A Study With Aleglitazar in Patients With a Recent Acute Coronary Syndrome and Type 2 Diabetes Mellitus
A Safety and Efficacy Study to Evaluate the Potential of Aleglitazar to Reduce Cardiovascular Risk in Coronary Heart Disease (CHD) Patients With a Recent Acute Coronary Syndrome (ACS) Event and Type 2 Diabetes Mellitus (T2D)
2 other identifiers
interventional
7,226
27 countries
810
Brief Summary
This double-blind, parallel, two-arm study will evaluate the potential to reduce cardiovascular risk, the tolerability and long-term safety profile of aleglitazar compared to placebo on top of standard care in patients with recent acute coronary syndrome (ACS) and type 2 diabetes mellitus. Patients will be randomized to receive either aleglitazar or placebo once daily as oral doses. The study will last until at least 950 events occur, but time on study treatment will be for at least 2.5 years.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 diabetes-mellitus-type-2
Started Feb 2010
Longer than P75 for phase_3 diabetes-mellitus-type-2
810 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 5, 2010
CompletedFirst Posted
Study publicly available on registry
January 6, 2010
CompletedStudy Start
First participant enrolled
February 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2013
CompletedNovember 2, 2016
November 1, 2016
3.8 years
January 5, 2010
November 1, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
Effect on cardiovascular death, non-fatal myocardial infarction and non-fatal stroke
Throughout study, approximately 4.5 years
Secondary Outcomes (3)
Effects on other cardiovascular endpoints
Throughout study, approximately 4.5 years
Glycemic control, lipoprotein profile, blood pressure, biomarkers of cardiovascular risk
Throughout study, months 1, 3, 6, 9, 12 and then every 6 months thereafter
Tolerability and long-term safety profile
Throughout study, approximately 4.5 years
Study Arms (2)
Aleglitazar
EXPERIMENTALPlacebo
PLACEBO COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Adults \>18 years of age
- Type 2 diabetes mellitus
- Hospitalization for ACS event and randomization between hospital discharge and 8 weeks after the ACS index event (day of hospitalization)
You may not qualify if:
- Estimated glomerular filtration rate \<45 mL/min/1.73m2
- Concomitant treatment with a thiazolidinedione and/or fibrate
- Triglycerides \>400 mg/dL
- Anaemia
- Symptomatic congestive heart failure classified as New York Heart Association (NYHA) class II-IV (France and Germany: Symptomatic congestive heart failure classified as NYHA class I-IV)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (810)
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Birmingham, Alabama, 35209, United States
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Birmingham, Alabama, 35294, United States
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Mobile, Alabama, 36617, United States
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Mobile, Alabama, 36693, United States
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Mesa, Arizona, 85206, United States
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Phoenix, Arizona, 85023, United States
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Phoenix, Arizona, 85029, United States
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Tucson, Arizona, 85712, United States
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Tucson, Arizona, 85724-5078, United States
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Anaheim, California, 92801, United States
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Banning, California, 92220, United States
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Carmichael, California, 95608, United States
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Fresno, California, 93720, United States
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Fullerton, California, 92835, United States
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Glendale, California, 91204, United States
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Hawaiian Gardens, California, 90716, United States
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Inglewood, California, 90301, United States
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Laguna Hills, California, 92653, United States
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Long Beach, California, 90822, United States
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Los Angeles, California, 90033, United States
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Northridge, California, 91325, United States
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Orange, California, 92868, United States
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Pomona, California, 91767, United States
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Redondo Beach, California, 90277, United States
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Salinas, California, 93901, United States
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San Diego, California, 92103, United States
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San Francisco, California, 94115, United States
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Santa Ana, California, 92704, United States
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Sylmar, California, 91342, United States
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Thousand Oaks, California, 91360, United States
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Torrance, California, 90502, United States
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Ventura, California, 90265, United States
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Colorado Springs, Colorado, 80909, United States
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Denver, Colorado, 80218, United States
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Denver, Colorado, 80220, United States
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Bridgeport, Connecticut, 06606, United States
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Hartford, Connecticut, 06102, United States
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Stamford, Connecticut, 06905, United States
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Seaford, Delaware, 19973, United States
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Aventura, Florida, 33180, United States
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Boynton Beach, Florida, 33472, United States
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Clearwater, Florida, 33756, United States
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Coral Springs, Florida, 33065, United States
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Doral, Florida, 33166, United States
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Edgewater, Florida, 32141, United States
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Elizabeth, Florida, 07202, United States
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Fort Lauderdale, Florida, 33316, United States
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Gainesville, Florida, 32608, United States
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Hialeah, Florida, 33010, United States
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Hollywood, Florida, 33021, United States
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Jacksonville Beach, Florida, 32250, United States
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Melbourne, Florida, 32901, United States
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Miami, Florida, 33136, United States
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Miami, Florida, 33173, United States
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Miramar, Florida, 33025, United States
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Naples, Florida, 34102, United States
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Ocala, Florida, 34471, United States
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Orlando, Florida, 32806, United States
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Panama City, Florida, 32401, United States
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Sarasota, Florida, 34239, United States
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Sarasota, Florida, 34292, United States
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St. Petersburg, Florida, 33701, United States
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St. Petersburg, Florida, 33709, United States
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Tampa, Florida, 33613, United States
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Trinity, Florida, 34652, United States
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Vero Beach, Florida, 32960, United States
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Atlanta, Georgia, 30312, United States
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Decatur, Georgia, 30033, United States
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Macon, Georgia, 31201, United States
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Gurnee, Illinois, 60031, United States
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Elkhart, Indiana, 46514, United States
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Indianapolis, Indiana, 46260, United States
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Lafayette, Indiana, 47905, United States
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Ames, Iowa, 50010, United States
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Council Bluffs, Iowa, 51501, United States
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Davenport, Iowa, 52803, United States
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Des Moines, Iowa, 50314, United States
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Elizabethtown, Kentucky, 42701, United States
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Owensboro, Kentucky, 42303, United States
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Alexandria, Louisiana, 71301, United States
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Convington, Louisiana, 70433, United States
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Hammond, Louisiana, 70403, United States
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Houma, Louisiana, 70360, United States
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Lafayette, Louisiana, 70508, United States
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Laplace, Louisiana, 70068, United States
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Metarie, Louisiana, 70002, United States
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New Orleans, Louisiana, 70112, United States
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New Orleans, Louisiana, 70121, United States
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Opelousas, Louisiana, 70570, United States
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Shreveport, Louisiana, 71101, United States
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Shreveport, Louisiana, 71105, United States
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Slidell, Louisiana, 70458, United States
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Zachary, Louisiana, 70791, United States
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Bangor, Maine, 04401, United States
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Annapolis, Maryland, 21401, United States
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Baltimore, Maryland, 21201, United States
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Baltimore, Maryland, 21236, United States
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Columbia, Maryland, 21044, United States
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Oxon Hill, Maryland, 20745, United States
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Salisbury, Maryland, 21801, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02215, United States
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Fall River, Massachusetts, 02720, United States
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Hyannis, Massachusetts, 02601, United States
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Worcester, Massachusetts, 01604, United States
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Alpena, Michigan, 49707, United States
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Ann Arbor, Michigan, 48106, United States
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Bay City, Michigan, 48708, United States
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Flint, Michigan, 48423, United States
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Kalamazoo, Michigan, 49048, United States
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Lansing, Michigan, 48910, United States
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Petoskey, Michigan, 49770, United States
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Royal Oak, Michigan, 48073, United States
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Saginaw, Michigan, 48602, United States
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Saginaw, Michigan, 48604, United States
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Minneapolis, Minnesota, 55407, United States
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Minneapolis, Minnesota, 55415, United States
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Minneapolis, Minnesota, 55417, United States
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Rochester, Minnesota, 55905, United States
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Saint Cloud, Minnesota, 56362, United States
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Saint Paul, Minnesota, 55102, United States
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Jackson, Mississippi, 39216, United States
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Picayune, Mississippi, 39466, United States
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Chesterfield, Missouri, 63017, United States
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Washington, Missouri, 63090, United States
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Great Falls, Montana, 59405, United States
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Freemont, Nebraska, 68025, United States
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Omaha, Nebraska, 68114, United States
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Omaha, Nebraska, 68131, United States
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Las Vegas, Nevada, 89102, United States
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Bridgewater, New Jersey, 08807, United States
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Mine Hill, New Jersey, 07803, United States
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Newark, New Jersey, 07103, United States
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Somerset, New Jersey, 08873, United States
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Albuquerque, New Mexico, 87102, United States
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Albuquerque, New Mexico, 87131, United States
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Albany, New York, 12206-1098, United States
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Albany, New York, 12211, United States
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Brooklyn, New York, 11215, United States
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Buffalo, New York, 14215, United States
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New York, New York, 10021, United States
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New York, New York, 10025, United States
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New York, New York, 10029, United States
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New York, New York, 10032, United States
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Suffern, New York, 10901, United States
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Syracuse, New York, 13210, United States
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The Bronx, New York, 10469, United States
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Troy, New York, 12180, United States
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Charlotte, North Carolina, 28204, United States
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Durham, North Carolina, 27704, United States
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Durham, North Carolina, 27710, United States
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Greenville, North Carolina, 27834, United States
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Rocky Mount, North Carolina, 27804, United States
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Winston-Salem, North Carolina, 27103, United States
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Canton, Ohio, 44708, United States
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Cincinnati, Ohio, 45219, United States
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Cincinnati, Ohio, 45224, United States
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Cleveland, Ohio, 44106, United States
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Columbus, Ohio, 43201, United States
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Columbus, Ohio, 43221, United States
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Dayton, Ohio, 45428, United States
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Kettering, Ohio, 45429, United States
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Marion, Ohio, 43302, United States
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Middleburg Heights, Ohio, 44130, United States
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Springfield, Ohio, 45505, United States
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Toledo, Ohio, 43608, United States
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Oklahoma City, Oklahoma, 73103, United States
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Tulsa, Oklahoma, 74104, United States
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Portland, Oregon, 97239, United States
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Chambersburg, Pennsylvania, 17201, United States
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Danville, Pennsylvania, 17822, United States
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Harrisburg, Pennsylvania, 17112, United States
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Natrona Heights, Pennsylvania, 15065, United States
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Philadelphia, Pennsylvania, 19106, United States
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Philadelphia, Pennsylvania, 19107, United States
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Philadelphia, Pennsylvania, 19140, United States
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Pottstown, Pennsylvania, 19464, United States
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Upper Darby, Pennsylvania, 19082, United States
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Pawtucket, Rhode Island, 02860, United States
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Providence, Rhode Island, 02903, United States
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Providence, Rhode Island, 02906, United States
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Greer, South Carolina, 29651, United States
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Johnson City, Tennessee, 37604, United States
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Kingsport, Tennessee, 37660, United States
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Lexington, Tennessee, 38351, United States
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Nashville, Tennessee, 37203, United States
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Tullahoma, Tennessee, 37388, United States
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Amarillo, Texas, 79106, United States
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Austin, Texas, 78705, United States
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Bellaire, Texas, 77401, United States
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Dallas, Texas, 75216, United States
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Dallas, Texas, 75230, United States
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Dallas, Texas, 75231, United States
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Dallas, Texas, 75390-9063, United States
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Grapevine, Texas, 76051, United States
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Houston, Texas, 77002, United States
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Houston, Texas, 77024, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77075, United States
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Houston, Texas, 77090, United States
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Kerrville, Texas, 78028, United States
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Kingwood, Texas, 77339, United States
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Lubbock, Texas, 79410, United States
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Odessa, Texas, 79761, United States
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Plano, Texas, 75024, United States
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San Antonio, Texas, 78205, United States
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San Antonio, Texas, 78229, United States
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San Antonio, Texas, 78258, United States
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Tomball, Texas, 77375, United States
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Victoria, Texas, 77901, United States
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Layton, Utah, 84041, United States
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Murray, Utah, 84157, United States
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Danville, Virginia, 24541, United States
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Roanoke, Virginia, 24104, United States
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Huntington, West Virginia, 25701, United States
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Beloit, Wisconsin, 53511, United States
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Burlington, Wisconsin, 53105, United States
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Green Bay, Wisconsin, 54301, United States
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La Crosse, Wisconsin, 54601-4795, United States
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Milwaukee, Wisconsin, 53215, United States
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Milwaukee, Wisconsin, 53295, United States
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Buenos Aires, 1425DES, Argentina
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Buenos Aires, 1428, Argentina
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Buenos Aires, C1155ADP, Argentina
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Buenos Aires, c1181ach, Argentina
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Buenos Aires, C1425AGC, Argentina
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Buenos Aires, C1426AGU, Argentina
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Buenos Aires, C1437BZL, Argentina
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Caba, C1119ACN, Argentina
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Caba, C1405BCK, Argentina
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Caba, C1428DCO, Argentina
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Capital Federal, 1180, Argentina
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Ciudad Autonoma Bs As, C1280AEB, Argentina
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Coronel Suárez, B7540GDH, Argentina
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Corrientes, W3400AMZ, Argentina
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Córdoba, 5000, Argentina
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Córdoba, 5009, Argentina
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Córdoba, X5000EPU, Argentina
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Haedo, B1706AJU, Argentina
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Mendoza, 5500, Argentina
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Morón, 1708, Argentina
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Rosario, 2000, Argentina
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Rosario, S2000DIF, Argentina
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Rosario, S2002OUR, Argentina
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Salta, 4400, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Santa Fe, 3000, Argentina
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Santiago del Estero, G4200AQK, Argentina
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Zárate, 2800, Argentina
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Garran, Australian Capital Territory, 2605, Australia
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Bankstown, New South Wales, 2200, Australia
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Concord, New South Wales, 2139, Australia
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Darlinghurst, New South Wales, 2010, Australia
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Liverpool BC, New South Wales, 1871, Australia
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New Lambton, New South Wales, 2305, Australia
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Penrith, New South Wales, 2751, Australia
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St Leonards, New South Wales, 2065, Australia
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Sydney, New South Wales, 2217, Australia
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Wollongong, New South Wales, 2500, Australia
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Douglas, Queensland, 4184, Australia
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Milton, Queensland, 4064, Australia
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Redcliffe, Queensland, 4020, Australia
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Southport, Queensland, 4215, Australia
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Woolloongabba, Queensland, 4102, Australia
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Adelaide, South Australia, 5000, Australia
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Elizabeth Vale, South Australia, 5112, Australia
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Woodville, South Australia, 5011, Australia
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Ballarat, Victoria, 3353, Australia
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Geelong, Victoria, 3220, Australia
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Richmond, Victoria, 3121, Australia
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Shepparton, Victoria, 3630, Australia
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Fortaleza, Ceará, 60115282, Brazil
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Fortaleza, Ceará, 60430-370, Brazil
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Fortaleza, Ceará, 60430970, Brazil
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Fortaleza, Ceará, 60840285, Brazil
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Cariacica, Espírito Santo, 29151920, Brazil
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Salvador, Estado de Bahia, 40010020, Brazil
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Brasília, Federal District, 71625-009, Brazil
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Goiânia, Goiás, 74823-470, Brazil
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Campo Grande, Mato Grosso do Sul, 79070900, Brazil
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Belo Horizonte, Minas Gerais, 30110-068, Brazil
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Belo Horizonte, Minas Gerais, 30150-221, Brazil
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Belo Horizonte, Minas Gerais, 30150-240, Brazil
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Uberlândia, Minas Gerais, 38400-368, Brazil
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Campina Grande do Sul, Paraná, 83430-000, Brazil
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Curitiba, Paraná, 80220-000, Brazil
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Curitiba, Paraná, 80320-320, Brazil
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Curitiba, Paraná, 80730-150, Brazil
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Recife, Pernambuco, 50100-060, Brazil
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Rio de Janeiro, Rio de Janeiro, 22240-006, Brazil
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Rio de Janeiro, Rio de Janeiro, 22271-100, Brazil
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Natal, Rio Grande do Norte, 59020-100, Brazil
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Passo Fundo, Rio Grande do Sul, 99010-080, Brazil
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Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
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Porto Alegre, Rio Grande do Sul, 90035-003, Brazil
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Porto Alegre, Rio Grande do Sul, 90035-170, Brazil
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Porto Alegre, Rio Grande do Sul, 90110-270, Brazil
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Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
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Porto Alegre, Rio Grande do Sul, 90620-001, Brazil
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Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
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Sao Jose Do Rio Preto, Santa Catarina, 15015-210, Brazil
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São José, Santa Catarina, 88103-460, Brazil
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Campinas, São Paulo, 13024-011, Brazil
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Campinas, São Paulo, 13060-803, Brazil
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São José do Rio Preto, São Paulo, 15090-000, Brazil
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São Paulo, São Paulo, 01244-030, Brazil
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São Paulo, São Paulo, 05403-000, Brazil
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São Paulo, São Paulo, 1506000, Brazil
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Edmonton, Alberta, T5H 3V9, Canada
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Edmonton, Alberta, T6G1Z1, Canada
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Edmonton, Alberta, T6K 4C1, Canada
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Red Deer, Alberta, T4N 6R2, Canada
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New Westminster, British Columbia, V3L 3W4, Canada
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Surrey, British Columbia, V3V 1Z2, Canada
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Bathurst, New Brunswick, E2A 1A9, Canada
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Moncton, New Brunswick, E1G 1A7, Canada
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Moncton, New Brunswick, E1L 2Z3, Canada
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Saint John, New Brunswick, E2L 4L2, Canada
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St. John's, Newfoundland and Labrador, A1E2C2, Canada
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Bridgewater, Nova Scotia, B4V 3N2, Canada
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Halifax, Nova Scotia, B3H 2Y9, Canada
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Brampton, Ontario, L6W2X7, Canada
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Brampton, Ontario, L6Z 4N5, Canada
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Burlington, Ontario, L7M 4Y1, Canada
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Burlington, Ontario, L7R4EZ, Canada
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Cambridge, Ontario, N1R 6V6, Canada
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Cambridge, Ontario, N1R 7R1, Canada
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Fort Eire, Ontario, L2A1Z3, Canada
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Greater Sudbury, Ontario, P3C 5K7, Canada
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Greater Sudbury, Ontario, P3E 3B8, Canada
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Greater Sudbury, Ontario, P3E 5J1, Canada
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Hamilton, Ontario, L8L 2X2, Canada
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Kingston, Ontario, K7L 5G2, Canada
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Kitchener, Ontario, N2M 1B2, Canada
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London, Ontario, N6A 4L6, Canada
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London, Ontario, N6C 5J1, Canada
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Mississauga, Ontario, L4T2J2, Canada
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Mississauga, Ontario, L5B 2P7, Canada
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Newmarket, Ontario, L3Y 8C3, Canada
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Oshawa, Ontario, L1H 1B9, Canada
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Smiths Falls, Ontario, K7A 4W8, Canada
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Thunder Bay, Ontario, P7B 6V4, Canada
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Toronto, Ontario, M5B 1W8, Canada
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Charlottetown, Prince Edward Island, C1A 8T5, Canada
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Chicoutimi, Quebec, G7H 5H6, Canada
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Chicoutimi, Quebec, G7H 7Y8, Canada
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Gatineau, Quebec, J8Y 6S9, Canada
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Granby, Quebec, J2G 1T7, Canada
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Granby, Quebec, J2G 8Z9, Canada
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Laval, Quebec, H7M 3L9, Canada
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Lévis, Quebec, G6V 4Z5, Canada
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Longueuil, Quebec, J4M 2X1, Canada
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Montreal, Quebec, H1T 1C8, Canada
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Montreal, Quebec, H2K 4L5, Canada
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Montreal, Quebec, H3G 1A4, Canada
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Montreal, Quebec, H4J 1C5, Canada
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Québec, Quebec, G1G 3Z4, Canada
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Québec, Quebec, G1N 4V3, Canada
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Saint-Charles-Borromée, Quebec, J6E 6J2, Canada
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Saint-Jérôme, Quebec, J7Z 5T3, Canada
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Saint-Lambert, Quebec, J4P 2H4, Canada
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Saint-Laurent, Quebec, H4T 1Z9, Canada
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Saint-Léonard, Quebec, H1S 3A9, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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Sherbrooke, Quebec, J1J 2E3, Canada
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Ste. Foy, Quebec, G1V 4G5, Canada
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Terrebonne, Quebec, J6V 2H2, Canada
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Trois-Rivières, Quebec, G8Z 3R9, Canada
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Val DOr, Quebec, J9P 3Y1, Canada
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Vaudreuil-Dorion, Quebec, J7V 8P9, Canada
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Baotou, 014040, China
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Beijing, 100020, China
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Beijing, 100029, China
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Beijing, 100038, China
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Beijing, 100050, China
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Beijing, 100088, China
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Beijing, 100101, China
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Beijing, 10029, China
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Beijing, 100730, China
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Beijing, 100853, China
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Beijng, 100700, China
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Changsha, 410007, China
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Changsha, 410011, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Dalian, 116011, China
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Daqing, 163001, China
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Guangzhou, 510030, China
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Guangzhou, 510080, China
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Hangzhou, 310003, China
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Hangzhou, 310013, China
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Hangzhou, 310016, China
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Jinan, 250012, China
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Nanjing, 210009, China
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Nanning, 530021, China
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Qingdao, 266011, China
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Shanghai, 200001, China
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Shanghai, 200011, China
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Shanghai, 200030, China
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Shanghai, 200031, China
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Shanghai, 200040, China
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Shanghai, 200065, China
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Shanghai, 200072, China
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Shanghai, 200233, China
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Shenyang, 110004, China
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Shenyang, 110016, China
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Shijiazhuang, 050082, China
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Tianjin, 300014, China
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Wuhan, 430071, China
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Xi'an, 710061, China
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Brno, 625 00, Czechia
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Brno, CA-656 91, Czechia
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Hradec Králové, 50005, Czechia
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Jindřichův Hradec, 37701, Czechia
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Kladno, 27259, Czechia
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Olomouc, 77520, Czechia
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Prague, 128 00, Czechia
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Prague, 128 08, Czechia
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Prague, 14021, Czechia
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Tábor, 390 03, Czechia
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Teplice, 41529, Czechia
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Trutnov, 541 01, Czechia
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Znojmo, 669 02, Czechia
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Aalborg, 9000, Denmark
Unknown Facility
Copenhagen, Denmark
Unknown Facility
Fredericia, 7000, Denmark
Unknown Facility
Herning, 7400, Denmark
Unknown Facility
Odense, 5000 C, Denmark
Unknown Facility
Slagelse, 4200, Denmark
Unknown Facility
Albi, 81000, France
Unknown Facility
Besançon, 25000, France
Unknown Facility
Bron, 69677, France
Unknown Facility
Cambrai, 59407, France
Unknown Facility
Créteil, 94010, France
Unknown Facility
Dijon, 21079, France
Unknown Facility
Lagny-sur-Marne, 77405, France
Unknown Facility
Le Coudray, 28630, France
Unknown Facility
Le Plessis-Robinson, 92350, France
Unknown Facility
Marseille, 13285, France
Unknown Facility
Montfermeil, 93370, France
Unknown Facility
Montpellier, 34295, France
Unknown Facility
Paris, 75651, France
Unknown Facility
Paris, 75908, France
Unknown Facility
Pessac, 3600, France
Unknown Facility
Saint-Herblain, 44800, France
Unknown Facility
Valenciennes, 59322, France
Unknown Facility
Bad Krozingen, 79189, Germany
Unknown Facility
Bad Nauheim, 61231, Germany
Unknown Facility
Bad Oeynhausen, 32545, Germany
Unknown Facility
Bad Rothenfelde, 49124, Germany
Unknown Facility
Berlin, 12203, Germany
Unknown Facility
Berlin, 12559, Germany
Unknown Facility
Berlin, 13187, Germany
Unknown Facility
Berlin, 13353, Germany
Unknown Facility
Berlin, 14050, Germany
Unknown Facility
Bernried, 82347, Germany
Unknown Facility
Bochum, 44789, Germany
Unknown Facility
Bonn, 53127, Germany
Unknown Facility
Brandenburg, 14770, Germany
Unknown Facility
Burg, 03096, Germany
Unknown Facility
Cologne, 50923, Germany
Unknown Facility
Dortmund, 44137, Germany
Unknown Facility
Düsseldorf, 40225, Germany
Unknown Facility
Essen, 45122, Germany
Unknown Facility
Frankfurt, 65929, Germany
Unknown Facility
Fulda, 36043, Germany
Unknown Facility
Fürth, 90766, Germany
Unknown Facility
Halle, 06120, Germany
Unknown Facility
Hamburg, 20099, Germany
Unknown Facility
Hanover, 30167, Germany
Unknown Facility
Heidelberg, 69126, Germany
Unknown Facility
Homburg/Saar, 66424, Germany
Unknown Facility
Kiel, 24105, Germany
Unknown Facility
Lahr, 77933, Germany
Unknown Facility
Langen, 63225, Germany
Unknown Facility
Mainz, 55131, Germany
Unknown Facility
Mannheim, 68167, Germany
Unknown Facility
Mönchengladbach, 41063, Germany
Unknown Facility
München, 80336, Germany
Unknown Facility
Münster, 48149, Germany
Unknown Facility
Nienburg, 31582, Germany
Unknown Facility
Pirna, 01796, Germany
Unknown Facility
Regensburg, 93053, Germany
Unknown Facility
Rotenburg (Wümme), 36199, Germany
Unknown Facility
Rüdersdorf, 15562, Germany
Unknown Facility
Wuppertal, 42117, Germany
Unknown Facility
Toulouse, 31059, Grenada
Unknown Facility
Balatonfüred, 8230, Hungary
Unknown Facility
Budapest, 1032, Hungary
Unknown Facility
Budapest, 1085, Hungary
Unknown Facility
Budapest, 1088, Hungary
Unknown Facility
Budapest, 1096, Hungary
Unknown Facility
Budapest, 1097, Hungary
Unknown Facility
Budapest, 1115, Hungary
Unknown Facility
Debrecen, 4032, Hungary
Unknown Facility
Gyula, 5700, Hungary
Unknown Facility
Kaposvár, 7400, Hungary
Unknown Facility
Kecskemét, 6000, Hungary
Unknown Facility
Miskolc, 3526, Hungary
Unknown Facility
Pécs, 7643, Hungary
Unknown Facility
Székeshehérvár, 8000, Hungary
Unknown Facility
Szolnok, 5004, Hungary
Unknown Facility
Szombathely, 9700, Hungary
Unknown Facility
Zalaegerszeg, 8900, Hungary
Unknown Facility
Kochi, Kerala, 682304, India
Unknown Facility
Pune, Maharashtra, 411011, India
Unknown Facility
Ahmedabad, 380005, India
Unknown Facility
Ahmedabad, 380014, India
Unknown Facility
Ahmedabad, 380015, India
Unknown Facility
Ahmedabad, 380051, India
Unknown Facility
Bangalore, 560038, India
Unknown Facility
Bangalore, 560060, India
Unknown Facility
Bangalore, 560099, India
Unknown Facility
Banglore, 560034, India
Unknown Facility
Belagavi, 590001, India
Unknown Facility
Belagavi, 590010, India
Unknown Facility
Chennai, 600100, India
Unknown Facility
Gūrgaon, 122001, India
Unknown Facility
Hyderabad, 500001, India
Unknown Facility
Hyderabad, 500004, India
Unknown Facility
Hyderabad, 500024, India
Unknown Facility
Hyderabad, 500034, India
Unknown Facility
Hyderabad, 500063, India
Unknown Facility
Indore, 452001, India
Unknown Facility
Jaipur, 302004, India
Unknown Facility
Kochi, 682041, India
Unknown Facility
Kolkata, 700020, India
Unknown Facility
Lucknow, 226014, India
Unknown Facility
Madurai, 625107, India
Unknown Facility
Mangalore, 575 002, India
Unknown Facility
Mangalore, 575001, India
Unknown Facility
Mangalore, 575002, India
Unknown Facility
Mumbai, 400012, India
Unknown Facility
Mumbai, 400051, India
Unknown Facility
Mysore, 570004, India
Unknown Facility
Nagpur, 440008, India
Unknown Facility
Nagpur, 440010, India
Unknown Facility
New Delhi, 110060, India
Unknown Facility
Palakkad, 678013, India
Unknown Facility
Pune, 411 001, India
Unknown Facility
Pune, 411004, India
Unknown Facility
Pune, 411030, India
Unknown Facility
Secunderabad, 500003, India
Unknown Facility
Trivandeum, 695011, India
Unknown Facility
Ballinasloe, Ireland
Unknown Facility
Dublin, 7, Ireland
Unknown Facility
Dublin, 8, Ireland
Unknown Facility
Dublin, 9, Ireland
Unknown Facility
Galway, Ireland
Unknown Facility
Tallaght Dublin, D24, Ireland
Unknown Facility
Napoli, Campania, 80131, Italy
Unknown Facility
Pozzuoli, Campania, 80078, Italy
Unknown Facility
Bentivoglio, Emilia-Romagna, 40010, Italy
Unknown Facility
Ferrara, Emilia-Romagna, 44100, Italy
Unknown Facility
Reggio Emilia, Emilia-Romagna, 42123, Italy
Unknown Facility
Udine, Friuli Venezia Giulia, 33100, Italy
Unknown Facility
Rome, Lazio, 00189, Italy
Unknown Facility
Bergamo, Lombardy, 24128, Italy
Unknown Facility
Legnano, Lombardy, 20025, Italy
Unknown Facility
Mantova, Lombardy, 46100, Italy
Unknown Facility
Milan, Lombardy, 20138, Italy
Unknown Facility
Milan, Lombardy, 20162, Italy
Unknown Facility
Pavia, Lombardy, 27100, Italy
Unknown Facility
Perugia, Umbria, 06100, Italy
Unknown Facility
Cittadella, Veneto, 35013, Italy
Unknown Facility
Rovigo, Veneto, 45100, Italy
Unknown Facility
Sarawak, Sarawak, 93586, Malaysia
Unknown Facility
George Town, 10990, Malaysia
Unknown Facility
Kelantan, 16150, Malaysia
Unknown Facility
Kota Bharu, 15586, Malaysia
Unknown Facility
Kuala Lumpur, 50400, Malaysia
Unknown Facility
Kuala Lumpur, 59100, Malaysia
Unknown Facility
Kuantan, 25100, Malaysia
Unknown Facility
Serdang, 43000, Malaysia
Unknown Facility
Acapulco, 39670, Mexico
Unknown Facility
Aguascalientes, 20127, Mexico
Unknown Facility
Aguascalientes, 20230, Mexico
Unknown Facility
Chihuahua City, 31000, Mexico
Unknown Facility
Chihuahua City, 31217, Mexico
Unknown Facility
Ciudad Juárez, 32420, Mexico
Unknown Facility
Cuernavaca, 62250, Mexico
Unknown Facility
Culiacán, 80020, Mexico
Unknown Facility
Durango, 34000, Mexico
Unknown Facility
Durango, 34080, Mexico
Unknown Facility
Guadalajara, 44210, Mexico
Unknown Facility
Guadalajara, 44600, Mexico
Unknown Facility
Guadalajara, 44650, Mexico
Unknown Facility
Mexico City, 10700, Mexico
Unknown Facility
Mexico City, 11650, Mexico
Unknown Facility
Mexico City, 14000, Mexico
Unknown Facility
Mexico City, 14050, Mexico
Unknown Facility
Mexico City, 14080, Mexico
Unknown Facility
Monterrey, 64060, Mexico
Unknown Facility
Monterrey, 64460, Mexico
Unknown Facility
Monterrey, 64640, Mexico
Unknown Facility
Monterrey, 64710, Mexico
Unknown Facility
Pachuca, 42000, Mexico
Unknown Facility
Puebla City, 72490, Mexico
Unknown Facility
Puerto Vallarta, 48328, Mexico
Unknown Facility
Querétaro, 76000, Mexico
Unknown Facility
San Luis Potosi S.l.p., 78240, Mexico
Unknown Facility
Tampico, 89000, Mexico
Unknown Facility
Tijuana, 22010, Mexico
Unknown Facility
Tlalnepantla, 54055, Mexico
Unknown Facility
Veracruz, 91700, Mexico
Unknown Facility
Xalapa, 91020, Mexico
Unknown Facility
Zapopan, 45200, Mexico
Unknown Facility
AC Amsterdam, 1091, Netherlands
Unknown Facility
Amstelveen, 1186 AH, Netherlands
Unknown Facility
Amsterdam, 1066 EC, Netherlands
Unknown Facility
Amsterdam, 1105 AZ, Netherlands
Unknown Facility
Hoorn, 1625 HV, Netherlands
Unknown Facility
Leiden, 2333 ZA, Netherlands
Unknown Facility
Maastricht, 6202 AZ, Netherlands
Unknown Facility
Nieuwegein, 3435 CM, Netherlands
Unknown Facility
Nijmegen, 6500 HB, Netherlands
Unknown Facility
Purmerend, 1441 RN, Netherlands
Unknown Facility
Tilburg, 5042 AD, Netherlands
Unknown Facility
Weert, 6001 BE, Netherlands
Unknown Facility
Zaandam, 1502 DV, Netherlands
Unknown Facility
Zwolle, 8011 JW, Netherlands
Unknown Facility
Auckland, New Zealand
Unknown Facility
Christchurch, 8140, New Zealand
Unknown Facility
Hamiton, 3240, New Zealand
Unknown Facility
Lower Hutt, 5040, New Zealand
Unknown Facility
Nelson, 7001, New Zealand
Unknown Facility
Palmerston North, 4410, New Zealand
Unknown Facility
Tauranga, 3112, New Zealand
Unknown Facility
Bêdzin, 42-500, Poland
Unknown Facility
Bialystok, 15-276, Poland
Unknown Facility
Bielsko-Biala, 43-316, Poland
Unknown Facility
Bydgoszcz, 85-826, Poland
Unknown Facility
Bydgoszcz, 85-863, Poland
Unknown Facility
Bytom, 41-902, Poland
Unknown Facility
Gdansk, 80-126, Poland
Unknown Facility
Gdansk, 80-952, Poland
Unknown Facility
Gdynia, 81-402, Poland
Unknown Facility
Gdynia, 81-423, Poland
Unknown Facility
Gdynia, 81-472, Poland
Unknown Facility
Gdynia, 81-519, Poland
Unknown Facility
Gorlice, 38-300, Poland
Unknown Facility
Grodzisk Mazowiecki, 05-754, Poland
Unknown Facility
Katowice, 40-005, Poland
Unknown Facility
Kędzierzyn-Koźle, 47-200, Poland
Unknown Facility
Kielce, 25-315, Poland
Unknown Facility
Krakow, 30-082, Poland
Unknown Facility
Krakow, 30-092, Poland
Unknown Facility
Krakow, 31-202, Poland
Unknown Facility
Krakow, 31-351, Poland
Unknown Facility
Kutno, 99-300, Poland
Unknown Facility
Libiąż, 32-590, Poland
Unknown Facility
Lodz, 91-302, Poland
Unknown Facility
Lodz, 91-490, Poland
Unknown Facility
Lublin, 20-059, Poland
Unknown Facility
Lublin, 20-834, Poland
Unknown Facility
Nowa Sól, 67-100, Poland
Unknown Facility
Nysa, 48-303, Poland
Unknown Facility
Olesnica, Spalice, 56-400, Poland
Unknown Facility
Olsztyn, 10-561, Poland
Unknown Facility
Oława, 55-200, Poland
Unknown Facility
Poznan, 61-848, Poland
Unknown Facility
Puławy, 24-100, Poland
Unknown Facility
Radom, 26-600, Poland
Unknown Facility
Rzeszów, 35301, Poland
Unknown Facility
Swidnica, 58-100, Poland
Unknown Facility
Tarnów, 33-100, Poland
Unknown Facility
Torun, 87-100, Poland
Unknown Facility
Ustroń, 43-450, Poland
Unknown Facility
Ustroñ, 43-450, Poland
Unknown Facility
Warsaw, 02-097, Poland
Unknown Facility
Warsaw, 02-637, Poland
Unknown Facility
Warsaw, 03-242, Poland
Unknown Facility
Warsaw, 03-599, Poland
Unknown Facility
Warsaw, 04-141, Poland
Unknown Facility
Wola, 43-225, Poland
Unknown Facility
Wroclaw, 50-981, Poland
Unknown Facility
Zamość, 22-400, Poland
Unknown Facility
Zgorzelec, 59-900, Poland
Unknown Facility
Żarów, 58-130, Poland
Unknown Facility
£ódx, 91-347, Poland
Unknown Facility
Brasov, 500360, Romania
Unknown Facility
Bucharest, 010628, Romania
Unknown Facility
Bucharest, 020992, Romania
Unknown Facility
Buzău, 120203, Romania
Unknown Facility
Cluj-Napoca, 400006, Romania
Unknown Facility
Craiova, 200147, Romania
Unknown Facility
Galati, 800371, Romania
Unknown Facility
Oradea, 410169, Romania
Unknown Facility
Ploieşti, 100163, Romania
Unknown Facility
Târgu Mureş, 540124, Romania
Unknown Facility
Timișoara, 300310, Romania
Unknown Facility
Moscow, 111539, Russia
Unknown Facility
Saint Petersburg, 193312, Russia
Unknown Facility
Saint Petersburg, 194291, Russia
Unknown Facility
Saint Petersburg, 197341, Russia
Unknown Facility
Busan, 47392, South Korea
Unknown Facility
Busan, 49267, South Korea
Unknown Facility
Busan, 602-739, South Korea
Unknown Facility
Daegu, 41931, South Korea
Unknown Facility
Daegu, 705-717, South Korea
Unknown Facility
Daejeon, 35015, South Korea
Unknown Facility
Gwangju, 61469, South Korea
Unknown Facility
Gyeonggi-do, 10380, South Korea
Unknown Facility
Gyeonggi-do, 14647, South Korea
Unknown Facility
Gyeonggi-do, 431-070, South Korea
Unknown Facility
Gyeonggi-do, 443-380, South Korea
Unknown Facility
Incheon, 400-711, South Korea
Unknown Facility
Incheon, 405-760, South Korea
Unknown Facility
Jeollabuk-do, 561-712, South Korea
Unknown Facility
Kyonggi-do, 411-719, South Korea
Unknown Facility
Seoul, 03080, South Korea
Unknown Facility
Seoul, 06973, South Korea
Unknown Facility
Seoul, 130-702, South Korea
Unknown Facility
Seoul, 136-705, South Korea
Unknown Facility
Seoul, 140-743, South Korea
Unknown Facility
Seoul, 150-950, South Korea
Unknown Facility
Seoul, 152-703, South Korea
Unknown Facility
Seoul, 156-707, South Korea
Unknown Facility
Suwon, 442-723, South Korea
Unknown Facility
Uijongbu, 480-130, South Korea
Unknown Facility
Ulsan, 44033, South Korea
Unknown Facility
Wŏnju, 220-701, South Korea
Unknown Facility
Vitoria-Gasteiz, Alava, 01009, Spain
Unknown Facility
Alicante, Alicante, 03010, Spain
Unknown Facility
Torrevieja, Alicante, 03186, Spain
Unknown Facility
Almería, Almeria, 04009, Spain
Unknown Facility
Barcelona, Barcelona, 08003, Spain
Unknown Facility
Barcelona, Barcelona, 08025, Spain
Unknown Facility
Barcelona, Barcelona, 08035, Spain
Unknown Facility
Granollers, Barcelona, 08400, Spain
Unknown Facility
L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Unknown Facility
Sabadell, Barcelona, 08208, Spain
Unknown Facility
Terrassa, Barcelona, 08227, Spain
Unknown Facility
Jerez de la Frontera, Cadiz, 11402, Spain
Unknown Facility
Figueres, Girona, 17600, Spain
Unknown Facility
Guadalajara, Guadalajara, 19002, Spain
Unknown Facility
A Coruña, La Coruña, 15006, Spain
Unknown Facility
Ferrol, La Coruña, 15405, Spain
Unknown Facility
Santiago de Compostela, La Coruña, 15706, Spain
Unknown Facility
Lugo, Lugo, 27004, Spain
Unknown Facility
Alcorcón, Madrid, 28922, Spain
Unknown Facility
Madrid, Madrid, 28007, Spain
Unknown Facility
Madrid, Madrid, 28040, Spain
Unknown Facility
Madrid, Madrid, 28041, Spain
Unknown Facility
San Sebastián de los Reyes, Madrid, 28702, Spain
Unknown Facility
Málaga, Malaga, 29010, Spain
Unknown Facility
Murcia, Murcia, 30008, Spain
Unknown Facility
Oviedo, Principality of Asturias, 33006, Spain
Unknown Facility
Salamanca, Salamanca, 37007, Spain
Unknown Facility
Seville, Sevilla, 41071, Spain
Unknown Facility
Reus, Tarragona, 43201, Spain
Unknown Facility
Tarragona, Tarragona, 43007, Spain
Unknown Facility
Valencia, Valencia, 46014, Spain
Unknown Facility
Valencia, Valencia, 46017, Spain
Unknown Facility
Bilbao, Vizcaya, 48013, Spain
Unknown Facility
Danderyd Stockholm, SE-182 88, Sweden
Unknown Facility
Gothenburg, 413 45, Sweden
Unknown Facility
Halmstad, 301 85, Sweden
Unknown Facility
Kalmar, 391 85, Sweden
Unknown Facility
Karlstad, 65185, Sweden
Unknown Facility
Kristianstad, 29185, Sweden
Unknown Facility
Malmo, 20502, Sweden
Unknown Facility
Östersund, 83 183, Sweden
Unknown Facility
Skellefteå, 0910-77, Sweden
Unknown Facility
Skövde, 541 85, Sweden
Unknown Facility
Stockholm, 11883, Sweden
Unknown Facility
Stockholm, 17176, Sweden
Unknown Facility
Amphur Mae-Rim, 50180, Thailand
Unknown Facility
Amphur Muang, 57000, Thailand
Unknown Facility
Amphur Muang, 65000, Thailand
Unknown Facility
Bangkok, 10300, Thailand
Unknown Facility
Bangkok, 10330, Thailand
Unknown Facility
Bangkok, 10400, Thailand
Unknown Facility
Bangkok, 10700, Thailand
Unknown Facility
Changwat Sara Buri, 18000, Thailand
Unknown Facility
Chiang Mai, 50200, Thailand
Unknown Facility
Chon Buri, 20000, Thailand
Unknown Facility
Khon Kaen, 40002, Thailand
Unknown Facility
Khonkaen, 40000, Thailand
Unknown Facility
Klong Luang, 12120, Thailand
Unknown Facility
Phitsanulok, 65000, Thailand
Unknown Facility
Abano Terme, 35031, United Kingdom
Unknown Facility
Antrim, BT41 2RL, United Kingdom
Unknown Facility
Ayr, KA6 6DX, United Kingdom
Unknown Facility
Basildon, SS16 5NL, United Kingdom
Unknown Facility
Bath, BA1 3NG, United Kingdom
Unknown Facility
Belfast, BT13 3BW, United Kingdom
Unknown Facility
Belfast, BT47 6SB, United Kingdom
Unknown Facility
Brighton, BN2 1ES, United Kingdom
Unknown Facility
Cambridge, CB2 0QQ, United Kingdom
Unknown Facility
Craigavon, BT63 5QQ, United Kingdom
Unknown Facility
Derby, DE22 3DT, United Kingdom
Unknown Facility
Glasgow, G11 6NK, United Kingdom
Unknown Facility
Harrow, HA1 3UJ, United Kingdom
Unknown Facility
Inverness, IV2 4RE, United Kingdom
Unknown Facility
Isle of Wight, 30 5TG., United Kingdom
Unknown Facility
Isleworth, TW7 6AF, United Kingdom
Unknown Facility
Leeds, United Kingdom
Unknown Facility
London, E1 2AT, United Kingdom
Unknown Facility
Manchester, M13 9WL, United Kingdom
Unknown Facility
Middlesex, UB1 3HW, United Kingdom
Unknown Facility
Newcastle upon Tyne, NE7 7DN, United Kingdom
Unknown Facility
Northampton, NN1 5BD, United Kingdom
Unknown Facility
Paddington, W2 1LA, United Kingdom
Unknown Facility
Plymouth, PL6 8BX, United Kingdom
Unknown Facility
Poole, BH15 2JB, United Kingdom
Unknown Facility
Romford, RM7 0AG, United Kingdom
Unknown Facility
Stoker on Trent, ST4 6QG, United Kingdom
Unknown Facility
West Bromwich, B71 4HJ, United Kingdom
Unknown Facility
Wrexham, LL137TD, United Kingdom
Related Publications (3)
Schrieks IC, Nozza A, Stahli BE, Buse JB, Henry RR, Malmberg K, Neal B, Nicholls SJ, Ryden L, Mellbin L, Svensson A, Wedel H, Weichert A, Lincoff AM, Tardif JC, Grobbee DE, Schwartz GG. Adiponectin, Free Fatty Acids, and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Acute Coronary Syndrome. Diabetes Care. 2018 Aug;41(8):1792-1800. doi: 10.2337/dc18-0158. Epub 2018 Jun 14.
PMID: 29903845DERIVEDLincoff AM, Tardif JC, Schwartz GG, Nicholls SJ, Ryden L, Neal B, Malmberg K, Wedel H, Buse JB, Henry RR, Weichert A, Cannata R, Svensson A, Volz D, Grobbee DE; AleCardio Investigators. Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trial. JAMA. 2014 Apr 16;311(15):1515-25. doi: 10.1001/jama.2014.3321.
PMID: 24682069DERIVEDLincoff AM, Tardif JC, Neal B, Nicholls SJ, Ryden L, Schwartz GG, Malmberg K, Buse JB, Henry RR, Wedel H, Weichert A, Cannata R, Grobbee DE. Evaluation of the dual peroxisome proliferator-activated receptor alpha/gamma agonist aleglitazar to reduce cardiovascular events in patients with acute coronary syndrome and type 2 diabetes mellitus: rationale and design of the AleCardio trial. Am Heart J. 2013 Sep;166(3):429-34. doi: 10.1016/j.ahj.2013.05.013. Epub 2013 Jul 26.
PMID: 24016490DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Clinical Trials
Hoffmann-La Roche
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 5, 2010
First Posted
January 6, 2010
Study Start
February 1, 2010
Primary Completion
November 1, 2013
Study Completion
November 1, 2013
Last Updated
November 2, 2016
Record last verified: 2016-11