MAP-IDM: Identification of Molecular Markers of Sudden Death at the Acute Phase of Myocardial Infarction

NCT00859300 | Completed

• 1 other identifier: 2007.463
• Study Type: observational
• Target: 1,011
• Locations: 1 country
• Sites: 1

Brief Summary

We propose a comparative case-control study on the 2 following groups of patients:

• Cases: 500 patients with ventricular fibrillation at the acute phase of myocardial infarct,
• Controls: 500 patients without ventricular fibrillation at the acute phase of myocardial infarct. The primary endpoint in this study is the correlation phenotype/genotype of sudden death at the acute phase of myocardial infarct. The first phase of the study, including patients' recruitment, clinical and biological data collection, will last 82 months. The second phase will concern the genotype/phenotype analysis and the identification of polymorphisms associated with a sudden death risk after a myocardial infarction. This study will allow a better knowledge of the mechanisms of sudden death and the identification of new risk markers.

Conditions

Myocardial Infarction

Keywords

myocardial infarction; ventricular fibrillation; sudden death; polymorphism

Outcome Measures

Primary Outcomes (1)

• Correlation phenotype/genotype of sudden death at the acute phase of myocardial infarct.

  Correlation phenotype/genotype

Study Arms (2)

1

500 patients with ventricular fibrillation at the acute phase of myocardial infarct

Genetic: Blood sample

2

500 patients without ventricular fibrillation at the acute phase of myocardial infarct.

Genetic: Blood sample

Interventions

Blood sample GENETIC

Blood sample Determination of genetic background

1

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Cases: 500 patients with ventricular fibrillation at the acute phase of myocardial infarct, Controls: 500 patients without ventricular fibrillation at the acute phase of myocardial infarct.

You may qualify if:

• All patients admitted to ICU for MI and presenting the following criteria:
• Age \> 18
• Group 1 (Case) Patients with cardiac arrest and ventricular fibrillation developed up to 24 h post MI Group 2 (control) Patients with MI (no ventricular fibrillation)
• Written informed consent.

You may not qualify if:

• No written informed consent
• Known Medical History of cardiomyopathy, including acute coronary syndrome

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Hôpital cardiologique

Lyon, 69677, France

Location

Related Publications (2)

• Chevalier P, Roy P, Bessiere F, Morel E, Ankou B, Morgan G, Halder I, London B, Minobe WA, Slavov D, Deliniere A, Bochaton T, Paganelli F, Lesavre N, Boiteux C, Mansourati J, Maury P, Clerici G, Winum PF, Huebler SP, Carroll IA, Bristow MR. Impact of Neuroeffector Adrenergic Receptor Polymorphisms on Incident Ventricular Fibrillation During Acute Myocardial Ischemia. J Am Heart Assoc. 2023 Mar 21;12(6):e025368. doi: 10.1161/JAHA.122.025368. Epub 2023 Mar 16.

  PMID: 36926933 DERIVED

• Chevalier P, Moreau A, Bessiere F, Richard S, Chahine M, Millat G, Morel E, Paganelli F, Lesavre N, Placide L, Montestruc F, Ankou B, Puertas RD, Asatryan B, Deliniere A; MAP-IDM Investigators. Identification of Cx43 variants predisposing to ventricular fibrillation in the acute phase of ST-elevation myocardial infarction. Europace. 2023 Feb 8;25(1):101-111. doi: 10.1093/europace/euac128.

  PMID: 35942675 DERIVED

MeSH Terms

Conditions

Myocardial Infarction; Ventricular Fibrillation; Death, Sudden

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Arrhythmias, Cardiac; Death

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• CHEVALIER Philippe, MD

  Hospices Civils de Lyon

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 5, 2008
• First Posted: March 11, 2009
• Study Start: December 1, 2007
• Primary Completion: June 1, 2015
• Study Completion: June 1, 2015
• Last Updated: March 16, 2016

Record last verified: 2016-03

Locations

FR (1)