The Effects of Chiropractic on Cancer-related Fatigue

NCT07300319 | Suspended

• 1 other identifier: I-0037
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this randomized controlled study is to investigate the impact of chiropractic care on CCRF (Chronic Cancer Related Fatigue) and other health-related challenges that burden cancer survivors.

Conditions

Fatigue; Cancer

Keywords

Cancer; Fatigue; Chiropractic Care; Delayed Start

Outcome Measures

Primary Outcomes (5)

• Number of Eligible Randomized Participants

  The proportion of eligible participants randomized into the study

  2 years

• Number of Participants Who Adhere to Study

  Proportion of enrolled participants who adhere to the pre-baseline assessment lifestyle restrictions as instructed. This assesses compliance.

  2 years

• Number of Participants That Can Fulfill Study Activities

  Proportion of participants that can fulfill the given baseline assessment as directed. This assesses tolerability

  2 years

• Number of Participants Who Chiropractic Sessions

  Proportion of randomized adults attending ≥90% of chiro sessions within 7 days of the prescribed time frame. This assesses adherence to treatment.

  2 years

• Number of Enrolled Intervention Group Participants

  Proportion of the immediate-start group attending the final assessment session. This assesses retention.

  2 years

Study Arms (2)

Delayed Group

ACTIVE COMPARATOR

After the 6-week lab assessments, the participants in the delayed group will be offered 6 weeks of chiropractic care.

Other: Delayed Chiropractic Care

Immediate Group

EXPERIMENTAL

After the baseline assessment, the participants in the intervention group will receive 12 weeks of chiropractic care.

Other: Immediate Chiropractic Care

Interventions

Immediate Chiropractic Care OTHER

Participants in the immediate start group will be assigned to chiropractic care for 12 weeks. Participants will have their upper cervical spine (C1/C2) assessed for the presence of vertebral subluxations per the chiropractor's normal and customary procedures and adjusted if necessary.

Immediate Group

Delayed Chiropractic Care OTHER

Participants in the delayed start group will be assigned to chiropractic care for 6 weeks. Participants will have their upper cervical spine (C1/C2) assessed for the presence of vertebral subluxations per the chiropractor's normal and customary procedures and adjusted if necessary.

Delayed Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years of age.
• Self-report that they have been informed by their primary health care provider that they are cancer-free (this is sometimes referred to as 'complete remission' or 'cured').
• Minimum of 3 months since the completion of their primary curative-intent cancer therapies including surgery, chemotherapy, radiotherapy, and/or immunotherapy (long-term hormone therapy permitted)
• Scores in the moderate-to-severe range (i.e., at or above the 60th percentile) on the FACIT-Fatigue scale.
• Fatigue onset was at some point during their illness/treatment \& negatively impacts their quality of life \& daily functioning.

You may not qualify if:

• Chiropractic care within the past 2 weeks
• Taking short-acting benzodiazepines which include midazolam/Versed \& triazolam/Halcion.
• Taking GLP-1 medications
• Taking other types of prescription medications (including hormone therapy) and hasn't been on a stable dose for a minimum of 6 weeks with plans to change medications or doses during the study.
• Disorders that cause fainting during rapid postural changes (e.g., POTS, orthostatic hypotension).
• Not able to make a fist or grip objects with one or both hands
• Deaf in one or both ears (hearing aids are ok)
• Heart conditions, including pacemakers, which impact heart function
• Diagnosed with rheumatoid arthritis, osteoporosis, or medically diagnosed cervical spine instability.
• Current litigation related to a physical, health-related injury.
• Pregnant

Sponsors & Collaborators

• Life University: lead

Study Sites (1)

Center for Chiropractic Research

Marietta, Georgia, 30060, United States

Location

MeSH Terms

Conditions

Neoplasms; Fatigue

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Tyson Perez, DC, PhD

  Life University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 10, 2025
• First Posted: December 23, 2025
• Study Start (Estimated): February 1, 2027
• Primary Completion (Estimated): February 1, 2028
• Study Completion (Estimated): February 1, 2028
• Last Updated: March 30, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)