Exercise, Executive Processes and the Aging Brain

NCT00430976 | Completed Phase 3

• 2 other identifiers: IA01015R01AG021188-03
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to assess the effect of aerobic exercise on the brain and cognition through the measurement of neuroelectric and behavioral indices of executive control cognitive function in older adults.

Conditions

Cognition; Aging

Keywords

psychomotor function; neuromuscular system; memory; brain electrical activity; Mental Processes

Outcome Measures

Primary Outcomes (3)

• Changes in event-related brain potentials

• reaction time

• response accuracy

Secondary Outcomes (1)

• aerobic fitness

Interventions

Minds in Motion BEHAVIORAL

Eligibility Criteria

• Age: 60 Years - 74 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years of age
• Sedentary (no physical activity in 6 last months)
• Capable of performing exercise
• Personal physician's examination and consent to participate in testing and exercise or control intervention
• Successful completion of graded exercise test without evidence of cardiac abnormalities or responses
• Adequate performance on the Mental Status measure
• Corrected (near and far) acuity 20/40 or better
• Initial depression score on GDS below clinical level
• Not previously committed to leaving the Champaign County area for more than 1 month during the intervention period

You may not qualify if:

• Below 60 years of age
• Regular self-reported physical activity (2 times per week) in last six months
• Any physical disability that prohibits mobility (walking), stretching etc.
• Non-consent of physician
• Evidence of abnormal cardiac responses or conditions during graded exercise testing
• Three or more errors on the Mental Status measure
• Corrected (near and far) acuity of greater than 20/40
• Depression score on GDS indicative of clinical depression
• Committed to leaving the Champaign County area for longer than 1 month during the intervention period

Sponsors & Collaborators

• National Institute on Aging (NIA): lead

Study Sites (1)

University of Illinois at Urbana-Champaign

Urbana, Illinois, 61801, United States

Location

Related Publications (3)

• Themanson JR, Hillman CH, Curtin JJ. Age and physical activity influences on action monitoring during task switching. Neurobiol Aging. 2006 Sep;27(9):1335-45. doi: 10.1016/j.neurobiolaging.2005.07.002. Epub 2005 Aug 15.

  PMID: 16102874 BACKGROUND

• Hillman CH, Motl RW, Pontifex MB, Posthuma D, Stubbe JH, Boomsma DI, de Geus EJC. Physical activity and cognitive function in a cross-section of younger and older community-dwelling individuals. Health Psychol. 2006 Nov;25(6):678-687. doi: 10.1037/0278-6133.25.6.678.

  PMID: 17100496 BACKGROUND

• Hillman CH, Kramer AF, Belopolsky AV, Smith DP. A cross-sectional examination of age and physical activity on performance and event-related brain potentials in a task switching paradigm. Int J Psychophysiol. 2006 Jan;59(1):30-9. doi: 10.1016/j.ijpsycho.2005.04.009.

  PMID: 16413382 BACKGROUND

MeSH Terms

Interventions

Motion

Intervention Hierarchy (Ancestors)

Physical Phenomena

Study Officials

• Charles H. Hillman, PhD

  University of Illinois at Urbana-Champaign

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NIH

Study Record Dates

• First Submitted: January 31, 2007
• First Posted: February 2, 2007
• Study Start: December 1, 2006
• Primary Completion: May 1, 2007
• Study Completion: May 1, 2007
• Last Updated: December 11, 2009

Record last verified: 2008-08

Locations

US (1)