NCT01079221

Brief Summary

COPD patients have a reduced exercise tolerance due to a ventilatory limitation. Several studies have shown altered skeletal muscle function. The investigator will study the physiological response to knee-extensor exercise in COPD patients.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for not_applicable chronic-obstructive-pulmonary-disease

Timeline
Completed

Started Feb 2009

Longer than P75 for not_applicable chronic-obstructive-pulmonary-disease

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2009

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

March 2, 2010

Completed
1 day until next milestone

First Posted

Study publicly available on registry

March 3, 2010

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2010

Completed
2.5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2012

Completed
Last Updated

August 2, 2016

Status Verified

August 1, 2016

Enrollment Period

1.3 years

First QC Date

March 2, 2010

Last Update Submit

August 1, 2016

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

exerciseKnee extensor

Outcome Measures

Primary Outcomes (1)

  • Peak power

    At inclusion and after 6 weeks of training

Secondary Outcomes (1)

  • Mitochondrial respiration, Vmax

    At inclusion and after 6 weeks of training

Study Arms (1)

Knee extensor exercise training

EXPERIMENTAL

High intensity aerobic knee-extensor exercise training

Behavioral: High intensity knee-extensor training

Interventions

High intensity knee-extensor trainingBEHAVIORAL

High intensity aerobic knee-extensor exercise training, 4x 3 minutes interval training at \< 90 % of peak power, 3 days/week for 6 weeks

Knee extensor exercise training

Eligibility Criteria

Age50 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • COPD diagnosis with FEV1\<70% exp, FEV1%FVC \<70 %
  • Age\> 50 years

You may not qualify if:

  • Heart failure
  • Symptomatic coronary artery disease
  • Cancer
  • Alcohol and drug abuse
  • Severe mental illness
  • Lower respiratory illness
  • Participation in exercise- or lung rehabilitation program last 3 months
  • pregnancy
  • oral steroid use

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Bronstad E, Rognmo O, Tjonna AE, Dedichen HH, Kirkeby-Garstad I, Haberg AK, Ingul CB, Wisloff U, Steinshamn S. High-intensity knee extensor training restores skeletal muscle function in COPD patients. Eur Respir J. 2012 Nov;40(5):1130-6. doi: 10.1183/09031936.00193411. Epub 2012 Mar 9.

    PMID: 22408206RESULT

MeSH Terms

Conditions

Pulmonary Disease, Chronic ObstructiveMotor Activity

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and SymptomsBehavior

Study Officials

  • Ulrik Wisløff, PhD prof.

    Norwegian University of Science and Technology

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 2, 2010

First Posted

March 3, 2010

Study Start

February 1, 2009

Primary Completion

June 1, 2010

Study Completion

December 1, 2012

Last Updated

August 2, 2016

Record last verified: 2016-08