Web-based Genetic Research on Parkinson's Disease
Ongoing, Web-Based Genome-Wide Association Studies for Targeted Disease Initiatives
1 other identifier
observational
13,576
1 country
1
Brief Summary
The purpose of this study is to examine how genes and environment affect risk for Parkinson's disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2009
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2009
CompletedFirst Submitted
Initial submission to the registry
May 9, 2011
CompletedFirst Posted
Study publicly available on registry
May 11, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 23, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
June 23, 2021
CompletedNovember 3, 2022
November 1, 2022
12.2 years
May 9, 2011
November 1, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Saliva DNA test and online surveys with questions about Parkinson's disease experience, symptoms and response to treatment
We want to learn how genes and environment could play role in Parkinson's disease risk and progression
Intermittent surveys every 6 months for up to 24 months
Study Arms (1)
Parkinson's disease patients
People diagnosed with Parkinson's disease by a physician
Eligibility Criteria
Community Sample
You may qualify if:
- diagnosis of Parkinson's disease by a physician
You may not qualify if:
- diagnoses other than Parkinson's, including:
- progressive supranuclear palsy (PSP)
- multiple system atrophy (MSA)
- Shy-Drager syndrome
- spinal cerebella ataxia (SCA)
- atypical parkinsonism
- parkinsonism due to medications, drug-induced parkinsonism
- vascular parkinsonism
- frontotemporal dementia with parkinsonism
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- 23andMe, Inc.lead
- Michael J. Fox Foundation for Parkinson's Researchcollaborator
- The Parkinson's Institutecollaborator
Study Sites (1)
Www.23Andme.Com/Pd
Mountain View, California, 94043, United States
Related Publications (4)
Do CB, Tung JY, Dorfman E, Kiefer AK, Drabant EM, Francke U, Mountain JL, Goldman SM, Tanner CM, Langston JW, Wojcicki A, Eriksson N. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. PLoS Genet. 2011 Jun;7(6):e1002141. doi: 10.1371/journal.pgen.1002141. Epub 2011 Jun 23.
PMID: 21738487RESULTLill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP; 23andMe Genetic Epidemiology of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium; Parkinson's Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2); Young P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP, Bertram L. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet. 2012;8(3):e1002548. doi: 10.1371/journal.pgen.1002548. Epub 2012 Mar 15.
PMID: 22438815RESULTPichler I, Del Greco M F, Gogele M, Lill CM, Bertram L, Do CB, Eriksson N, Foroud T, Myers RH; PD GWAS Consortium; Nalls M, Keller MF; International Parkinson's Disease Genomics Consortium; Wellcome Trust Case Control Consortium 2; Benyamin B, Whitfield JB; Genetics of Iron Status Consortium; Pramstaller PP, Hicks AA, Thompson JR, Minelli C. Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study. PLoS Med. 2013;10(6):e1001462. doi: 10.1371/journal.pmed.1001462. Epub 2013 Jun 4.
PMID: 23750121RESULTNalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R; International Parkinson's Disease Genomics Consortium (IPDGC); Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI); 23andMe; GenePD; NeuroGenetics Research Consortium (NGRC); Hussman Institute of Human Genomics (HIHG); Ashkenazi Jewish Dataset Investigator; Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE); North American Brain Expression Consortium (NABEC); United Kingdom Brain Expression Consortium (UKBEC); Greek Parkinson's Disease Consortium; Alzheimer Genetic Analysis Group; Ikram MA, Ioannidis JP, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, Heutink P, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet. 2014 Sep;46(9):989-93. doi: 10.1038/ng.3043. Epub 2014 Jul 27.
PMID: 25064009RESULT
Related Links
Biospecimen
Saliva samples are collected for DNA analysis
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 9, 2011
First Posted
May 11, 2011
Study Start
April 1, 2009
Primary Completion
June 23, 2021
Study Completion
June 23, 2021
Last Updated
November 3, 2022
Record last verified: 2022-11