NCT00838448

Brief Summary

In this study the investigators will explore the relationship between physical activity and cannabis use. The investigators will compare regional brain activation detected by imaging technique(fRMI) before and after exercise in cannabis users and compare results with results from controls. The investigators hypothesize that the regional brain activation in response to visual cues (pictures related to cannabis use and food) will be different in cannabis users than in controls and that exercise will significantly alter brain responses to the cues.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2009

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2009

Completed
22 days until next milestone

First Submitted

Initial submission to the registry

January 23, 2009

Completed
14 days until next milestone

First Posted

Study publicly available on registry

February 6, 2009

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2011

Completed
2.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2013

Completed
Last Updated

June 12, 2013

Status Verified

June 1, 2013

Enrollment Period

2 years

First QC Date

January 23, 2009

Last Update Submit

June 11, 2013

Conditions

Cannabis Dependence

Keywords

exercisecannabis usevisual cues

Outcome Measures

Primary Outcomes (1)

  • Craving for cannabis

    1 hour

Study Arms (2)

Cannabis users

EXPERIMENTAL

Cannabis users

Behavioral: Exercise

Cannabis no-users

EXPERIMENTAL

Cannabis no-users

Behavioral: Exercise

Interventions

ExerciseBEHAVIORAL

Exercise performed on a treadmill for 20-30 minutes

Cannabis no-usersCannabis users

Eligibility Criteria

Age18 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Cases and Controls must:
  • Be able to understand the study and provide written informed consent.
  • Be male or female 18 -35 years of age.
  • Be in generally good health
  • If female of childbearing potential, have a negative serum pregnancy test on study day
  • Cases must:
  • Meet criteria for cannabis dependence as primary diagnosis as determined by the Substance Abuse module of SCID (Structured Clinical Interview for DSM-IV).
  • Not currently seeking treatment for cannabis dependence.
  • Have a positive urine drug test for cannabis on the study day
  • Avoid alcohol and other recreational drug use (except cannabis and/or nicotine) for 48 h before testing.

You may not qualify if:

  • Cases and Controls must not:
  • Be pregnant or lactating
  • Have implanted electrical medical device (e.g. pacemaker, vagal nerve stimulator)
  • Have non-secure metallic foreign bodies
  • Have met criteria for another axis 1 diagnosis in the past 6 months
  • Receive psychotropically active or vasoactive medications (within 6 weeks of screen day)
  • Have chronic medical illness
  • Have epilepsy
  • Have a history of head injury that required hospitalization
  • Have claustrophobia
  • Have orthopedic or other problems precluding them from performing exercise protocol
  • Have body mass index (BMI) less than 19 kg/m2
  • Weighing more than 275 pounds (MRI table limit)
  • Cases must not:
  • Have current dependence, as determined by the SCID, on any psychoactive substance other than nicotine and/or cannabinoid
  • +1 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

Location

Related Publications (2)

  • Charboneau EJ, Dietrich MS, Park S, Cao A, Watkins TJ, Blackford JU, Benningfield MM, Martin PR, Buchowski MS, Cowan RL. Cannabis cue-induced brain activation correlates with drug craving in limbic and visual salience regions: preliminary results. Psychiatry Res. 2013 Nov 30;214(2):122-31. doi: 10.1016/j.pscychresns.2013.06.005. Epub 2013 Sep 12.

    PMID: 24035535DERIVED

  • Buchowski MS, Meade NN, Charboneau E, Park S, Dietrich MS, Cowan RL, Martin PR. Aerobic exercise training reduces cannabis craving and use in non-treatment seeking cannabis-dependent adults. PLoS One. 2011 Mar 8;6(3):e17465. doi: 10.1371/journal.pone.0017465.

    PMID: 21408154DERIVED

MeSH Terms

Conditions

Marijuana AbuseMotor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Substance-Related DisordersChemically-Induced DisordersMental DisordersBehavior

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Maciej S Buchowski, Ph.D.

    Vanderbilt University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Research Professor

Study Record Dates

First Submitted

January 23, 2009

First Posted

February 6, 2009

Study Start

January 1, 2009

Primary Completion

January 1, 2011

Study Completion

June 1, 2013

Last Updated

June 12, 2013

Record last verified: 2013-06

Locations

US(1)