The Use of Narrow Band Imaging in Screening Colonoscopy
The Impact of Narrow Band Imaging in Screening Colonoscopy: a Randomized Controlled Trial.
1 other identifier
interventional
206
0 countries
N/A
Brief Summary
Narrow band imaging (NBI) is an imaging technique that allows a better definition of capillary pattern and improves the contrast between adenomas and the surrounding mucosa. Conflicting data exist on the ability of NBI in to improve detection of colonic neoplasm; the impact of NBI is being tested in several screening scenarios. The investigators evaluated whether the routine use of NBI, compared to white light (WL), during the withdrawal phase of screening colonoscopy improved adenoma detection.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Nov 2007
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2008
CompletedFirst Submitted
Initial submission to the registry
January 22, 2009
CompletedFirst Posted
Study publicly available on registry
May 27, 2009
CompletedResults Posted
Study results publicly available
May 27, 2009
CompletedApril 26, 2021
March 1, 2021
5 months
January 22, 2009
January 22, 2009
March 30, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Adenoma Detection
Detection of adenoma, defined as the number of patients with \> 1 adenoma, under White Light or NBI visualization
duration of colonoscopy procedure
Secondary Outcomes (1)
Detection of Flat and/or Depressed Adenomas
duration of colonoscopy procedure
Study Arms (2)
1
NO INTERVENTIONstandard white light
2
EXPERIMENTALNarrow Band Imaging
Interventions
Eligibility Criteria
You may qualify if:
- year-old asymptomatic subjects at average-risk of CRC
- positive FOBT participating in a national mass-screening program and referred for colonoscopy
You may not qualify if:
- ongoing anticoagulation therapy
- inadequate bowel cleansing
- incomplete colonoscopy
- refusing to participate
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Valduce Hospitallead
Related Publications (2)
Machida H, Sano Y, Hamamoto Y, Muto M, Kozu T, Tajiri H, Yoshida S. Narrow-band imaging in the diagnosis of colorectal mucosal lesions: a pilot study. Endoscopy. 2004 Dec;36(12):1094-8. doi: 10.1055/s-2004-826040.
PMID: 15578301BACKGROUNDChiu HM, Chang CY, Chen CC, Lee YC, Wu MS, Lin JT, Shun CT, Wang HP. A prospective comparative study of narrow-band imaging, chromoendoscopy, and conventional colonoscopy in the diagnosis of colorectal neoplasia. Gut. 2007 Mar;56(3):373-9. doi: 10.1136/gut.2006.099614. Epub 2006 Sep 27.
PMID: 17005766BACKGROUND
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr Vittorio Terruzzi, Director of Gastroenterology Unit
- Organization
- Gastroenterology Unit, Valduce Hospital - Como - Italy
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
January 22, 2009
First Posted
May 27, 2009
Study Start
November 1, 2007
Primary Completion
April 1, 2008
Study Completion
April 1, 2008
Last Updated
April 26, 2021
Results First Posted
May 27, 2009
Record last verified: 2021-03