Cognitive Function in Elderly Marathon Runners

NCT01045031 | Unknown Results

• 1 other identifier: Grant Project number 12979
• Study Type: observational
• Target: 114
• Locations: 0 countries
• Sites: N/A

Brief Summary

There is substantial research on the effects of physical exercise on cognitive functions. However, less attention has been paid on the requirements of training intensity and length to enhance cognitive abilities in the elderly. To the investigators knowledge no studies have evaluated the effects of extensive endurance exercise training on cognitive functions by studying elderly marathon runners and bicyclists. On the basis of the scientific literature published so far it is not known whether the beneficial impact of endurance exercise training depends on the intensity of training. The investigators therefore designed a cohort study with adequate power in order to evaluate the effects of intensive endurance exercise training on cognition. This trial, an Austrian prospective cohort study in cognitive function of elderly marathon-runners (APSOEM) is being conducted and will compare neuropsychological performance outcomes of elderly marathon runners or bicyclists with controls matched concerning age, education years, occupation, and verbal intelligence.

Conditions

Cognitive Decline

Keywords

cognitive function, aging, brain-derived neurotrophic factor

Outcome Measures

Primary Outcomes (2)

• the Proportion of Subjects, Who Will Develop Mild Cognitive Impairment

  Hypothesis will be tested at the second follow-up examinations.

  10 years

• Brain-derived Neurotrophic Factor (BDNF)

  Baseline and 5 years

Secondary Outcomes (2)

• Self Rating by Questionnaires

  Baseline and 5 years

• Insulin-like Growth Factor (IGF-1)

  Baseline and 5 years

Study Arms (2)

Controls

Controls were subsequently contacted via personal contact and three additional advertisements (two in an Austrian newspaper ("Krone") and one in an Austrian bicyclist journal ("Bicyclist Sports"). The controls were matched according to age, sex and years of education

marathon athletes

Runners participating in the 2008 Wachau half marathon (21,2 km) and the Vienna City marathon (42,5 km) as well as bicyclists participating at the Corinthian marathon (180km). Inclusion criteria:1) participation in at least one of these 3 marathons in the preceding two years,2)still in continuous training during the recruitment phase (at least 2 hours/week), 3) aged over 60. Exclusion criteria:(a) present or past exposure to neurotoxic substances (b) if they did not speak German as their native language (c) diseases that markedly affect CNS functions (d) manifest cardiovascular disease, (e) chronic alcoholism (daily alcohol intake \> 60 g or diagnosed history of alcoholism) and (f) unwillingness to give informed consent.

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Marathon runners, bicyclists and controls from the greater Vienna area

You may qualify if:

• Current Marathon runners or marathon bicyclists and controls from the greater Vienna area

You may not qualify if:

• Current of past neurotoxic exposure
• Not German as native language
• Diseases, that might affect central nervous system (stroke, meningitis, meningeoma, hydrocephalus,..)
• Manifest cardiovascular disease
• Alcoholism

Sponsors & Collaborators

• Medical University of Vienna: lead
• National Bank of Austria: collaborator

Related Publications (2)

• Mucher P, Batmyagmar D, Perkmann T, Repl M, Radakovics A, Ponocny-Seliger E, Lukas I, Fritzer-Szekeres M, Lehrner J, Knogler T, Tscholakoff D, Fondi M, Wagner OF, Winker R, Haslacher H. Basal myokine levels are associated with quality of life and depressed mood in older adults. Psychophysiology. 2021 May;58(5):e13799. doi: 10.1111/psyp.13799. Epub 2021 Mar 2.

  PMID: 33655551 DERIVED

• Winker R, Lukas I, Perkmann T, Haslacher H, Ponocny E, Lehrner J, Tscholakoff D, Dal-Bianco P. Cognitive function in elderly marathon runners: cross-sectional data from the marathon trial (APSOEM). Wien Klin Wochenschr. 2010 Dec;122(23-24):704-16. doi: 10.1007/s00508-010-1485-z. Epub 2010 Nov 15.

  PMID: 21072603 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Apolipoprotein E4 genotype, Insulin-like growth factor-1, Brain-derived neurotrophic factor, rs6265-Genotype

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Results Point of Contact

• Title: Dr. Robert Winker
• Organization: Health and Prevention Center, Sanatorium Hera, Vienna, Austria

robert.winker@hera.co.at

0043(1)-31350

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Ass. Prof.

Study Record Dates

• First Submitted: January 7, 2010
• First Posted: January 8, 2010
• Study Start: December 1, 2008
• Primary Completion: February 1, 2014
• Study Completion: December 1, 2018
• Last Updated: June 26, 2018
• Results First Posted: July 11, 2016

Record last verified: 2018-03

Data Sharing

• IPD Sharing: Will not share