Transfusion-Associated Microchimerism in Individuals Receiving a Blood Transfusion After a Traumatic Injury

NCT00400192 | Completed

• 2 other identifiers: 1362R01HL083388
• Study Type: observational
• Target: 451
• Locations: 1 country
• Sites: 1

Brief Summary

Individuals who experience a traumatic injury often have a significant amount of blood loss and may require a blood transfusion. In some individuals who receive a blood transfusion, white blood cells from the donor's blood may remain in the body for years, a condition known as microchimerism. This study will examine the reasons why microchimerism occurs in some blood transfusion recipients and not others.

Conditions

Chimerism; Blood Transfusion; Wounds and Injuries

Keywords

Microchimerism; Injuries; Leukocytes; Immunologic Techniques

Outcome Measures

Primary Outcomes (1)

• Prevalence and magnitude of transfusion-associated microchimerism

  1, 2 and 4 weeks, 3 and 6 months

Eligibility Criteria

• Age: 12 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Emergency Department

You may qualify if:

• Hospitalized for a traumatic injury
• Received at least one unit of transfused red blood cells

You may not qualify if:

• Currently incarcerated
• Inadequate decision-making capacity of the participant and no available surrogate decision-maker
• Prior bone marrow or solid organ transplantation

Sponsors & Collaborators

• Vitalant Research Institute: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

University of California, Davis, Medical Center

Sacramento, California, 95817, United States

Location

Related Publications (3)

• Utter GH, Owings JT, Lee TH, Paglieroni TG, Reed WF, Gosselin RC, Holland PV, Busch MP. Blood transfusion is associated with donor leukocyte microchimerism in trauma patients. J Trauma. 2004 Oct;57(4):702-7; discussion 707-8. doi: 10.1097/01.ta.0000140666.15972.37.

  PMID: 15514522 BACKGROUND

• Utter GH, Owings JT, Lee TH, Paglieroni TG, Reed WF, Gosselin RC, Holland PV, Busch MP. Microchimerism in transfused trauma patients is associated with diminished donor-specific lymphocyte response. J Trauma. 2005 May;58(5):925-31; discussion 931-2. doi: 10.1097/01.ta.0000162142.72817.5c.

  PMID: 15920405 BACKGROUND

• Lee TH, Paglieroni T, Utter GH, Chafets D, Gosselin RC, Reed W, Owings JT, Holland PV, Busch MP. High-level long-term white blood cell microchimerism after transfusion of leukoreduced blood components to patients resuscitated after severe traumatic injury. Transfusion. 2005 Aug;45(8):1280-90. doi: 10.1111/j.1537-2995.2005.00201.x.

  PMID: 16078913 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood, plasma, peripheral blood mononuclear cells

MeSH Terms

Conditions

Wounds and Injuries

Study Officials

• Michael P. Busch, MD, PhD

  Vitalant Research Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 15, 2006
• First Posted: November 16, 2006
• Study Start: November 1, 2006
• Primary Completion: August 1, 2010
• Study Completion: July 1, 2012
• Last Updated: April 15, 2013

Record last verified: 2013-04

Locations

US (1)