Evaluating the Impact of Cerebral Ischemic And Degenerative Changes On Cognition

NCT00704327 | Terminated

• 1 other identifier: 2008-029
• Study Type: observational
• Target: 170
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate whether or not cerebral atrophy scores obtained from a brain MRI can correlate with Cognitive Test results. These results hope to demonstrate a link between cerebral ischemic/degenerative changes shown on the MRI and cognition functions results.

Conditions

Cognitive Decline

Keywords

Cognitive Functions; Brain Ischemia; Cerebral Atrophy; Dementia; Intracranial atherosclerosis; Memory impairment

Outcome Measures

Primary Outcomes (1)

• Correlate quantitative measures of cerebral atrophic and ischemic changes with level of cognition using Mental Status Exam and Brain MRI exam

  One time visit, duration of MRI

Secondary Outcomes (1)

• Establish reliable imaging criteria to identify normal age induced changes versus pathologic process comparing Mental Status Exam with Brain MRI(measuring CSF and Brain volumes)

  Duration of study 3 years

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects identified from Neurology Department who have already undergone Cognitive Testing and have been referred for an MRI exam

You may qualify if:

• Subjects older than 50 years of age
• Subjects who have undergone Cognitive Testing
• Subjects who can cooperate and give informed consent

You may not qualify if:

• Subjects with known medical conditions predisposing them for atrophy such as: Chronic renal failure, HIV, head/neck tumors, prior radiation, post- traumatic brain disorder, metabolic disorders of brain, polysubstance abuse, and steroid use

Sponsors & Collaborators

• Lahey Clinic: lead

Study Sites (1)

Lahey Clinic, Inc.

Burlington, Massachusetts, 01805, United States

Location

Related Publications (14)

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  BACKGROUND

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  PMID: 8988189 BACKGROUND

MeSH Terms

Conditions

Cognitive Dysfunction; Brain Ischemia; Dementia; Intracranial Arteriosclerosis; Memory Disorders

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Intracranial Arterial Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Sami H. Erbay, M.D.

  Lahey Clinic, Inc.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 20, 2008
• First Posted: June 24, 2008
• Study Start: February 1, 2008
• Primary Completion: March 1, 2017
• Study Completion: March 1, 2017
• Last Updated: December 21, 2017

Record last verified: 2017-08

Locations

US (1)