To Determine if a Lower Extremity Strengthening Program Improve Quadriceps Muscle Strength

NCT01080703 | Completed

• 2 other identifiers: 10-076-BPULMONARY
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine if a lower extremity strengthening program as part of pulmonary rehabilitation will improve quadriceps muscle strength, endurance and functional status as well as overall quality of life. Hypothesis:

1. 1.Lower extremity resistance training as part of a pulmonary rehabilitation program will improve quadriceps strength, endurance and functional capacity.
2. 2.Lower extremity resistance training as part of a pulmonary rehabilitation program will improve quality of life in patients awaiting lung transplant.

Conditions

Pulmonary Disease

Keywords

Lung Transplant; Quadriceps Strength; Quality of Life; Patients with pulmonary disease awaiting lung transplant.

Outcome Measures

Primary Outcomes (1)

• Quadriceps Strength

  Quadriceps Strength will be assessed at initial evaluation and subsequently every two weeks for 10 weeks. Testing will be done at 30, 60 and 90 degrees of knee flexion using hand held dynamometer. The six miute walk test is also used as a primary outcomes to assess endurance. It will be done at initial evaluation, 5 weeks and 10 weeks.

  10 weeks

Secondary Outcomes (1)

• Quality of Life Survey

  10 weeks

Study Arms (1)

Lower extremity strengthening

EXPERIMENTAL

Other: Exercise

Interventions

Exercise OTHER

Lower extremity resistance exercises and aerobic exercises 3 times a week in 10 week pulmonary rehabilitation program prior to lung transplant.

Lower extremity strengthening

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients preparing for lung transplant
• Diagnoses included are: Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis, Sarcoidosis, Cystic Fibrosis, or Bronchiectasis

You may not qualify if:

• Primary Pulmonary Hypertension
• Multi-organ transplant patients
• Re-transplant patients
• Patients requiring intubation greater than or equal to 7 days prior to transplant
• Any orthopedic condition which will prevent from participation in a lower extremity strengthening program

Sponsors & Collaborators

• University of Chicago: lead

Study Sites (1)

The University of Chicago Medical Center

Chicago, Illinois, 60637, United States

Location

MeSH Terms

Conditions

Lung Diseases

Interventions

Exercise

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Edward R Garrity, MD

  University of Chicago

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 2, 2010
• First Posted: March 4, 2010
• Study Start: March 1, 2010
• Primary Completion: January 1, 2014
• Study Completion: January 1, 2014
• Last Updated: December 4, 2014

Record last verified: 2014-12

Locations

US (1)