Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans

NCT01024634 | Completed DMC

• 2 other identifiers: UIUC 095991R01HL093249-01A1
• Study Type: interventional
• Target: 91
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of age) African Americans when compared to Caucasians.

Conditions

Vascular Health; Autonomic Function

Keywords

Arterial stiffness; Endothelial function; Autonomic function; Inflammation

Outcome Measures

Primary Outcomes (1)

• Arterial function

  Pre, following a 4 week control period and after 8 weeks of exercise intervention

Secondary Outcomes (1)

• Autonomic function

  Pre, following a 4 week control period and following 8 weeeks of an exercise intervention

Study Arms (2)

African American Group

OTHER

A group of young African American males and females

Behavioral: Endurance Exercise

Caucasian Group

OTHER

a group of young Caucasian men and women

Behavioral: Endurance Exercise

Interventions

Endurance Exercise BEHAVIORAL

8 weeks of Endurance exercise training, 3-4 times per week, 45-60 minutes perr session

African American Group; Caucasian Group

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Subjects in good health with no cardiovascular, metabolic, or inflammatory disease, who do not use cardiovascular medications or antioxidant vitamin supplementation, including use of anti-inflammatory (including aspirin) or steroidal substances in the past 2 months will be inlcuded

You may not qualify if:

• Subjects who smoke, are severely obese (body mass index \> 35 kg/m2), or who have hypertension (blood pressure \>140/90mmHg), diabetes (fasting glucose \>110mg/dl), hyperlipidemia, inflammatory disease (rheumatoid arthritis and systemic lupus erythematosus, etc) or diagnosed cardiovascular disease including, coronary heart disease, hypertension and cardiac arrhythmia or renal disease, will be excluded

Sponsors & Collaborators

• University of Illinois at Urbana-Champaign: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

Kinesiology and Community Health Department, University of Illinois at Urbana-Champaign

Urbana, Illinois, 61801, United States

Location

Related Publications (1)

• Maroco JL, Lane AD, Ranadive SM, Yan H, Baynard T, Fernhall B. Aerobic Training Attenuates Differences Between Black and White Adults in Left Ventricular-Vascular Coupling and Wasted Pressure Effort. J Am Heart Assoc. 2024 Nov 5;13(21):e036107. doi: 10.1161/JAHA.124.036107. Epub 2024 Nov 4.

  PMID: 39494565 DERIVED

MeSH Terms

Conditions

Inflammation

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Bo Fernhall, Ph.D.

  University of Illinois at Urbana-Champaign

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 2, 2009
• First Posted: December 3, 2009
• Study Start: September 1, 2009
• Primary Completion: July 1, 2011
• Study Completion: December 1, 2012
• Last Updated: December 17, 2012

Record last verified: 2012-12

Locations

US (1)