Parkinson's Disease Genetics Database

NCT00855556 | Terminated

• 1 other identifier: GCRC 0171
• Study Type: observational
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of the study is to develop and organize an effort to identify genes that determine an individual's risk for developing Parkinson's disease (PD).

1. 1.To ascertain, study and establish a repository of DNA samples that will allow for the identification of known and yet-to-be-identified genetic markers associated with the development of PD.
2. 2.To create a database with clinical, genetic (HLA, genome screen) and medical history information that will facilitate the search for PD susceptibility genes.
3. 3.To provide a centralized DNA repository to allow for targeted studies of genetic factors contributing to the onset, heterogeneity and progression of PD.
4. 4.To evaluate opportunities to extend the results of research to develop methods of risk prediction, prevention and therapy for PD.

Conditions

Parkinson's Disease

Outcome Measures

Primary Outcomes (1)

• the current protocol is for establishment of the registry only and not for particular analyses of its contents

  5 years

Interventions

blood draw GENETIC

The blood collection is designed to obtain blood samples as a source of DNA for genotyping and to establish a plasma and serum storage repository for future assays. GCRC nurses will perform all blood draws associated with this study. The following procedures are designed to standardize sample collection: 1. Blood will be collected with the participant in the seated position with the reclining position reserved for those with a history of fainting during blood collection. 2. Participants will be instructed to drink plenty of water (e.g., at least 8 large glasses of water) prior to the clinic visit as this facilitates easier collection. 3. No fasting, activity or medication restrictions are required prior to or following blood collection. 4. Blood collection will follow completion of the questionnaires. They will be performed by a nurse or technician with documented class time and experience in phlebotomy. Technician certification will occur prior to blood collection.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects with a diagnosis of Parkinson's Disease as determined by standard neurological criteria.

You may qualify if:

• Subjects must have a diagnosis of Parkinson's Disease as determined by standard neurological criteria.
• Patients ≥18 years of age who are able to provide informed consent
• Patients ≥ 18 who are decisionally impaired for whom informed consent can be obtained by a legally authorized representative.

You may not qualify if:

• Patients without a diagnosis of Parkinson's Disease.

Sponsors & Collaborators

• Northwell Health: lead

Study Sites (1)

The Feinstein Institute for Medical Research

Manhasset, New York, 11030, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

DNA stored in TE buffer solution

MeSH Terms

Conditions

Parkinson Disease

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Michael Pourfar, MD

  Northwell Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 25, 2009
• First Posted: March 4, 2009
• Study Start: February 1, 2008
• Primary Completion: February 1, 2013
• Study Completion: February 1, 2013
• Last Updated: September 16, 2015

Record last verified: 2015-09

Locations

US (1)