NCT00969124

Brief Summary

The Third Eye Retroscope is a device that can be used with a colonoscope to improve the ability of a physician to see areas of the colon that may be hidden from the view of the colonoscope. Previous studies have shown that physicians are able to detect additional polyps when they use the device along with the colonoscope. The purpose of this study is to determine whether physicians can detect greater numbers of additional polyps as they gain in experience with the device.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
328

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2009

Shorter than P25 for not_applicable

Geographic Reach
1 country

9 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2009

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

August 27, 2009

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 1, 2009

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2009

Completed
7.8 years until next milestone

Results Posted

Study results publicly available

July 26, 2017

Completed
Last Updated

July 26, 2017

Status Verified

June 1, 2017

Enrollment Period

9 months

First QC Date

August 27, 2009

Results QC Date

July 18, 2016

Last Update Submit

June 26, 2017

Conditions

Keywords

colonoscopypolypsadenomasmiss rates

Outcome Measures

Primary Outcomes (2)

  • Detection Rates for Adenomas

    Adenomas detected with the colonoscope alone vs. with the Retroscope

    During the colonoscopy procedure (up to 1 hour, average 25 minutes)

  • Detection Rates for All Polyps

    All polyps detected with the colonoscope alone vs. with the Retroscope

    During the colonoscopy procedure (up to 1 hour, average 25 minutes)

Secondary Outcomes (1)

  • Time Spent During Withdrawal Phase and Total Procedure

    During the colonoscopy procedure (up to 1 hour, average 25 minutes)

Study Arms (1)

Third Eye Retroscope

EXPERIMENTAL

All subjects underwent the same intervention, consisting of examination of the colon using a colonoscope along with the Third Eye Retroscope device, with removal of any polyps that were detected during the procedure.

Device: Third Eye Retroscope

Interventions

Third Eye Retroscope is used in conjunction with a standard colonoscope while performing colonoscopy

Third Eye Retroscope

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • The patient is undergoing colonoscopy for screening, for surveillance in follow-up of previous polypectomy or for diagnostic workup;
  • The patient must understand and provide written consent for the procedure.

You may not qualify if:

  • Patients with a history of colonic resection;
  • Patients with inflammatory bowel disease;
  • Patients with a personal history of polyposis syndrome;
  • Patients with suspected chronic stricture potentially precluding complete colonoscopy;
  • Patients with diverticulitis or toxic megacolon;
  • Patients with a history of radiation therapy to abdomen or pelvis.
  • Patients who are currently enrolled in another clinical investigation in which the intervention might compromise the safety of the patient's participation in this study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (9)

Florida Hospital

Celebration, Florida, 34747, United States

Location

University of Chicago

Chicago, Illinois, 60637, United States

Location

NorthShore University HealthSystem

Evanston, Illinois, 60201, United States

Location

University of Massachusetts

Worcester, Massachusetts, 01655, United States

Location

Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States

Location

Parkland Hospital

Dallas, Texas, 75235, United States

Location

Baylor University Medical Center

Dallas, Texas, 75246, United States

Location

S.W. Fort Worth Endoscopy Center

Fort Worth, Texas, 76132, United States

Location

North Hills Hospital

North Richland Hills, Texas, 76180, United States

Location

Related Publications (1)

  • DeMarco DC, Odstrcil E, Lara LF, Bass D, Herdman C, Kinney T, Gupta K, Wolf L, Dewar T, Deas TM, Mehta MK, Anwer MB, Pellish R, Hamilton JK, Polter D, Reddy KG, Hanan I. Impact of experience with a retrograde-viewing device on adenoma detection rates and withdrawal times during colonoscopy: the Third Eye Retroscope study group. Gastrointest Endosc. 2010 Mar;71(3):542-50. doi: 10.1016/j.gie.2009.12.021.

MeSH Terms

Conditions

Colorectal NeoplasmsPolypsAdenoma

Condition Hierarchy (Ancestors)

Intestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsDigestive System DiseasesGastrointestinal DiseasesColonic DiseasesIntestinal DiseasesRectal DiseasesPathological Conditions, AnatomicalPathological Conditions, Signs and SymptomsNeoplasms, Glandular and EpithelialNeoplasms by Histologic Type

Limitations and Caveats

No randomization or blinding and no separate control group. Determinations regarding adequacy of bowel cleansing and whether each polyp could have been detected with the colonoscope alone involved a judgement by the endoscopist.

Results Point of Contact

Title
Jack Higgins, MD - Chief Medical Officer
Organization
Avantis Medical Systems , Inc.

Study Officials

  • Daniel C DeMarco, MD

    Baylor Health Care System

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Masking Details
Open Label
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 27, 2009

First Posted

September 1, 2009

Study Start

January 1, 2009

Primary Completion

October 1, 2009

Study Completion

October 1, 2009

Last Updated

July 26, 2017

Results First Posted

July 26, 2017

Record last verified: 2017-06

Data Sharing

IPD Sharing
Will not share

Locations