Dietary Lipids as Primary Modulators of Carotenoid Absorption in Vegetables

NCT01006174 | Completed

• 1 other identifier: 0707005641
• Study Type: interventional
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research study is to determine how dietary fats and oils influence the absorption of beneficial plant pigments (carotenoids) from vegetables. The study will examine changes in blood carotenoids in response to eating a salad with different fats/oils.

Conditions

Absorption of Carotenoids From Vegetables

Outcome Measures

Primary Outcomes (1)

• Evaluating the impact of dietary lipid profiles on intestinal absorption of carotenoids from vegetables.

  66 days

Study Arms (3)

A

EXPERIMENTAL

Subjects will be assigned to consume 3 grams soybean oil, 8 grams canola oil, and 20 grams butter that is added to a salad.

Other: Soybean Oil; Other: Canola Oil; Other: Butter

B

EXPERIMENTAL

Subjects will be assigned to consume 8 grams soybean oil, 20 grams canola oil, and 3 grams butter that is added to a salad.

Other: Soybean Oil; Other: Canola Oil; Other: Butter

C

EXPERIMENTAL

Subjects will be assigned to consume 20 grams soybean oil, 3 grams canola oil, and 8 grams butter that is added to a salad.

Other: Soybean Oil; Other: Canola Oil; Other: Butter

Interventions

Soybean Oil OTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of soybean oil that is added to a salad.

A; B; C

Canola Oil OTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of canola oil that is added to a salad.

A; B; C

Butter OTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of butter that is added to a salad.

A; B; C

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age range: 18-50 years.
• Body mass index (BMI: weight (kg)/height (m2)) ranging from 20-29 kg/m²
• Weight stable (\<4.5 kg change within the last 3 months),
• Constant habitual activity pattern, not to exceed activities of a recreational level over the past 3 months.
• Must be pre-menopausal
• Have clinically normal blood profiles (specifically normal liver and kidney functions and fasting blood glucose of ≤110 mg/dl)
• Non-smoking
• Non-diabetic
• No current or planned pregnancy
• Not using any hormone-based contraceptive, e.g., pill, patch, injection, implants, etc.
• No current use of medication affecting lipid profile
• No intestinal disorders including lipid malabsorption, lactose intolerance
• No heavy consumption of alcohol (\>2 drinks per day)
• No current use of dietary supplements that affect cholesterol, (e.g. Benocol or fiber supplements) or a willingness to discontinue their use during the study.

You may not qualify if:

• Menopausal
• Diabetic
• Currently pregnant
• Currently using any type of hormone-based contraceptives, (e.g., pill, patch, injection, implants, etc.)
• Use of lipid altering medications

Sponsors & Collaborators

• Purdue University: lead

Study Sites (1)

Purdue University

West Lafayette, Indiana, 47906, United States

Location

MeSH Terms

Interventions

Soybean Oil; Rapeseed Oil; Butter

Intervention Hierarchy (Ancestors)

Dietary Fats, Unsaturated; Dietary Fats; Fats; Lipids; Fats, Unsaturated; Plant Oils; Oils; Plant Preparations; Biological Products; Complex Mixtures; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Dairy Products

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Wayne Campbell, Ph.D.

Study Record Dates

• First Submitted: October 30, 2009
• First Posted: November 2, 2009
• Study Start: March 1, 2009
• Primary Completion: February 1, 2010
• Study Completion: May 1, 2010
• Last Updated: January 17, 2013

Record last verified: 2013-01

Locations

US (1)