Molecular-Genetic Correlates of Fatigue in Cancer Patients Receiving Localized External Beam Radiation Therapy

You may not qualify if:

• All participants with any one of the following criteria will be excluded:
• Progressive or unstable disease of any body system causing clinically significant fatigue, including cardiovascular, pulmonary, gastrointestinal, central nervous system, psychiatric, endocrine, hematologic, renal, or immunologic disorders, and including patients with any of the following broad disease categories:
• Systemic infections (e.g., human immunodeficiency virus (HIV), active hepatitis);
• Documented history of major depression, bipolar disease, psychosis, or alcohol dependence/abuse within the past 5 years;
• Uncorrected hypothyroidism and anemia;
• Chronic inflammatory disease that may be anticipated to alter the proinflammatory cytokine profile (i.e. rheumatoid arthritis, systemic lupus erythematosus, and cirrhosis).
• Patients taking tranquilizers, steroids, and nonsteroidal anti-inflammatory agents because these medications are known to affect cytokine production;
• Patients who have second malignancies or those receiving chemotherapy with their EBRT.
• In addition to the above criteria, participants with the following conditions will be excluded from participating in the exercise interventions:
• Significant Restrictive or Obstructive Lung Disease
• Ischemic heart disease
• Left ventricular dysfunction
• Acute corpulmonale
• Cardiomyopathy (dilated, hypertrophic, or non-idiopathic)
• Significant renal or hepatic dysfunction
• +6 more criteria