The Canadian Cohort Obstructive Lung Disease

NCT00920348 | Unknown DMC

• 1 other identifier: IRO-93326
• Study Type: observational
• Target: 1,500
• Locations: 1 country
• Sites: 9

Brief Summary

Abstract Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in Canada. COPD is not just a disease of men, nor is it solely a disease in old age. Women have been underrepresented and early disease has not been studied. Underdiagnosis of COPD remains a significant problem, and it may indicate an unmet healthcare need. This can potentially results not only in a patient been misinformed, but can lead to incorrect management. Epidemiological research is needed to develop a framework to combat this major health problem, by better characterization of the population of men and women at risk and patients with early disease, by better understanding which factors modifiable through health interventions are related to health perception (health-related quality of life) and disease evolution. This will be possible through a nationwide study, the Canadian Cohort Obstructive Lung disease (CanCOLD), a prospective longitudinal study. The CanCOLD study is built on the current ongoing prevalence nationwide study, the Canadian Obstructive Lung disease "COLD" study. The CanCOLD will be the first study to assess prevalence of disease across Canada and its consequence in men and women, and to evaluate a conceptual model of disease severity based on patient's health perception (health-related quality of life). Ultimately, this project will extend to a longitudinal follow up (3 years or beyond) and will allow to have a better understanding of the lifestyle risk factors, not only smoking but also diet, physical activity, and co morbid conditions. This will be a great asset to shift from management of a single risk factor (tobacco control) to total COPD risk management. The results of the study will greatly help to assist decision makers in developing policies to improve the diagnosis, the management of COPD and to optimize health care services use.

Conditions

COPD; Chronic Obstructive Pulmonary Disease

Keywords

Chronic obstructive pulmonary disease; COPD; Cohort study; prospective longitudinal study; tissue bank

Outcome Measures

Primary Outcomes (1)

• What risk factors other than smoking determine the development and progression of COPD.

  One visit a year every 18 months

Secondary Outcomes (2)

• What are the combinations of the disease and patient attributes that differentiate individuals (men/women) with COPD as they relate to relevant outcomes (symptoms, exacerbations, disease progression or death)

  One visit a year 18 months

• Is early detection of COPD with spirometry meaningful according to sex and ageing.

  One visit a year 18 months

Study Arms (4)

Group 1

COPD moderate-severe(GOLD2-4)(post-BD FEV1/FVC\<0.70 and FEV1\<80% of pred.)

Group 2

COPD mild (GOLD1)(post-BD FEV1/FVC\<0.70 AND FEV1\>=80% of pred.)

Group 3

COPD at risk (ever smoker with post-BD FEV1/FVC\>=0.70)

Group 4

"Healthy control" never smokers without respiratory disease (post-BD FEV1/FVC\>=0.70.

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects' selection and participation in CanCOLD- longitudinal cohort: Subjects will be recruited from the study site participants (total from cross-sectional ≈5,000 subjects, men and women).

Sponsors & Collaborators

• McGill University Health Centre/Research Institute of the McGill University Health Centre: lead
• Canadian Institutes of Health Research (CIHR): collaborator
• GlaxoSmithKline: collaborator
• AstraZeneca: collaborator
• Pfizer: collaborator
• Boehringer Ingelheim: collaborator
• Novartis: collaborator
• Takeda: collaborator
• Merck Sharp & Dohme LLC: collaborator
• Almirall, SAS: collaborator

Study Sites (9)

Health Sciences Centre

Calgary, Alberta, T2N 4N1, Canada

Location

St-Paul's Hospital

Vancouver, British Columbia, V6Z 1Y6, Canada

Location

Halifax Infirmary

Halifax, Nova Scotia, B3H 3A7, Canada

Location

Kingston General Hospital

Kingston, Ontario, K7L 2V6, Canada

Location

Ottawa Hospital General

Ottawa, Ontario, K1H 8L6, Canada

Location

University of Toronto

Toronto, Ontario, M5T 2S8, Canada

Location

Montreal Chest Institute

Montreal, Quebec, H2X 2P4, Canada

Location

Royal University Hospital

Saskatoon, Saskatchewan, S7N 0W8, Canada

Location

Institut universitaire de cardiologie et de pneumologie de Québec

Québec, G1V 4G5, Canada

Location

Related Publications (14)

• Cordero AIH, Li X, Yang CX, Ambalavanan A, MacIsaac JL, Kobor MS, Doiron D, Tan W, Bourbeau J, Sin DD, Duan Q, Leung JM; CanCOLD Collaborative Research Group. Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation. BMC Pulm Med. 2025 Apr 9;25(1):168. doi: 10.1186/s12890-025-03634-9.

  PMID: 40205553 DERIVED

• Ekstrom M, Lewthwaite H, Li PZ, Bourbeau J, Tan WC, Jensen D; CanCOLD Collaborative Research Group. Identifying Abnormal Exertional Breathlessness in COPD: Comparing Modified Medical Research Council and COPD Assessment Test With Cardiopulmonary Exercise Testing. Chest. 2025 Mar;167(3):697-711. doi: 10.1016/j.chest.2024.10.027. Epub 2024 Oct 28.

  PMID: 39490971 DERIVED

• Virdee S, Tan WC, Hogg JC, Bourbeau J, Hague CJ, Kirby M; CanCOLD Collaborative Research Group. CT Chest Imaging Using Normalized Join-Count: Predicting Emphysema Progression in the CanCOLD Study. Radiology. 2024 Jul;312(1):e233265. doi: 10.1148/radiol.233265.

  PMID: 39012250 DERIVED

• Phillips DB, James MD, Vincent SG, Elbehairy AF, Neder JA, Kirby M, Ora J, Day AG, Tan WC, Bourbeau J, O'Donnell DE; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network. Physiological Characterization of Preserved Ratio Impaired Spirometry in the CanCOLD Study: Implications for Exertional Dyspnea and Exercise Intolerance. Am J Respir Crit Care Med. 2024 Jun 1;209(11):1314-1327. doi: 10.1164/rccm.202307-1184OC.

  PMID: 38170674 DERIVED

• Abozid H, Kirby M, Nasir N, Hartl S, Breyer-Kohansal R, Breyer MK, Burghuber OC, Bourbeau J, Wouters EFM, Tan W; CanCOLD Collaborative research Group and the Canadian Respiratory Research Network. CT airway remodelling and chronic cough. BMJ Open Respir Res. 2023 May;10(1):e001462. doi: 10.1136/bmjresp-2022-001462.

  PMID: 37173074 DERIVED

• Ross BA, Doiron D, Benedetti A, Aaron SD, Chapman K, Hernandez P, Maltais F, Marciniuk D, O'Donnell DE, Sin DD, Walker BL, Tan W, Bourbeau J; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network. Short-term air pollution exposure and exacerbation events in mild to moderate COPD: a case-crossover study within the CanCOLD cohort. Thorax. 2023 Oct;78(10):974-982. doi: 10.1136/thorax-2022-219619. Epub 2023 May 5.

  PMID: 37147124 DERIVED

• Krishnan S, Tan WC, Farias R, Aaron SD, Benedetti A, Chapman KR, Hernandez P, Maltais F, Marciniuk DD, O'Donnell DE, Sin DD, Walker B, Bourbeau J; Canadian Cohort Obstructive Lung Disease Collaborative Research Group and the Canadian Respiratory Research Network. Impaired Spirometry and COPD Increase the Risk of Cardiovascular Disease: A Canadian Cohort Study. Chest. 2023 Sep;164(3):637-649. doi: 10.1016/j.chest.2023.02.045. Epub 2023 Mar 4.

  PMID: 36871842 DERIVED

• Moslemi A, Makimoto K, Tan WC, Bourbeau J, Hogg JC, Coxson HO, Kirby M; Canadian Cohort of Obstructive Lung Disease. Quantitative CT Lung Imaging and Machine Learning Improves Prediction of Emergency Room Visits and Hospitalizations in COPD. Acad Radiol. 2023 Apr;30(4):707-716. doi: 10.1016/j.acra.2022.05.009. Epub 2022 Jun 8.

  PMID: 35690537 DERIVED

• Phillips DB, Elbehairy AF, James MD, Vincent SG, Milne KM, de-Torres JP, Neder JA, Kirby M, Jensen D, Stickland MK, Guenette JA, Smith BM, Aaron SD, Tan WC, Bourbeau J, O'Donnell DE; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network. Impaired Ventilatory Efficiency, Dyspnea, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease: Results from the CanCOLD Study. Am J Respir Crit Care Med. 2022 Jun 15;205(12):1391-1402. doi: 10.1164/rccm.202109-2171OC.

  PMID: 35333135 DERIVED

• Tan WC, Bourbeau J, Nadeau G, Wang W, Barnes N, Landis SH, Kirby M, Hogg JC, Sin DD; CanCOLD Collaborative Research Group; authors would also like to thank the men and women who participated in the study and individuals in the CanCOLD Collaborative Research Group not listed as authors:. High eosinophil counts predict decline in FEV1: results from the CanCOLD study. Eur Respir J. 2021 May 27;57(5):2000838. doi: 10.1183/13993003.00838-2020. Print 2021 May.

  PMID: 33303555 DERIVED

• Lewthwaite H, Elsewify O, Niro F, Bourbeau J, Guenette JA, Maltais F, Marciniuk DD, O'Donnell DE, Smith BM, Stickland MK, Tan WC, Jensen D; CanCOLD Collaborative Research Group; Canadian Respiratory Research Network. Normative Cardiopulmonary Exercise Test Responses at the Ventilatory Threshold in Canadian Adults 40 to 80 Years of Age. Chest. 2021 May;159(5):1922-1933. doi: 10.1016/j.chest.2020.11.009. Epub 2020 Nov 18.

  PMID: 33217419 DERIVED

• Barrecheguren M, Pinto L, Mostafavi-Pour-Manshadi SM, Tan WC, Li PZ, Aaron SD, Benedetti A, Chapman KR, Walker B, Fitzgerald JM, Hernandez P, Maltais F, Marciniuk DD, O'Donnell DE, Sin DD, Bourbeau J; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network. Identification and definition of asthma-COPD overlap: The CanCOLD study. Respirology. 2020 Aug;25(8):836-849. doi: 10.1111/resp.13780. Epub 2020 Feb 16.

  PMID: 32064708 DERIVED

• Gupta N, Pinto L, Benedetti A, Li PZ, Tan WC, Aaron SD, Chapman KR, FitzGerald JM, Hernandez P, Marciniuk DD, Maltais F, O'Donnell DE, Sin D, Walker BL, Bourbeau J; Canadian Respiratory Research Network and the CanCOLD Collaborative Research Group. The COPD Assessment Test: Can It Discriminate Across COPD Subpopulations? Chest. 2016 Nov;150(5):1069-1079. doi: 10.1016/j.chest.2016.06.016. Epub 2016 Jun 27.

  PMID: 27364603 DERIVED

• Tan WC, Sin DD, Bourbeau J, Hernandez P, Chapman KR, Cowie R, FitzGerald JM, Marciniuk DD, Maltais F, Buist AS, Road J, Hogg JC, Kirby M, Coxson H, Hague C, Leipsic J, O'Donnell DE, Aaron SD; CanCOLD Collaborative Research Group. Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study. Thorax. 2015 Sep;70(9):822-9. doi: 10.1136/thoraxjnl-2015-206938. Epub 2015 Jun 5.

  PMID: 26048404 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood sampling * Biomarkers:IL-6, CRP, CC-16, SP-D" * DNA for genetics, epigenetic and RNA for transcriptomics * Markers for cardiovascular diseases: LDL, LDL and HDL sizes, Apo B, Apo A1, CRP, IL6, TNF alpha, Adiponectine, Leptine, Glucose and Insulin.

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jean Bourbeau, M.D., M.Sc.

  McGill University Health Centre/Research Institute of the McGill University Health Centre

  PRINCIPAL INVESTIGATOR

• Wan Tan, M.D.

  CAAA University of British Columbia

  PRINCIPAL INVESTIGATOR

• François Maltais, M.D.

  CFBA Université Laval

  PRINCIPAL INVESTIGATOR

• Shawn Aaron, M.D., M.Sc.

  OHGC Ottawa Hospital General Campus

  PRINCIPAL INVESTIGATOR

• Denis O'Donnell, M.D.

  CEDA Queen's University (Kinsgston)

  PRINCIPAL INVESTIGATOR

• Darcy D Marciniuk, M.D.

  CCAA University of Saskatchewan

  PRINCIPAL INVESTIGATOR

• Robert Cowie, M.D.

  CBBA University of Calgary

  PRINCIPAL INVESTIGATOR

• Kenneth R. Chapman, M.D., M.Sc.

  CEAA University of Toronto

  PRINCIPAL INVESTIGATOR

• Paul Hernandez, M.D.

  CHAA Dalhousie University (Nova Scotia)

  PRINCIPAL INVESTIGATOR

• Mark J. FitzGerald, M.D.

  CAAA University of British Columbia

  PRINCIPAL INVESTIGATOR

• Donald Sin, M.D.

  CAAA University of British Columbia

  PRINCIPAL INVESTIGATOR

• Andrea Benedetti, Ph.D.

  INUD McGill University Healty Center

  PRINCIPAL INVESTIGATOR

• Yves Lacasse, M.D., M.Sc.

  CPVR Institut universitaire de cardiologie et de pneumologie de Québec

  PRINCIPAL INVESTIGATOR

• Pierre Ernst, M.D.

  McGill University

  PRINCIPAL INVESTIGATOR

• Harvey Coxson, M.D.

  University of British Columbia

  PRINCIPAL INVESTIGATOR

• Roger Goldstein, M.D.

  CEAA University of Toronto

  PRINCIPAL INVESTIGATOR

• Carlo Marra, Ph.D.

  CAAA University of British Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, M.Sc.

Study Record Dates

• First Submitted: June 12, 2009
• First Posted: June 15, 2009
• Study Start: January 1, 2010
• Primary Completion: December 1, 2022
• Study Completion: December 1, 2022
• Last Updated: August 27, 2018

Record last verified: 2018-08

Data Sharing

• IPD Sharing: Will share

Locations

CA (9)