Circulating SIRT6 Expression, Effect on Aging Quality
Sirt6
Circulating Expression Measurement of a Sirtuin Protein Isoform, Sirt6, as an Early Marker of Aging Quality
1 other identifier
interventional
60
1 country
2
Brief Summary
This study follows the results of the COMPALICLAMP study (NCT00951392) where the investigators showed a differential expression of sirtuins protein isoforms, Sirt6, in muscle depending on the quality of aging. The investigators seek to confirm this difference in expression level of circulating leukocytes on a larger sample.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Mar 2012
Shorter than P25 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2012
CompletedFirst Submitted
Initial submission to the registry
March 8, 2012
CompletedFirst Posted
Study publicly available on registry
March 30, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2012
CompletedMay 28, 2019
February 1, 2012
6 months
March 8, 2012
May 23, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Sirt6 expression in circulating leukocytes based on the aging quality
analysis by quantitative RT-PCR method
participants will be followed for the duration of the visit, an expected average of 1 day
Secondary Outcomes (4)
hand and forearm muscular strength measurement
participants will be followed for the duration of the visit, an expected average of 1 day
Physical examination and anthropometric measurement
participants will be followed for the duration of the visit, an expected average of 1 day
Cognitive assessment
participants will be followed for the duration of the visit, an expected average of 1 day
Physical Activity questionnaire
participants will be followed for the duration of the visit, an expected average of 1 day
Study Arms (1)
Single Arm
OTHERInterventions
It is a single cross sectional study. All outcome measures will be taken during the investigation with physical examination, questionnaire and a blood sample
Eligibility Criteria
You may qualify if:
- Volunteers from the SUVIMAX 2 aging cohort
- Men and women
- Older than 60
- Subject with a global aging quality score of 1 or 3 in the SU.VI.MAX. 2 study
- Covered by Health Insurance System
You may not qualify if:
- Subject not in compliance with the recommendation of French National Law
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Centre de recherche en nutrition humaine Rhone-Alpes
Pierre-Bénite, 69310, France
Centre de Recherche en Nutrition Humaine
Pierre-Bénite, 69310, France
Related Publications (1)
Betry C, Meugnier E, Pflieger M, Grenet G, Hercberg S, Galan P, Kesse-Guyot E, Vidal H, Laville M. High expression of CPT1b in skeletal muscle in metabolically healthy older subjects. Diabetes Metab. 2019 Apr;45(2):152-159. doi: 10.1016/j.diabet.2018.01.018. Epub 2018 Feb 12.
PMID: 29657112RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Martine LAVILLE, Pr
Centre de recherche en nutrition humaine Rhone-Alpes
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 8, 2012
First Posted
March 30, 2012
Study Start
March 1, 2012
Primary Completion
September 1, 2012
Study Completion
September 1, 2012
Last Updated
May 28, 2019
Record last verified: 2012-02