The Effect of Bariatric Surgery on Thyroid Function and Morphology

NCT00871130 | Completed

• 1 other identifier: KEK_13_01_09
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The aim is to evaluate the effect of dramatic weight loss after bariatric surgery on thyroid function (thyroid hormone levels and particulary morphological changes) in the short and long-term setting of a cross-sectional study. A particular focus will be made with regard to putting into correlation preoperative thyroid function abnormalities and postoperative changes over time with respect to the type of bariatric intervention carried out.

Conditions

Thyroid Function; Obesity

Keywords

Thyroid gland; bariatric surgery; weight loss; thyroid hormones; adult; morbid obesity; cohort

Outcome Measures

Primary Outcomes (1)

• thyroid hormone levels (change in)

  preoperative, 3, 6 and 12 months postoperative

Secondary Outcomes (1)

• morphological changes of the thyroid gland

  up to 12 months postoperatively

Interventions

Bariatric surgery PROCEDURE

gastric banding, gastric bypass or vertical gastroplasty either open or laparoscopic or a combination of any

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients who have received a surgical procedure to result in desired weight reduction (gastric banding, gastric bypass or vertical gastroplasty either open or laparoscopic or a combination of any)

You may qualify if:

• Patients who underwent bariatric surgery between 1998 and 2007

You may not qualify if:

• age \>18 years

Sponsors & Collaborators

• Insel Gruppe AG, University Hospital Bern: lead

Study Sites (1)

Dep.of Visceral and Transplant Surgery, Bern University Hospital

Bern, 3010, Switzerland

Location

Related Publications (3)

• Chikunguwo S, Brethauer S, Nirujogi V, Pitt T, Udomsawaengsup S, Chand B, Schauer P. Influence of obesity and surgical weight loss on thyroid hormone levels. Surg Obes Relat Dis. 2007 Nov-Dec;3(6):631-5; discussion 635-6. doi: 10.1016/j.soard.2007.07.011.

  PMID: 18023816 BACKGROUND

• Alagna S, Cossu ML, Masala A, Atzeni MM, Ruggiu M, Satta FM, Fais E, Rovasio PP, Noya G. Evaluation of serum leptin levels and thyroid function in morbidly obese patients treated with bariatric surgery. Eat Weight Disord. 2003 Jun;8(2):95-9. doi: 10.1007/BF03324997.

  PMID: 12880185 BACKGROUND

• Reinehr T, Andler W. Thyroid hormones before and after weight loss in obesity. Arch Dis Child. 2002 Oct;87(4):320-3. doi: 10.1136/adc.87.4.320.

  PMID: 12244007 BACKGROUND

MeSH Terms

Conditions

Obesity; Thyroid Diseases; Weight Loss; Obesity, Morbid

Interventions

Bariatric Surgery

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Endocrine System Diseases; Body Weight Changes

Intervention Hierarchy (Ancestors)

Bariatrics; Obesity Management; Therapeutics; Surgical Procedures, Operative

Study Officials

• Vanessa Banz, MD

  Dep.of Visceral and Transplant Surgery, Bern University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: March 24, 2009
• First Posted: March 30, 2009
• Study Start: January 1, 1998
• Primary Completion: December 1, 2007
• Study Completion: December 1, 2007
• Last Updated: March 30, 2009

Record last verified: 2009-03

Locations

CH (1)