High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

NCT01058161 | Completed

• 2 other identifiers: 2009-A01040-572009 28
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The present project aims at evaluating the diagnostic potential of high-field MRI (3 Teslas) for joint disease. At this field, given that isotropic image resolution of 400 microns can be obtained, one could expect an early detection of joint abnormalities. The additional aim of this project will be to develop a quantitative analyse of the corresponding high-resolution images.

Conditions

Abnormality; Inflammation; Rheumatism

Keywords

wrist and hand cartilage abnormalities in inflammatory and chronic rheumatisms

Outcome Measures

Primary Outcomes (1)

• can be obtained, one could expect an early detection of joint abnormalities

  24 months

Secondary Outcomes (1)

• will be to develop a quantitative analyse of the corresponding high-resolution images.

  24 months

Study Arms (5)

Suspects or affected by rheumatoid polyarthritis

OTHER

Other: high-field MRI (3 Teslas)

stiffening spondylitis with axial and peripheral infringement

OTHER

Other: high-field MRI (3 Teslas)

polyarthralgies with or without arthritis

OTHER

Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis

Other: high-field MRI (3 Teslas)

Healthy control

OTHER

Other: high-field MRI (3 Teslas)

not inflammatory control

OTHER

Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

Other: high-field MRI (3 Teslas)

Interventions

high-field MRI (3 Teslas) OTHER

high-field MRI (3 Teslas)

Healthy control; Suspects or affected by rheumatoid polyarthritis; not inflammatory control; polyarthralgies with or without arthritis; stiffening spondylitis with axial and peripheral infringement

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• gp Suspects or affected by rheumatoid polyarthritis
• Morning articular Stiffness of at least 15 minutes.
• Arthalgias or Arthritises of at least three joints(articulations), among which those of the hand.
• Possible rheumatoid Presence of a factor(mailman) and\\or Antibody anti peptides positive citrullinés.
• Typical possible radiological Hurts on the standard clichés(pictures) of the reached(affected) joints(articulations).
• gp Affected by stiffening spondylitis with axial and peripheral infringement :
• Lumbago and steepness lumbar vertebra inflammatory. 2. Arthralgias and\\or peripheral arthritises 3. Possible presence of an allèle HLA 4. Possible presence of a sacro-illite 5. Absence of the other rheumatic markers
• gp Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis
• gp Healthy control
• gp Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

You may not qualify if:

• Claustrophobia,
• metallic foreign bodies,
• pacemakers The pregnant women,
• parturients or who breast-feed are excluded from the study

Sponsors & Collaborators

• Assistance Publique Hopitaux De Marseille: lead

Study Sites (1)

Assistance Publique Hopitaux de Marseille

Marseille, France

Location

MeSH Terms

Conditions

Congenital Abnormalities; Inflammation; Rheumatic Diseases

Condition Hierarchy (Ancestors)

Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases

Study Officials

• sandrine guis, PU PH

  Assistance Publique Hopitaux De Marseille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 27, 2010
• First Posted: January 28, 2010
• Study Start: December 1, 2009
• Primary Completion: February 1, 2013
• Study Completion: February 1, 2013
• Last Updated: August 28, 2014

Record last verified: 2014-08

Locations

FR (1)