NCT00896948

Brief Summary

RATIONALE: Studying proteins in head and neck cancer cells in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at proteins in head and neck cancer cells.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2005

Completed
4 years until next milestone

First Submitted

Initial submission to the registry

May 9, 2009

Completed
3 days until next milestone

First Posted

Study publicly available on registry

May 12, 2009

Completed
Last Updated

March 14, 2017

Status Verified

March 1, 2017

First QC Date

May 9, 2009

Last Update Submit

March 10, 2017

Conditions

Head and Neck Cancer

Keywords

head and neck cancer

Outcome Measures

Primary Outcomes (3)

  • Function and mechanism of LZAP in regulating ARF

  • Mechanism and biological consequences of LZAP inhibition of NF-κB

  • Determination of LZAP tumor suppressor activity

Interventions

Southern blottingGENETIC
TdT-mediated dUTP nick end labeling assayGENETIC
gene expression analysisGENETIC
protein expression analysisGENETIC
flow cytometryOTHER
fluorescent antibody techniqueOTHER
immunoenzyme techniqueOTHER
immunohistochemistry staining methodOTHER
immunologic techniqueOTHER

Eligibility Criteria

AgeUp to 120 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
DISEASE CHARACTERISTICS: * Head and neck cancer tumor cell line PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (3)

Vanderbilt-Ingram Cancer Center - Cool Springs

Nashville, Tennessee, 37064, United States

Location

Vanderbilt-Ingram Cancer Center at Franklin

Nashville, Tennessee, 37064, United States

Location

Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, 37232-6838, United States

Location

MeSH Terms

Conditions

Head and Neck Neoplasms

Interventions

Blotting, SouthernGene Expression ProfilingFlow CytometryFluorescent Antibody TechniqueImmunoenzyme TechniquesImmunohistochemistryImmunologic Techniques

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasms

Intervention Hierarchy (Ancestors)

ElectrophoresisChemistry Techniques, AnalyticalInvestigative TechniquesElectrochemical TechniquesMolecular Probe TechniquesGenetic TechniquesCell SeparationCytological TechniquesClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisCytophotometryFluorometryLuminescent MeasurementsPhotometryHistocytochemistryHistological TechniquesImmunoassay

Study Officials

  • Wendell G. Yarbrough, MD, FACS

    Vanderbilt-Ingram Cancer Center

    STUDY CHAIR

Study Design

Study Type
observational
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 9, 2009

First Posted

May 12, 2009

Study Start

May 1, 2005

Last Updated

March 14, 2017

Record last verified: 2017-03

Locations

US(3)