NCT00938379|UnknownPhase 3DMC
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Sponsor study identifier
interventional
5,000
1 country
1
Study Start
July 2009
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2010
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
June 2011
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Rural communities involved in agriculture are often at highest risk of insect-borne diseases in Southeast (SE) Asia. Skin-applied insect repellents may prove a useful means of reducing mosquito-borne diseases for those people working outdoors in high risk areas. This trial is evaluating the use of insect repellent (20% diethyltoluamide) to reduce incidence of malaria, Japanese Encephalitis and Dengue. The investigators will recruit up to 1000 households from 100 villages in rural Laos. In each house the investigators shall recruit up to 5 individuals. Half of households will be randomised to repellent, half to a placebo. All individuals will be provided with insecticide treated bed nets for use at night. All household occupants will be followed for 7 months to record malaria cases by Rapid Diagnostic Test every month. Blood spots will be collected at start and end of study to measure Japanese Encephalitis and Dengue. All positive cases will be promptly treated. Outcome will be reduction in number of malaria cases (primary outcome) and Dengue/Japanese Encephalitis (secondary outcomes).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2011
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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July 2009
Date type not reportedThis date has not been verified as actual or estimated.
July 10, 2009
Actual (reported)July 13, 2009
Actual (reported)December 2010
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
June 2011
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
reduction in malaria incidence
monthly over 7 months
Reduction in Japanese Encephalitis and / or Dengue infections
After 7 months intervention
experimental intervention
skin-applied repellent lotion
Identical base formulation of lotion but without any deet active
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Rural villages in Attepu and Sekong Provinces, Laos PDR
Pakse, Attepu, Laos
Chen-Hussey V, Carneiro I, Keomanila H, Gray R, Bannavong S, Phanalasy S, Lindsay SW. Can topical insect repellents reduce malaria? A cluster-randomised controlled trial of the insect repellent N,N-diethyl-m-toluamide (DEET) in Lao PDR. PLoS One. 2013 Aug 14;8(8):e70664. doi: 10.1371/journal.pone.0070664. eCollection 2013.
Nigel Hill, PhD
London School of Hygiene and Tropical Medicine
First Submitted
July 10, 2009
First Posted
July 13, 2009
Study Start
July 2009
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2010
Estimated (date passed)Three Alternative Drug Regimens for Malaria Seasonal Preventive Treatment in Senegal
Evaluation of Combined Use of ITN's and Insect Repellents Against Malaria
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
June 2011
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
July 14, 2009
Record last verified: 2009-07
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Source: ClinicalTrials.gov.
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