Study of Stored Tumor Samples in Young Patients With Brain Tumors

NCT00897286 | Terminated

• 1 other identifier: NBTP01
• Study Type: observational
• Target: 139
• Locations: 1 country
• Sites: 1

Brief Summary

This laboratory study is looking at stored tumor samples in young patients with brain tumors. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

Conditions

Brain and Central Nervous System Tumors

Keywords

childhood atypical teratoid/rhabdoid tumor; childhood choroid plexus tumor; childhood medulloblastoma; recurrent childhood medulloblastoma; childhood infratentorial ependymoma; childhood supratentorial ependymoma; recurrent childhood ependymoma; recurrent childhood supratentorial primitive neuroectodermal tumor; untreated childhood supratentorial primitive neuroectodermal tumor; gliomas

Outcome Measures

Primary Outcomes (1)

• Relationship between molecular abnormalities and tumor histologic and clinical characteristics

  20 Years

Study Arms (1)

Tumor/Tissue Sample

Tumor material collected prospectively from a clinically well characterized patient cohort

Eligibility Criteria

• Age: Up to 39 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Participants will all brain tumor types will be included with a focus on medulloblastoma, HGNET, CNS embryonal tumors, gliomas, ependymoma, CPC and ATRT tumors. All studies will be conducted using tumor material collected prospectively from a clinically well characterized patient cohort.

You may qualify if:

• Tumor may be primary, progressive or recurrent CNS tumor including brain and/or spine. All tumor types will be included with a focus on medulloblastoma, HGNET, CNS embryonal tumors, gliomas, ependymoma, CPC and ATRT tumors. Low grade gliomas are currently very challenging to culture and implant but if techniques mature these will also be included. Although rare, patients with ATRT may present with a primary renal and CNS tumor. In these instances samples will be collected from both the kidney and CNS tumor for analysis if available.
• Tumor may be collected at surgery prior to histologic confirmation
• Age less than 40 years at the time of initial diagnosis.
• Enrollment in the current version of the institution's banking protocol

You may not qualify if:

• Diagnosis of tumor outside the central nervous system.
• Age greater than or equal to 40 years at the time of diagnosis

Sponsors & Collaborators

• St. Jude Children's Research Hospital: lead

Study Sites (1)

St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States

Location

Related Links

• St. Jude Children's Research Hospital
• Clinical Trials Open at St. Jude

Biospecimen

Retention: SAMPLES WITH DNA

Fresh frozen, fresh and/or cryopreserved, fixed and cultured tumor cells collected prospectively from a clinically well characterized patient cohort.

MeSH Terms

Conditions

Central Nervous System Neoplasms; Rhabdoid Tumor; Choroid Plexus Neoplasms; Medulloblastoma; Familial ependymoma; Glioma

Condition Hierarchy (Ancestors)

Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Nervous System Diseases; Neoplasms, Complex and Mixed; Neoplasms by Histologic Type; Cerebral Ventricle Neoplasms; Brain Neoplasms; Brain Diseases; Central Nervous System Diseases; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neuroectodermal Tumors, Primitive; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue

Study Officials

• Amar Gajjar, MD

  St. Jude Children's Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 9, 2009
• First Posted: May 12, 2009
• Study Start: November 30, 2004
• Primary Completion: September 25, 2025
• Study Completion: September 25, 2025
• Last Updated: October 20, 2025

Record last verified: 2025-10

Locations

US (1)