The LIFE Study - Lifestyle Interventions and Independence for Elders

NCT01072500 | Completed Phase 3 Results DMC

• 3 other identifiers: IRB201701066-N3U01AG022376-05A2S1U01AG022376
• Study Type: interventional
• Target: 1,635
• Locations: 1 country
• Sites: 8

Brief Summary

Based upon promising results from a pilot study among 424 sedentary older adults who were randomized to a physical activity intervention or a successful aging health education intervention, a Phase 3 multi-center randomized controlled trial is being conducted to compare a moderate-intensity physical activity program to a successful aging health education program in 1,600 sedentary older adults who are followed for an average of 2.7 years. The primary aim was to assess the long-term effects of the proposed interventions on the primary outcome of major mobility disability, defined as inability to walk 400 m.

Conditions

Sedentary Lifestyle; Risk of Disability; Aging

Keywords

Aging; Physical Activity; Exercise; Sedentary Lifestyle; Mobility; Disability; Falls; Cost effectiveness; Behavioral counseling

Outcome Measures

Primary Outcomes (1)

• Major Mobility Disability, Defined as Incapacity to Walk 400 Meters

  The primary outcome of major mobility disability was defined as the inability to complete a 400-m walk test within 15 minutes without sitting and without the help of another person or walker. Use of a cane was acceptable. Participants were asked to walk 400 m at their usual pace, without overexerting, on a 20 meter course for 10 laps (40 meters/lap). Participants were allowed to stop for up to 1 minute for fatigue or related symptoms. When major mobility disability could not be objectively measured because of the inability of the participant to come to the clinic and absence of a suitable walking course at the participant's home, institution, or hospital, an alternative adjudication of the outcome was based on objective inability to walk 4 meters in less than 10 seconds, or self-, proxy-, or medical record-reported inability to walk across a room. If participants met these alternative criteria, they would not be able to complete the 400 meter walk within 15 minutes.

  Median 2.7 years/Average 2.6 years

Secondary Outcomes (1)

• Persistent Mobility Disability (Assessed Every 6 Months)

  Median 2.7 years/Average 2.6 years

Study Arms (2)

Physical Activity

ACTIVE COMPARATOR

The physical activity intervention consists primarily of walking at moderate intensity, lower extremity resistance exercises, balance exercises, stretching and behavioral counseling.

Behavioral: Physical Activity

Successful Aging

ACTIVE COMPARATOR

The successful aging intervention consists of health education seminars regarding health-related matters and upper extremity stretching exercises.

Behavioral: Successful Aging

Interventions

Physical Activity BEHAVIORAL

The physical activity intervention consists primarily of walking at moderate intensity, lower extremity resistance exercises, balance exercises, stretching and behavioral counseling.

Physical Activity

Successful Aging BEHAVIORAL

The successful aging intervention consists of health education seminars regarding health-related matters and upper extremity stretching exercises.

Also known as: Health Education

Successful Aging

Eligibility Criteria

• Age: 70 Years - 89 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• age 70 to 89 years; (2) summary score \<10 on the short physical performance battery (SPPB) (45% are \<8);90 (3) sedentary lifestyle; (4) ability to complete the 400 m walk test without an assistive device; and (5) willingness to be randomized to either intervention group.

You may not qualify if:

• Current consumption of more than 14 alcoholic drinks per week
• Plans to relocate to out of the study area within the next 2 years or plans to be out of the study area for more than 6 consecutive weeks in the next year
• Self-reported inability to walk across a small room
• The use of a walker to complete the 400 m walk and/or unable to complete the 400 m walk without sitting down or the help of another person
• Another member of the household is a participant in the Life Study
• Residence too far from the intervention site
• Residence in a nursing home
• Difficulty in communication with study personnel due to speech or hearing problems
• Modified Mini-Mental State Exam (3MSE) score below the cutoff for education:
• African American, 9+ yrs 76, \<9 yrs 70; English Speaking Non-African American, 9+ yrs 80, \<9 yrs 76; Spanish Speaking, 9+ yrs 80, \<9 yrs 70
• Participation in LIFE-Pilot study
• Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol
• Severe arthritis (either osteoarthritis or rheumatoid arthritis)
• Cancer requiring treatment in the past three years, except for non-melanoma skin cancers or cancers that have clearly been cured or in the opinion of the investigator carry an excellent prognosis (e.g., Stage 1 cervical cancer)
• Lung disease requiring either regular use of corticosteroid pills or injections or the use of supplemental oxygen

Sponsors & Collaborators

• University of Florida: lead
• National Institute on Aging (NIA): collaborator
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (8)

Stanford University

Palo Alto, California, 94304, United States

Location

Yale University

New Haven, Connecticut, 06510, United States

Location

University of Florida

Gainesville, Florida, 32608, United States

Location

Northwestern University

Chicago, Illinois, 60611, United States

Location

Pennington Biodmedical Research

Baton Rouge, Louisiana, 70808, United States

Location

Tufts University

Boston, Massachusetts, 02111, United States

Location

Wake Forest University Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States

Location

University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States

Location

Related Publications (39)

• LIFE Study Investigators; Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, Hadley EC, King AC, Kritchevsky SB, Maraldi C, Miller ME, Newman AB, Rejeski WJ, Romashkan S, Studenski S. Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1157-65. doi: 10.1093/gerona/61.11.1157.

  PMID: 17167156 BACKGROUND

• Fielding RA, Rejeski WJ, Blair S, Church T, Espeland MA, Gill TM, Guralnik JM, Hsu FC, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M; LIFE Research Group. The Lifestyle Interventions and Independence for Elders Study: design and methods. J Gerontol A Biol Sci Med Sci. 2011 Nov;66(11):1226-37. doi: 10.1093/gerona/glr123. Epub 2011 Aug 8.

  PMID: 21825283 BACKGROUND

• Rejeski WJ, Marsh AP, Anton S, Chen SH, Church T, Gill TM, Guralnik JM, Glynn NW, King AC, Rushing J, Ip EH; LIFE Research Group. The MAT-sf: clinical relevance and validity. J Gerontol A Biol Sci Med Sci. 2013 Dec;68(12):1567-74. doi: 10.1093/gerona/glt068. Epub 2013 May 17.

  PMID: 23685766 RESULT

• Espeland MA, Katula JA, Rushing J, Kramer AF, Jennings JM, Sink KM, Nadkarni NK, Reid KF, Castro CM, Church T, Kerwin DR, Williamson JD, Marottoli RA, Rushing S, Marsiske M, Rapp SR; LIFE Study Group. Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors. Int J Geriatr Psychiatry. 2013 Dec;28(12):1239-50. doi: 10.1002/gps.3949. Epub 2013 Apr 16.

  PMID: 23589390 RESULT

• Marsh AP, Lovato LC, Glynn NW, Kennedy K, Castro C, Domanchuk K, McDavitt E, Rodate R, Marsiske M, McGloin J, Groessl EJ, Pahor M, Guralnik JM; LIFE Study Research Group. Lifestyle interventions and independence for elders study: recruitment and baseline characteristics. J Gerontol A Biol Sci Med Sci. 2013 Dec;68(12):1549-58. doi: 10.1093/gerona/glt064. Epub 2013 May 28.

  PMID: 23716501 RESULT

• McDermott MM, Applegate WB, Bonds DE, Buford TW, Church T, Espeland MA, Gill TM, Guralnik JM, Haskell W, Lovato LC, Pahor M, Pepine CJ, Reid KF, Newman A. Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study. J Am Heart Assoc. 2013 Nov 12;2(6):e000257. doi: 10.1161/JAHA.113.000257.

  PMID: 24222666 RESULT

• Rejeski WJ, Axtell R, Fielding R, Katula J, King AC, Manini TM, Marsh AP, Pahor M, Rego A, Tudor-Locke C, Newman M, Walkup MP, Miller ME; LIFE Study Investigator Group. Promoting physical activity for elders with compromised function: the lifestyle interventions and independence for elders (LIFE) study physical activity intervention. Clin Interv Aging. 2013;8:1119-31. doi: 10.2147/CIA.S49737. Epub 2013 Sep 12.

  PMID: 24049442 RESULT

• Levati E, Zazzara MB, Iurlaro A, Marzetti E, Calvani R, Pahor M, Picca A, Tosato M, Landi F, Bernabei R, Onder G. Lifestyle interventions and medication burden in older adults: insights from the Lifestyle Intervention and Independence for Elders (LIFE) and the Sarcopenia and Physical fRailty iN older people: multi-componenT Treatment strategies (SPRINTT) trials. Eur Geriatr Med. 2025 Oct;16(5):1591-1598. doi: 10.1007/s41999-025-01266-0. Epub 2025 Jul 15.

  PMID: 40665144 DERIVED

• Fielding RA, Atkinson EJ, Aversa Z, White TA, Heeren AA, Mielke MM, Cummings SR, Pahor M, Leeuwenburgh C, LeBrasseur NK. Biomarkers of Cellular Senescence Predict the Onset of Mobility Disability and Are Reduced by Physical Activity in Older Adults. J Gerontol A Biol Sci Med Sci. 2024 Mar 1;79(3):glad257. doi: 10.1093/gerona/glad257.

  PMID: 37948612 DERIVED

• Custodero C, Agosti P, Anton SD, Manini TM, Lozupone M, Panza F, Pahor M, Sabba C, Solfrizzi V. Effect of Physical Activity Intervention on Gait Speed by Frailty Condition: A Randomized Clinical Trial. J Am Med Dir Assoc. 2023 Apr;24(4):489-496. doi: 10.1016/j.jamda.2023.01.023. Epub 2023 Mar 3.

  PMID: 36878264 DERIVED

• Fielding RA, Atkinson EJ, Aversa Z, White TA, Heeren AA, Achenbach SJ, Mielke MM, Cummings SR, Pahor M, Leeuwenburgh C, LeBrasseur NK. Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study. Geroscience. 2022 Dec;44(6):2757-2770. doi: 10.1007/s11357-022-00685-2. Epub 2022 Nov 11.

  PMID: 36367600 DERIVED

• Shlipak MG, Sheshadri A, Hsu FC, Chen SH, Jotwani V, Tranah G, Fielding RA, Liu CK, Ix J, Coca SG; LIFE Investigators. Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults: An Ancillary Analysis of the LIFE Study Randomized Clinical Trial. JAMA Intern Med. 2022 Jun 1;182(6):650-659. doi: 10.1001/jamainternmed.2022.1449.

  PMID: 35499834 DERIVED

• Botoseneanu A, Chen H, Ambrosius WT, Allore HG, Anton S, Folta SC, King AC, Nicklas BJ, Spring B, Strotmeyer ES, Gill TM. Metabolic syndrome and the benefit of a physical activity intervention on lower-extremity function: Results from a randomized clinical trial. Exp Gerontol. 2021 Jul 15;150:111343. doi: 10.1016/j.exger.2021.111343. Epub 2021 Apr 10.

  PMID: 33848565 DERIVED

• Fanning J, Rejeski WJ, Chen SH, Guralnik J, Pahor M, Miller ME. Relationships Between Profiles of Physical Activity and Major Mobility Disability in the LIFE Study. J Am Geriatr Soc. 2020 Jul;68(7):1476-1483. doi: 10.1111/jgs.16386. Epub 2020 Mar 20.

  PMID: 32196636 DERIVED

• Fanning J, Rejeski WJ, Chen SH, Nicklas BJ, Walkup MP, Axtell RS, Fielding RA, Glynn NW, King AC, Manini TM, McDermott MM, Newman AB, Pahor M, Tudor-Locke C, Miller ME; LIFE Study Investigators. A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2019 Oct 4;74(11):1821-1827. doi: 10.1093/gerona/glz050.

  PMID: 30778518 DERIVED

• Liu Z, Hsu FC, Trombetti A, King AC, Liu CK, Manini TM, Fielding RA, Pahor M, Newman AB, Kritchevsky S, Gill TM; LIFE Study investigators. Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial. BMC Med. 2018 Oct 24;16(1):185. doi: 10.1186/s12916-018-1174-8.

  PMID: 30352583 DERIVED

• Datta R, Trentalange M, Van Ness PH, McGloin JM, Guralnik JM, Miller ME, Walkup MP, Nadkarni N, Pahor M, Gill TM, Quagliarello V, Juthani-Mehta M; LIFE Study Group. Serious adverse events of older adults in nursing home and community intervention trials. Contemp Clin Trials Commun. 2017 Dec 21;9:77-80. doi: 10.1016/j.conctc.2017.12.004. eCollection 2018 Mar.

  PMID: 29696228 DERIVED

• Rosso AL, Metti AL, Glynn NW, Boudreau RM, Rejeski WJ, Bohnen N, Chen H, Johannsen NM, King AC, Manini TM, Pahor M, Studenski SA, Fragoso CAV, Rosano C; LIFE Study Group. Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study. J Am Geriatr Soc. 2018 Jul;66(6):1172-1179. doi: 10.1111/jgs.15369. Epub 2018 Apr 10.

  PMID: 29637543 DERIVED

• Cochrane SK, Chen SH, Fitzgerald JD, Dodson JA, Fielding RA, King AC, McDermott MM, Manini TM, Marsh AP, Newman AB, Pahor M, Tudor-Locke C, Ambrosius WT, Buford TW; LIFE Study Research Group. Association of Accelerometry-Measured Physical Activity and Cardiovascular Events in Mobility-Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study. J Am Heart Assoc. 2017 Dec 2;6(12):e007215. doi: 10.1161/JAHA.117.007215.

  PMID: 29197830 DERIVED

• Kritchevsky SB, Lovato L, Handing EP, Blair S, Botoseneanu A, Guralnik JM, Liu C, King A, Marsh AP, Pahor M, Rejeski WJ, Spring B, Manini T. Exercise's effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial. Obesity (Silver Spring). 2017 Jul;25(7):1199-1205. doi: 10.1002/oby.21860.

  PMID: 28653499 DERIVED

• Gill TM, Beavers DP, Guralnik JM, Pahor M, Fielding RA, Hauser M, Manini TM, Marsh AP, McDermott MM, Newman AB, Allore HG, Miller ME; LIFE Study Investigators. The effect of intervening hospitalizations on the benefit of structured physical activity in promoting independent mobility among community-living older persons: secondary analysis of a randomized controlled trial. BMC Med. 2017 Mar 28;15(1):65. doi: 10.1186/s12916-017-0824-6.

  PMID: 28347337 DERIVED

• King AC, Salvo D, Banda JA, Ahn DK, Chapman JE, Gill TM, Fielding RA, Demons J, Tudor-Locke C, Rosso A, Pahor M, Frank LD. Preserving older adults' routine outdoor activities in contrasting neighborhood environments through a physical activity intervention. Prev Med. 2017 Mar;96:87-93. doi: 10.1016/j.ypmed.2016.12.049. Epub 2016 Dec 28.

  PMID: 28039068 DERIVED

• O Hartaigh B, Lovato LC, Pahor M, Buford TW, Dodson JA, Forman DE, Buman MP, Demons JL, Santanasto AJ, Liu C, Miller ME, McDermott MM, Gill TM; LIFE Study Group. Effect of a Long-Term Physical Activity Intervention on Resting Pulse Rate in Older Persons: Results from the Lifestyle Interventions and Independence for Elders Study. J Am Geriatr Soc. 2016 Dec;64(12):2511-2516. doi: 10.1111/jgs.14380. Epub 2016 Oct 27.

  PMID: 27787876 DERIVED

• Gill TM, Guralnik JM, Pahor M, Church T, Fielding RA, King AC, Marsh AP, Newman AB, Pellegrini CA, Chen SH, Allore HG, Miller ME; LIFE Study Investigators. Effect of Structured Physical Activity on Overall Burden and Transitions Between States of Major Mobility Disability in Older Persons: Secondary Analysis of a Randomized Trial. Ann Intern Med. 2016 Dec 20;165(12):833-840. doi: 10.7326/M16-0529. Epub 2016 Sep 27.

  PMID: 27669457 DERIVED

• Marsh AP, Applegate WB, Guralnik JM, Jack Rejeski W, Church TS, Fielding RA, Gill TM, King AC, Kritchevsky SB, Manini TM, McDermott MM, Newman AB, Stowe CL, Walkup MP, Pahor M, Miller ME; LIFE Study Investigators. Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. J Am Geriatr Soc. 2016 May;64(5):933-43. doi: 10.1111/jgs.14114.

  PMID: 27225353 DERIVED

• Bann D, Chen H, Bonell C, Glynn NW, Fielding RA, Manini T, King AC, Pahor M, Mihalko SL, Gill TM; Life Study investigators. Socioeconomic differences in the benefits of structured physical activity compared with health education on the prevention of major mobility disability in older adults: the LIFE study. J Epidemiol Community Health. 2016 Sep;70(9):930-3. doi: 10.1136/jech-2016-207321. Epub 2016 Apr 8.

  PMID: 27060177 DERIVED

• Vaz Fragoso CA, Beavers DP, Anton SD, Liu CK, McDermott MM, Newman AB, Pahor M, Stafford RS, Gill TM; Lifestyle Interventions and Independence in Elders Investigators. Effect of Structured Physical Activity on Respiratory Outcomes in Sedentary Elderly Adults with Mobility Limitations. J Am Geriatr Soc. 2016 Mar;64(3):501-9. doi: 10.1111/jgs.14013.

  PMID: 27000324 DERIVED

• Groessl EJ, Kaplan RM, Castro Sweet CM, Church T, Espeland MA, Gill TM, Glynn NW, King AC, Kritchevsky S, Manini T, McDermott MM, Reid KF, Rushing J, Pahor M; LIFE Study Group. Cost-effectiveness of the LIFE Physical Activity Intervention for Older Adults at Increased Risk for Mobility Disability. J Gerontol A Biol Sci Med Sci. 2016 May;71(5):656-62. doi: 10.1093/gerona/glw001. Epub 2016 Feb 17.

  PMID: 26888433 DERIVED

• Gill TM, Pahor M, Guralnik JM, McDermott MM, King AC, Buford TW, Strotmeyer ES, Nelson ME, Sink KM, Demons JL, Kashaf SS, Walkup MP, Miller ME; LIFE Study Investigators. Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study). BMJ. 2016 Feb 3;352:i245. doi: 10.1136/bmj.i245.

  PMID: 26842425 DERIVED

• King AC, Salvo D, Banda JA, Ahn DK, Gill TM, Miller M, Newman AB, Fielding RA, Siordia C, Moore S, Folta S, Spring B, Manini T, Pahor M; LIFE Study Investigators. An observational study identifying obese subgroups among older adults at increased risk of mobility disability: do perceptions of the neighborhood environment matter? Int J Behav Nutr Phys Act. 2015 Dec 18;12:157. doi: 10.1186/s12966-015-0322-1.

  PMID: 26684894 DERIVED

• Sink KM, Espeland MA, Castro CM, Church T, Cohen R, Dodson JA, Guralnik J, Hendrie HC, Jennings J, Katula J, Lopez OL, McDermott MM, Pahor M, Reid KF, Rushing J, Verghese J, Rapp S, Williamson JD; LIFE Study Investigators. Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial. JAMA. 2015 Aug 25;314(8):781-90. doi: 10.1001/jama.2015.9617.

  PMID: 26305648 DERIVED

• Vaz Fragoso CA, Miller ME, King AC, Kritchevsky SB, Liu CK, Myers VH, Nadkarni NK, Pahor M, Spring BJ, Gill TM; Lifestyle Interventions and Independence for Elders Study Group. Effect of Structured Physical Activity on Sleep-Wake Behaviors in Sedentary Elderly Adults with Mobility Limitations. J Am Geriatr Soc. 2015 Jul;63(7):1381-90. doi: 10.1111/jgs.13509. Epub 2015 Jun 26.

  PMID: 26115386 DERIVED

• Espeland MA, Newman AB, Sink K, Gill TM, King AC, Miller ME, Guralnik J, Katula J, Church T, Manini T, Reid KF, McDermott MM; LIFE Study Group. Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial. J Am Med Dir Assoc. 2015 Aug 1;16(8):682-9. doi: 10.1016/j.jamda.2015.03.010. Epub 2015 Apr 11.

  PMID: 25869993 DERIVED

• Fitzgerald JD, Johnson L, Hire DG, Ambrosius WT, Anton SD, Dodson JA, Marsh AP, McDermott MM, Nocera JR, Tudor-Locke C, White DK, Yank V, Pahor M, Manini TM, Buford TW; LIFE Study Research Group. Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults. J Am Heart Assoc. 2015 Feb 18;4(2):e001288. doi: 10.1161/JAHA.114.001288.

  PMID: 25696062 DERIVED

• Bann D, Hire D, Manini T, Cooper R, Botoseneanu A, McDermott MM, Pahor M, Glynn NW, Fielding R, King AC, Church T, Ambrosius WT, Gill TM; LIFE Study Group. Light Intensity physical activity and sedentary behavior in relation to body mass index and grip strength in older adults: cross-sectional findings from the Lifestyle Interventions and Independence for Elders (LIFE) study. PLoS One. 2015 Feb 3;10(2):e0116058. doi: 10.1371/journal.pone.0116058. eCollection 2015.

  PMID: 25647685 DERIVED

• Vaz Fragoso CA, Hsu FC, Brinkley T, Church T, Liu CK, Manini T, Newman AB, Stafford RS, McDermott MM, Gill TM; LIFE Study Group. Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations. J Am Med Dir Assoc. 2014 Sep;15(9):665-70. doi: 10.1016/j.jamda.2014.05.008. Epub 2014 Jun 25.

  PMID: 24973990 DERIVED

• Vaz Fragoso CA, Miller ME, Fielding RA, King AC, Kritchevsky SB, McDermott MM, Myers V, Newman AB, Pahor M, Gill TM; Lifestyle Interventions and Independence in Elder Study Group. Sleep-wake disturbances in sedentary community-dwelling elderly adults with functional limitations. J Am Geriatr Soc. 2014 Jun;62(6):1064-72. doi: 10.1111/jgs.12845. Epub 2014 Jun 2.

  PMID: 24889836 DERIVED

• Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD; LIFE study investigators. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA. 2014 Jun 18;311(23):2387-96. doi: 10.1001/jama.2014.5616.

  PMID: 24866862 DERIVED

• Vaz Fragoso CA, Beavers DP, Hankinson JL, Flynn G, Berra K, Kritchevsky SB, Liu CK, McDermott MM, Manini TM, Rejeski WJ, Gill TM; Lifestyle Interventions Independence for Elders Study Investigators. Respiratory impairment and dyspnea and their associations with physical inactivity and mobility in sedentary community-dwelling older persons. J Am Geriatr Soc. 2014 Apr;62(4):622-8. doi: 10.1111/jgs.12738. Epub 2014 Mar 17.

  PMID: 24635756 DERIVED

Related Links

• The LIFE Study website

MeSH Terms

Conditions

Sedentary Behavior; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Results Point of Contact

• Title: Michael Miller
• Organization: Wake Forest School of Medicine

mmiller@wakehealth.edu

336-716-6837

Study Officials

• Marco Pahor, MD

  University of Florida

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 19, 2010
• First Posted: February 22, 2010
• Study Start: February 1, 2010
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2014
• Last Updated: May 7, 2018
• Results First Posted: April 18, 2016

Record last verified: 2018-04

Data Sharing

• IPD Sharing: Will share

Locations

US (8)