NCT00858260

Brief Summary

Searching for high morbi-mortality risk Klotho variants in dialysis patients

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,200

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2008

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2008

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2009

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

March 6, 2009

Completed
3 days until next milestone

First Posted

Study publicly available on registry

March 9, 2009

Completed
Last Updated

September 4, 2009

Status Verified

September 1, 2009

First QC Date

March 6, 2009

Last Update Submit

September 3, 2009

Conditions

Dialysis

Keywords

KlothocalciumphosphateparathormonesurvivaldialysisAdult patients undergoing maintenance dialysis since at leat three months

Outcome Measures

Primary Outcomes (1)

  • Assessing morbi-mortality based on Klotho variants

Secondary Outcomes (1)

  • Survival and serum phosphocalcic parameters

Study Arms (1)

hemodialysis patients

Adult patients undergoing maintenance dialysis since at leat three months

Genetic: blood sample

Interventions

blood sampleGENETIC

Searching for Klotho variants in DNA

hemodialysis patients

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adult patients undergoing maintenance dialysis since at leat three months

You may qualify if:

  • Every adult \> 18 years old and treated by dialysis in centers located in the Rhone Alpes area in France.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hôpital Edouard Herriot

Lyon, France

Location

Related Publications (1)

  • Marcais C, Maucort-Boulch D, Drai J, Dantony E, Carlier MC, Blond E, Genet L, Kuentz F, Lataillade D, Legrand E, Moreau-Gaudry X, Jean G, Fouque D; ARNOGENE Project. Circulating Klotho Associates With Cardiovascular Morbidity and Mortality During Hemodialysis. J Clin Endocrinol Metab. 2017 Sep 1;102(9):3154-3161. doi: 10.1210/jc.2017-00104.

    PMID: 28402487DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Searching for high morbi-mortality risk Klotho variants

MeSH Terms

Interventions

Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Specimen HandlingClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisPuncturesSurgical Procedures, OperativeInvestigative Techniques

Study Officials

  • FOUQUE Denis, MD

    Hospices Civils de Lyon

    PRINCIPAL INVESTIGATOR

  • LEGRAND Eric, MD

    CH Annonay

    PRINCIPAL INVESTIGATOR

  • KAARASLAN Huseyin, MD

    CH Bourgoin Jallieu

    PRINCIPAL INVESTIGATOR

  • ABOKASEM Ayman, MD

    CH Chalon/saône

    PRINCIPAL INVESTIGATOR

  • LATAILLADE Claire Dominique, MD

    CH Sallanches

    PRINCIPAL INVESTIGATOR

  • KUENTZ François, MD

    Centre Dialyse eaux claires

    PRINCIPAL INVESTIGATOR

  • HACHACHE Toufic, MD

    CHU Grenoble - La Tronche

    PRINCIPAL INVESTIGATOR

  • LEITIENNE Philippe, MD

    Hospices Civils de Lyon

    PRINCIPAL INVESTIGATOR

  • ARKOUCHE Walid, MD

    AURAL - Lyon

    PRINCIPAL INVESTIGATOR

  • HEYANI Ahmed, MD

    CH MACON

    PRINCIPAL INVESTIGATOR

  • HANNOUN Jacques, MD

    CH Villefranche/saône

    PRINCIPAL INVESTIGATOR

  • COMBARNOUS François, MD

    Clinique du Tonkin VILLEURBANNE

    PRINCIPAL INVESTIGATOR

  • MAUREAUGANDRY Xavier, MD

    AGDUC - Montélimar

    PRINCIPAL INVESTIGATOR

  • SIRAJEDINE Mohamed, MD

    CH ROMANS/ISERE

    PRINCIPAL INVESTIGATOR

  • JEAN Ahmed, MD

    Centre du Rein - Tassin la demi lune

    PRINCIPAL INVESTIGATOR

  • DENICOLA Cora, MD

    Calydial - CH Viennes

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

March 6, 2009

First Posted

March 9, 2009

Study Start

November 1, 2008

Study Completion

February 1, 2009

Last Updated

September 4, 2009

Record last verified: 2009-09

Locations

FR(1)