NCT00442442

Brief Summary

Although mosquito coils are widely used, there is no robust evidence that their use can provide clinical reduction in malaria. This study will randomise 4 groups of 400 houses, each with 5 people, in rural China and monitor cases of malaria in each group each month for 6 months. The treatment groups will include Coils, Treated bed nets, Coils plus treated bed nets, or no treatment (control). All cases detected will be given prompt appropriate treatment.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
8,000

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Apr 2007

Shorter than P25 for phase_3

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 1, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

March 2, 2007

Completed
1 month until next milestone

Study Start

First participant enrolled

April 1, 2007

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2007

Completed
Last Updated

October 31, 2007

Status Verified

October 1, 2007

First QC Date

March 1, 2007

Last Update Submit

October 30, 2007

Conditions

Malaria

Keywords

Malariamosquito controlmosquito coilsLLIN

Outcome Measures

Primary Outcomes (1)

  • Malaria cases

    6 months

Secondary Outcomes (3)

  • Fever reports

    6 months

  • User acceptance

    6 months

  • entomological data

    6 months

Study Arms (4)

1

NO INTERVENTION

No treatment control

2

ACTIVE COMPARATOR

LLIN Nets

Device: LLIN

3

EXPERIMENTAL

Mosquito Coils

Device: mosquito coils

4

EXPERIMENTAL

Mosquito coils \& LLIN

Device: mosquito coils

Interventions

mosquito coilsDEVICE

mosquito coil / night mosquito coil \& LLIN / night

34
LLINDEVICE

Sleep under LLIN every night

2

Eligibility Criteria

Age6 Years+
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • years plus,
  • No allergy to products in use,
  • Not pregnant / breast feeding

You may not qualify if:

  • Not sleeping at home each night

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Yunnan Institute of Parasitic Diseases

Pu'er, Yunnan, 65000, China

Location

Related Publications (1)

  • Hill N, Zhou HN, Wang P, Guo X, Carneiro I, Moore SJ. A household randomized, controlled trial of the efficacy of 0.03% transfluthrin coils alone and in combination with long-lasting insecticidal nets on the incidence of Plasmodium falciparum and Plasmodium vivax malaria in Western Yunnan Province, China. Malar J. 2014 May 31;13:208. doi: 10.1186/1475-2875-13-208.

    PMID: 24885993DERIVED

MeSH Terms

Conditions

Malaria

Condition Hierarchy (Ancestors)

Protozoan InfectionsParasitic DiseasesInfectionsMosquito-Borne DiseasesVector Borne Diseases

Study Officials

  • Nigel Hill, PhD

    London School of Hygiene and Tropical Medicine

    PRINCIPAL INVESTIGATOR

  • Hong Ning Zhou, MSc

    Yunnan Institute of Parasitic Diseases

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER

Study Record Dates

First Submitted

March 1, 2007

First Posted

March 2, 2007

Study Start

April 1, 2007

Study Completion

December 1, 2007

Last Updated

October 31, 2007

Record last verified: 2007-10

Locations

CN(1)