NCT00951639

Brief Summary

The purpose of this study was to compare the acute effects of 5g of Cassia cinnamon, 50 minutes of endurance exercise performed at 70% of the heart rate reserve (correlated to VO2max), and 5g of cellulose placebo on blood glucose, serum insulin and insulin sensitivity following an oral glucose tolerance test 3 hours after administration of each intervention.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2008

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2008

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2009

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

August 3, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

August 4, 2009

Completed
Last Updated

March 17, 2022

Status Verified

March 1, 2022

Enrollment Period

1.2 years

First QC Date

August 3, 2009

Last Update Submit

March 3, 2022

Conditions

Insulin ResistanceImpaired Glucose TolerancePrediabetes

Keywords

CassiaCinnamonBlood GlucoseEndurance exerciseAcute exerciseOverweightObesityWomen

Outcome Measures

Primary Outcomes (1)

  • Blood Glucose

    Baseline, 0, 30, 60, 90 and 120 minutes following OGTT

Secondary Outcomes (1)

  • Serum Insulin

    Baseline, 0, 30, 60, 90 and 120 minutes following OGTT

Study Arms (3)

5g Cassia cinnamon

EXPERIMENTAL

Experimental treatment group

Dietary Supplement: Cassia cinnamon

50 minutes endurnace exercise

ACTIVE COMPARATOR

Endurance exercise treatment known to influence blood glucose

Procedure: 50 minutes exercise

5g Cellulose

PLACEBO COMPARATOR

Placebo equivalent in weight and appearance to experimental treatment

Dietary Supplement: Cellulose Powder

Interventions

Cassia cinnamonDIETARY_SUPPLEMENT

5g encapsulated ground bark administered once in experimental session

Also known as: Brand: Nature's Bounty
5g Cassia cinnamon
50 minutes exercisePROCEDURE

50 minutes treadmill endurance exercise at 70% of the heart rate reserve (correlated to VO2max)

50 minutes endurnace exercise
Cellulose PowderDIETARY_SUPPLEMENT

5g encapsulated powder administered during placebo experimental session

5g Cellulose

Eligibility Criteria

Age18 Years - 30 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Sedentary
  • BMI: 27-45
  • DXA body fat % greater than 30%
  • years of age
  • Healthy
  • From the Baylor University campus and surrounding community
  • Regular sleep habits

You may not qualify if:

  • Not regular users of any species of cinnamon
  • Not diagnosed with any metabolic disorder or chronic medical condition
  • Not taking prescription medications for 2 months before the study
  • Not taking ergogenic aids for 2 months before the study
  • Not taking oral contraceptives for 2 months before the study
  • No IUD placed for 2 months before the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Baylor University Department of Health, Human Performance, and Recreation

Waco, Texas, 76798, United States

Location

Related Publications (4)

  • Hlebowicz J, Darwiche G, Bjorgell O, Almer LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr. 2007 Jun;85(6):1552-6. doi: 10.1093/ajcn/85.6.1552.

    PMID: 17556692BACKGROUND

  • Hlebowicz J, Hlebowicz A, Lindstedt S, Bjorgell O, Hoglund P, Holst JJ, Darwiche G, Almer LO. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr. 2009 Mar;89(3):815-21. doi: 10.3945/ajcn.2008.26807. Epub 2009 Jan 21.

    PMID: 19158209BACKGROUND

  • Solomon TP, Blannin AK. Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans. Eur J Appl Physiol. 2009 Apr;105(6):969-76. doi: 10.1007/s00421-009-0986-9. Epub 2009 Jan 22.

    PMID: 19159947BACKGROUND

  • Solomon TP, Blannin AK. Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab. 2007 Nov;9(6):895-901. doi: 10.1111/j.1463-1326.2006.00694.x.

    PMID: 17924872BACKGROUND

MeSH Terms

Conditions

Insulin ResistanceGlucose IntolerancePrediabetic StateOverweightObesity

Interventions

Exercise

Condition Hierarchy (Ancestors)

HyperinsulinismGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesHyperglycemiaDiabetes MellitusEndocrine System DiseasesOvernutritionNutrition DisordersBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Darryn S Willoughby, Ph.D.

    Baylor University

    STUDY CHAIR

  • Jean L Gutierrez, Ph.D.

    Baylor University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
SUPPORTIVE CARE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 3, 2009

First Posted

August 4, 2009

Study Start

February 1, 2008

Primary Completion

May 1, 2009

Study Completion

May 1, 2009

Last Updated

March 17, 2022

Record last verified: 2022-03

Locations

US(1)