Detailed Evaluation of Microchimerism

NCT01094197 | Withdrawn

• 3 other identifiers: 695R01HL0833881R01HL083388
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Individuals who experience traumatic injury often require blood transfusion. In some individuals who receive blood after an injury, white blood cells from a person who donated blood may remain in the body for years, a condition known as microchimerism. This study is designed to examine a group of people who are known to have long-term microchimerism and, through analysis of their blood, determine whether there is evidence that the microchimerism involves blood stem cells that can become any type of blood cell (red blood cells, white blood cells, or platelets) and that might be a permanent part of the body.

Conditions

Chimerism; Blood Transfusion; Wounds and Injuries; Hematopoiesis

Keywords

Transfusion-associated microchimerism; Injuries; Leukocytes

Study Arms (1)

Transfused microchimeric subject

Former trauma patient who underwent blood transfusion and has recent evidence of long-term transfusion-associated microchimerism

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Previous study participants

You may qualify if:

• Demonstrated long-term microchimerism following transfusion for traumatic injury

You may not qualify if:

• Prior bone marrow or solid organ transplantation
• Pregnancy
• Blood transfusion within the past 12 months

Sponsors & Collaborators

• Vitalant Research Institute: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

University of California, Davis, Medical Center

Sacramento, California, 95817, United States

Location

Related Publications (4)

• Utter GH, Owings JT, Lee TH, Paglieroni TG, Reed WF, Gosselin RC, Holland PV, Busch MP. Blood transfusion is associated with donor leukocyte microchimerism in trauma patients. J Trauma. 2004 Oct;57(4):702-7; discussion 707-8. doi: 10.1097/01.ta.0000140666.15972.37.

  PMID: 15514522 BACKGROUND

• Lee TH, Paglieroni T, Utter GH, Chafets D, Gosselin RC, Reed W, Owings JT, Holland PV, Busch MP. High-level long-term white blood cell microchimerism after transfusion of leukoreduced blood components to patients resuscitated after severe traumatic injury. Transfusion. 2005 Aug;45(8):1280-90. doi: 10.1111/j.1537-2995.2005.00201.x.

  PMID: 16078913 BACKGROUND

• Utter GH, Reed WF, Lee TH, Busch MP. Transfusion-associated microchimerism. Vox Sang. 2007 Oct;93(3):188-95. doi: 10.1111/j.1423-0410.2007.00954.x.

  PMID: 17845255 BACKGROUND

• Utter GH, Lee TH, Rivers RM, Montalvo L, Wen L, Chafets DM, Reed WF, Busch MP. Microchimerism decades after transfusion among combat-injured US veterans from the Vietnam, Korean, and World War II conflicts. Transfusion. 2008 Aug;48(8):1609-15. doi: 10.1111/j.1537-2995.2008.01758.x. Epub 2008 May 22.

  PMID: 18503616 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Leukapheresis filtrate and/or whole blood samples

MeSH Terms

Conditions

Wounds and Injuries

Study Officials

• Michael P. Busch, MD, PhD

  Vitalant Research Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 25, 2010
• First Posted: March 26, 2010
• Study Start: March 1, 2010
• Primary Completion: November 1, 2011
• Study Completion: November 1, 2011
• Last Updated: April 12, 2013

Record last verified: 2013-04

Locations

US (1)