NCT00905554

Brief Summary

Unsedated colonoscopy is characterized by lower costs, recovery time and incidence of drug-related side effects, although it may be painful for the patient. Based on recent reports, the investigators designed this randomized controlled trial hypothesizing that the use of water irrigation versus air insufflation during the insertion phase of colonoscopy might increase the global tolerability of the examination and the proportion of patients undergoing complete colonoscopy without sedation.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
230

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Apr 2009

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2009

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

May 15, 2009

Completed
5 days until next milestone

First Posted

Study publicly available on registry

May 20, 2009

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2009

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2010

Completed
1.7 years until next milestone

Results Posted

Study results publicly available

October 25, 2011

Completed
Last Updated

October 25, 2011

Status Verified

September 1, 2011

Enrollment Period

3 months

First QC Date

May 15, 2009

Results QC Date

August 5, 2011

Last Update Submit

September 15, 2011

Conditions

Keywords

sedationwarm water

Outcome Measures

Primary Outcomes (1)

  • Number of Patients Undergoing Complete Unsedated Colonoscopy

    6-9 months

Secondary Outcomes (1)

  • Evaluation of Pain and Tolerability Scores

    6-9 months

Study Arms (2)

warm water

EXPERIMENTAL

warm water irrigation during the insertion phase of colonoscopy

Procedure: warm water irrigation

air

ACTIVE COMPARATOR

air insufflation during the insertion phase of colonoscopy

Procedure: air insufflation

Interventions

warm water irrigation during insertion phase of colonoscopy

warm water

air insufflation during the insertion phase of colonoscopy

air

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • adult outpatients willing to undergo colonoscopy without routine initial sedation

You may not qualify if:

  • refuse to initiate colonoscopy without routine sedation
  • inadequate bowel preparation
  • incapacity to give informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Valduce Hospital

Como, CO, 22100, Italy

Location

Related Publications (1)

  • Radaelli F, Paggi S, Amato A, Terruzzi V. Warm water infusion versus air insufflation for unsedated colonoscopy: a randomized, controlled trial. Gastrointest Endosc. 2010 Oct;72(4):701-9. doi: 10.1016/j.gie.2010.06.025.

Results Point of Contact

Title
Vittorio Terruzzi, MD
Organization
Valduce Hospital - Como - Italy

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD

Study Record Dates

First Submitted

May 15, 2009

First Posted

May 20, 2009

Study Start

April 1, 2009

Primary Completion

July 1, 2009

Study Completion

February 1, 2010

Last Updated

October 25, 2011

Results First Posted

October 25, 2011

Record last verified: 2011-09

Locations