Metabolic Fate Modifications of Saturated Fats After an Overfeeding
SURNUT
1 other identifier
interventional
40
1 country
1
Brief Summary
The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding. The method is based on the incorporation of a stable isotopic tracer (d31\_palmitic acid, d31\_C16) in lipoprotein triglycerides (TG-CHYLOMICRON and TG-VLDL) and in free fatty acids (FFA).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable obesity
Started Sep 2005
Longer than P75 for not_applicable obesity
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2005
CompletedFirst Submitted
Initial submission to the registry
May 20, 2009
CompletedFirst Posted
Study publicly available on registry
May 21, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2010
CompletedJune 23, 2011
June 1, 2011
4.3 years
May 20, 2009
June 22, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Post prandial partitioning of exogenous lipids
Before and after overfeeding
Secondary Outcomes (1)
Genes expression in adipose and muscle tissues
Before and after overfeeding
Interventions
100g per day of cheese + 40g per day of almonds + 20g per day of butter
Eligibility Criteria
You may qualify if:
- to 55 years old
- BMI 18 to 30 kg/m²
- Stable physical activity
- Safety subject during medical consultation
You may not qualify if:
- Medical or surgical history which may affect energy expenditure (renal -cardiovascular -hepatic- endocrine-inflammatory diseases)
- Drug use that could affect energy expenditure (steroids, nicotine substitutes, thyroid hormones)
- Eating disorder
- Intensive sportive activity
- Subjects who Smoke
- Claustrophobic subjects
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Centre de recherche en nutrition humaine Rhone-Alpes
Pierre-Bénite, 69495, France
Related Publications (3)
Segrestin B, Moreno-Navarrete JM, Seyssel K, Alligier M, Meugnier E, Nazare JA, Vidal H, Fernandez-Real JM, Laville M. Adipose Tissue Expansion by Overfeeding Healthy Men Alters Iron Gene Expression. J Clin Endocrinol Metab. 2019 Mar 1;104(3):688-696. doi: 10.1210/jc.2018-01169.
PMID: 30260393DERIVEDSeyssel K, Alligier M, Meugnier E, Chanseaume E, Loizon E, Canto C, Disse E, Lambert-Porcheron S, Brozek J, Blond E, Rieusset J, Morio B, Laville M, Vidal H. Regulation of energy metabolism and mitochondrial function in skeletal muscle during lipid overfeeding in healthy men. J Clin Endocrinol Metab. 2014 Jul;99(7):E1254-62. doi: 10.1210/jc.2013-4379. Epub 2014 Mar 31.
PMID: 24684464DERIVEDAlligier M, Meugnier E, Debard C, Lambert-Porcheron S, Chanseaume E, Sothier M, Loizon E, Hssain AA, Brozek J, Scoazec JY, Morio B, Vidal H, Laville M. Subcutaneous adipose tissue remodeling during the initial phase of weight gain induced by overfeeding in humans. J Clin Endocrinol Metab. 2012 Feb;97(2):E183-92. doi: 10.1210/jc.2011-2314. Epub 2011 Dec 7.
PMID: 22162470DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Martine Laville, PhD, MD
Centre de Recherche en Nutrition Humaine Rhône-Alpes
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
May 20, 2009
First Posted
May 21, 2009
Study Start
September 1, 2005
Primary Completion
December 1, 2009
Study Completion
March 1, 2010
Last Updated
June 23, 2011
Record last verified: 2011-06