Biomarkers in Patients at Risk of Developing Myelodysplastic Syndrome or Other Disorders and in Healthy Participants

NCT00899327 | Unknown

• 3 other identifiers: CDR0000595855MRC-MDS-BIO1EU-20852
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

RATIONALE: Studying samples of blood and bone marrow in the laboratory from patients at risk of developing myelodysplastic syndrome may help doctors learn more about changes that occur in DNA and identify biomarkers related to disorders of the blood and bone marrow. PURPOSE: This research study is looking at biomarkers in patients at risk of developing myelodysplastic syndrome or other disorders and in healthy participants.

Conditions

Leukemia; Myelodysplastic Syndromes

Keywords

myelodysplastic syndromes; acute myeloid leukemia

Outcome Measures

Primary Outcomes (1)

• Identification of novel biomarkers of disease

Secondary Outcomes (2)

• Identification of novel biomarkers of disease progression from myelodysplastic syndromes to acute myeloid leukemia

• Comprehension of genesis of anemia in cancer

Interventions

DNA methylation analysis GENETIC

RNA analysis GENETIC

cytogenetic analysis GENETIC

gene expression analysis GENETIC

mutation analysis GENETIC

polymerase chain reaction GENETIC

protein expression analysis GENETIC

laboratory biomarker analysis OTHER

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

DISEASE CHARACTERISTICS: * Must meet 1 of the following criteria: * Being investigated for a potential blood disorder due to abnormal blood count * Patients with a known blood disorder who are having a bone marrow sample taken as part of the assessment of that disorder * Patients undergoing hip replacement surgery at Nuffield Orthopaedic Centre, Oxford meeting the following criteria: * Not on treatment likely to impair bone marrow function * No history of having had treatment likely to have impaired bone marrow function * Normal blood count * Archived samples from patients with known blood disorder PATIENT CHARACTERISTICS: * See Disease Characteristics PRIOR CONCURRENT THERAPY: * See Disease Characteristics

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Oxford University Hospitals NHS Trust: lead

Study Sites (1)

Oxford Radcliffe Hospital

Oxford, England, 0X3 9DU, United Kingdom

RECRUITING

MeSH Terms

Conditions

Leukemia; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute

Interventions

DNA Methylation; Cytogenetic Analysis; Gene Expression Profiling; Polymerase Chain Reaction

Condition Hierarchy (Ancestors)

Neoplasms by Histologic Type; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases; Bone Marrow Diseases; Leukemia, Myeloid

Intervention Hierarchy (Ancestors)

Methylation; Alkylation; Biochemical Phenomena; Chemical Phenomena; Metabolism; Genetic Phenomena; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Genetic Techniques; Nucleic Acid Amplification Techniques

Study Officials

• Vyas Paresh, MD

  Oxford University Hospitals NHS Trust

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 9, 2009
• First Posted: May 12, 2009
• Study Start: January 1, 2007
• Primary Completion: December 1, 2011
• Last Updated: July 8, 2009

Record last verified: 2009-07

Locations

GB (1)