment for stimulant use disorders by augmenting traditional relapse prevention therapy with innovative meditation-based strategies to promote affect regulation skills. Based on Mindfulness-Based Cognitive Therapy for depression (Segal, Teasdale, \& Williams, 2002), Marlatt and colleagues recently developed a manualized intervention for the treatment of substance using populations: Mindfulness Based Relapse Prevention (MBRP). The specific aims of this research are 1) To conduct a pilot randomized clinical trial to assess the feasibility of recruiting and retaining individuals for a large scale study and to determine the effect size of MBRP relative to a health education (ED) control group in stimulant users receiving contingency management (CM).

Conditions

Stimulant Dependence

Keywords

Stimulant; Addiction; Mindfulness; Treatment

Outcome Measures

Primary Outcomes (1)

• Depressive symptoms

  The Beck Depression Inventory (BDI), a well validated self-report measure (Beck, 1967) will be administered at baseline, weekly during treatment, and at follow-up. Both the absolute total scores and change scores will be used for analyses.

  baseline (week 0), weekly during treatment (weeks 1-12), and at follow-up (week 24)

Secondary Outcomes (1)

• HIV Risk behaviors

  baseline (week 0), treatment-end (week 12), and follow up (week 24)

Study Arms (2)

Mindfulness

EXPERIMENTAL

Mindfulness Based Relapse Prevention (MBRP). Meditation based therapy group incorporating relapse prevention skills training.

Behavioral: Mindfulness Based Relapse Prevention

Health Education

ACTIVE COMPARATOR

Health education, psychoeducation group focused on various topics pertaining to physical health

Behavioral: Health Education

Interventions

Mindfulness Based Relapse Prevention BEHAVIORAL

Meditation based therapy group incorporating relapse prevention skills training

Mindfulness

Health Education BEHAVIORAL

Psychoeducation group focused on various topics pertaining to physical health

Health Education

Eligibility Criteria

• Age: 18 Years - 59 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18 to 59
• DSM-IV diagnosis of Stimulant Dependence
• Able to provide informed consent
• Willing and able to participate in study procedures

You may not qualify if:

• Presence of life threatening or unstable medical illness, such as acute pulmonary, cardiovascular, or musculoskeletal disease, that would require treatment or make study participation difficult
• Lack of proficiency in English
• Currently homeless (unless residing in a recovery home for which contact information can be provided)
• Dependence on an illicit substance for which medical detoxification is imminently needed.
• Presence of clinically significant psychiatric symptoms as assessed by MINI, such as psychosis or acute mania, that would require ongoing treatment or make study compliance difficult.

Sponsors & Collaborators

• University of California, Los Angeles: lead

Study Sites (1)

UCLA

Los Angeles, California, 90025, United States

Location

MeSH Terms

Conditions

Behavior, Addictive

Condition Hierarchy (Ancestors)

Compulsive Behavior; Impulsive Behavior; Behavior

Study Officials

• Suzette Glasner, Ph.D.

  University of California, Los Angeles

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 25, 2010
• First Posted: March 26, 2010
• Study Start: April 1, 2010
• Primary Completion: April 1, 2012
• Study Completion: December 1, 2012
• Last Updated: April 29, 2022

Record last verified: 2022-04

Locations

US (1)