Malaria Survey in Mbarara District, Uganda 2010

NCT01062386 | Completed

• 1 other identifier: Epicentre/Mba/2010/MalPrev
• Study Type: observational
• Target: 2,320
• Locations: 1 country
• Sites: 1

Brief Summary

Malaria is one of the major public health problems in Sub-Saharan Africa. In response to this threat, Roll Back Malaria (RBM) has rolled back a strategy using ACT as first line therapy for malaria episode, a wide distribution of Insecticide Treated Bednet (ITN), intermittent presumptive treatment of pregnant women and indoor residual spraying. Recent epidemiological observations suggested a decline in malaria prevalence in some countries but further evidences are still needed to confirm this evolution. The RBM strategy requires the use of reliable rapid diagnostic test (RDT) for which an operational assessment is necessary. Lastly, home-based management of malaria is also an important compound of this strategy. However, a better understanding of the actual use of antimalarial drugs, of the use of bednet and of the barrier to the use of health care is important to implement good quality strategies for malaria control. This study is a cross-sectional community based survey made of two rounds (one in January 2010 and the second in June 2010). The general objective is to measure the prevalence of infection with Plasmodium falciparum at two periods of the year (at the moment of lowest and highest transmission based on the seasonal rainfalls) and to compare it with the prevalence estimated in 2004 after the rainy season for the same area. Specific objective are the estimation of the prevalence by age stratum, the analysis of the geographical distribution of the infection, the description of the parasitological characteristics, the assessment of three RDT, the description and the analysis of the prevention and care seek behaviours related to malaria. The study area is the great Mbarara district located in south-west of Uganda. A three-stage cluster sampling method will be used. Spatial information will be collected with global positioning system and imported to Geographical Information System. Behaviour information will be collected through face to face interview.

Conditions

Malaria

Keywords

prevalence; transmission; knowledge; attitude; practice

Outcome Measures

Primary Outcomes (1)

• Proportion of malaria infections in children under 5 years of age

  January-February 2010

Secondary Outcomes (1)

• Proportion of families with knowledge, attitude and practice regarding malaria prevention

  January-February 2010

Eligibility Criteria

• Age: 1 Month - 59 Months
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Children living in Great Mbarara district

You may qualify if:

• Males and females
• Ages 1 month to 59 months

You may not qualify if:

• None

Sponsors & Collaborators

• Epicentre: lead
• Medecins Sans Frontieres, Netherlands: collaborator

Study Sites (1)

Greater Mbarara district

Mbarara, Mbarara, Uganda

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood sample for: Malaria rapid diagnostic test, Malaria Blood smear, Malaria PCR, Anopheles mosquitoes anti-saliva antibodies

MeSH Terms

Conditions

Malaria; Behavior

Condition Hierarchy (Ancestors)

Protozoan Infections; Parasitic Diseases; Infections; Mosquito-Borne Diseases; Vector Borne Diseases

Study Officials

• Carolyn Nabasumba

  Epicentre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 3, 2010
• First Posted: February 4, 2010
• Study Start: January 1, 2010
• Primary Completion: February 1, 2010
• Study Completion: July 1, 2010
• Last Updated: August 12, 2011

Record last verified: 2011-08

Locations

UG (1)