Brachial Artery Peak Velocity Variation to Predict Fluid Responsiveness

NCT00890071 | Completed

• 1 other identifier: UIE-SCCU-200902
• Study Type: observational
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators designed this study to determine the predictive value for predicting fluid responsiveness of noninvasive evaluation of respiratory variation of peak velocity in brachial artery, in mechanically ventilated patients with acute circulatory failure.

Conditions

Hypotension; Shock

Keywords

Fluid responsiveness; Ultrasound; Cardiac output

Outcome Measures

Primary Outcomes (1)

• Predictive value of respiratory variation in brachial artery peak velocity before volume expansion assessed by ROC curve. We defined responser as patients that increased stroke volume index equal or more than 15% after fluid administration.

  immediately after volume expansion

Secondary Outcomes (2)

• Evaluate the predictive value of pulse pressure variation for predicting hemodynamic response to fluid administration, comparing with the predictive value of respiratory variation of brachial artery peak velocity.

  immediately after fluid administration

• Evaluate the predictive value of stroke volume variation for predicting hemodynamic response to fluid administration, comparing with the predictive value of respiratory variation of brachial artery peak velocity.

  immediately after volume expansion

Study Arms (1)

Acute circulatory failure

Patients for whom the decision to give fluids was taken because the presence of one or more clinical signs of acute circulatory failure.

Other: Fluid administration

Interventions

Fluid administration OTHER

500 ml of synthetic colloid (Voluven®, hydroxyethylstarch 6%; Fresenius, Bad Homburg, Germany) infused over 30 minutes

Acute circulatory failure

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Critical ill patients with controlled mechanical ventilation and acute circulatory failure.

You may qualify if:

• Patients with controlled mechanical ventilation, equipped with an indwelling radial artery catheter and for whom the decision to give fluids will be taken because the presence of one or more clinical signs of acute circulatory failure:
• systolic blood pressure \<90 mmHg (or a decrease \>50 mmHg in previously hypertensive patients)
• the need of vasopressor drugs
• oliguria (urine output \<0.5 ml/kg/min for at least 2 h)
• tachycardia
• delayed capillary refilling
• the presence of skin mottling

You may not qualify if:

• Contraindication for the volume administration: evidence of fluid overload and/or of hydrostatic pulmonary edema
• Patients with instable cardiac rhythm

Sponsors & Collaborators

• Hospital del SAS de Jerez: lead

Study Sites (1)

Hospital del SAS de Jerez

Jerez de la Frontera, Cádiz, 11407, Spain

Location

Related Publications (1)

• Monge Garcia MI, Gil Cano A, Diaz Monrove JC. Brachial artery peak velocity variation to predict fluid responsiveness in mechanically ventilated patients. Crit Care. 2009;13(5):R142. doi: 10.1186/cc8027. Epub 2009 Sep 3.

  PMID: 19728876 DERIVED

MeSH Terms

Conditions

Hypotension; Shock

Interventions

Hypodermoclysis

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Infusions, Subcutaneous; Infusions, Parenteral; Drug Administration Routes; Drug Therapy; Therapeutics; Fluid Therapy

Study Officials

• M. Ignacio Monge García

  Hospital del SAS de Jerez

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 28, 2009
• First Posted: April 29, 2009
• Study Start: December 1, 2008
• Primary Completion: March 1, 2009
• Study Completion: April 1, 2009
• Last Updated: April 29, 2009

Record last verified: 2009-04

Locations

ES (1)