Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx

NCT00899340 | Completed DMC

• 3 other identifiers: VICC HN 0624VU-VICC-HN-0624VU-VICC-IRB-060380
• Study Type: observational
• Target: 54
• Locations: 0 countries
• Sites: N/A

Brief Summary

RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx. PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.

Conditions

Head and Neck Cancer

Keywords

recurrent squamous cell carcinoma of the oropharynx; stage I squamous cell carcinoma of the oropharynx; stage II squamous cell carcinoma of the oropharynx; stage III squamous cell carcinoma of the oropharynx; stage IV squamous cell carcinoma of the oropharynx

Outcome Measures

Primary Outcomes (2)

• Development of biomarkers for early detection or recurrence surveillance

  after 7 months of tissue collection

• Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx

  after 7months of tissue collection

Interventions

gene expression analysis GENETIC

profiles of HPV(+) and (-) HNSCCs

microarray analysis GENETIC

microarray analysis

Also known as: SAM - significance Analysis of microarrays

protein expression analysis GENETIC

protein expression analysis

immunohistochemistry staining method OTHER

immunohistochemistry staining method

laboratory biomarker analysis OTHER

laboratory biomarker analysis

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

community sample

You may qualify if:

• Diagnosis of squamous cell carcinoma of the oropharynx
• Tumor tissue samples available from Vanderbilt Head and Neck Tumor Repository and Vanderbilt Pathology archives

You may not qualify if:

• Not specified
• PRIOR CONCURRENT THERAPY:
• Not specified

Sponsors & Collaborators

• Vanderbilt-Ingram Cancer Center: lead
• National Cancer Institute (NCI): collaborator

MeSH Terms

Conditions

Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck

Interventions

Gene Expression Profiling; Microarray Analysis; Immunohistochemistry

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Carcinoma, Squamous Cell; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type

Intervention Hierarchy (Ancestors)

Genetic Techniques; Investigative Techniques; Microchip Analytical Procedures; Histocytochemistry; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Histological Techniques; Immunologic Techniques

Study Officials

• Barbara Murphy, MD

  Vanderbilt-Ingram Cancer Center

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine, Medical Oncologist

Study Record Dates

• First Submitted: May 9, 2009
• First Posted: May 12, 2009
• Study Start: May 1, 2006
• Primary Completion: March 1, 2008
• Study Completion: March 1, 2008
• Last Updated: April 2, 2013

Record last verified: 2013-03